Patents by Inventor Yosuke TERAO

Yosuke TERAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11542301
    Abstract: The present application addresses the problem of providing an Fc-binding protein having an improved antibody separation ability. The present application also addresses the problem of providing a high-accuracy antibody separation method using an insoluble carrier having the protein immobilized thereon. The problems can be solved by: an Fc-binding protein in which at least an amino acid substitution at a specific position therein occurs and which has reduced affinity for an antibody; and an antibody separation method including allowing an equilibration buffer solution to pass through a column in which an insoluble carrier having the protein immobilized thereon is filled to equilibrate the column, adding a solution containing an antibody to cause the adsorption of the antibody onto the carrier, and eluting the antibody adsorbed on the carrier using an elution solution.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: January 3, 2023
    Assignee: TOSOH CORPORATION
    Inventors: Yosuke Terao, Yoshiharu Asaoka, Ryoko Otake, Satoshi Endo, Naoki Yamanaka, Yukie Yamamoto, Seigo Oe
  • Publication number: 20220290749
    Abstract: A vehicle drive device is provided that can suppress the increase in dimension in the radial direction while ensuring a sufficient speed reduction ratio. Two driving force sources are arranged on a first axis, two output members are arranged on a second axis, two counter gear mechanisms are arranged on a third axis. A planetary gear mechanism is configured to transmit rotation from the two counter gear mechanisms to the output members, and is disposed so as to overlap with both of the two counter gear mechanisms as seen in an axial direction along and axial direction.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 15, 2022
    Applicants: AISIN CORPORATION, MITSUBISHI JIDOSHA KOGYO KABUSHIKI KAISHA
    Inventors: Toshihisa MIZUTANI, Kenta KATAOKA, Taiki OWARI, Hiroaki OSANAI, Daiki SUYAMA, Hiroshi KATO, Yuki YANAGIHARA, Naoki TAKAHASHI, Kiminobu TERAO, Takuya OGASAWARA, Yosuke MORIMOTO
  • Patent number: 11427828
    Abstract: The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn ? chain and/or a ?2 microglobulin region of a human FcRn ? chain by another specific amino acid.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 30, 2022
    Assignee: TOSOH CORPORATION
    Inventors: Yosuke Terao, Naoki Yamanaka, Natsuko Kizu, Satoshi Endo, Seigo Oe
  • Patent number: 11414475
    Abstract: The problem to be addressed by the present invention is to provide improved recombinant Fc?RIIb and Fc?RIIa that do not require refolding and exhibit high productivity and thermal stability, and to provide a method for producing the same. Said problem is solved by improved recombinant Fc?RIIb comprising at least the amino acid residues of the extracellular domain of human Fc?RIIb (No. 43 to No. 215 in UniProt No. P31994), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 82, 94, 98, 104, 105, or 139 in UniProt No. P31994. Said problem is also solved by improved recombinant Fc?RIIa comprising at least the amino acid residues of the extracellular domain of human Fc?RIIa (No. 34 to No. 206 in UniProt No. P12318-1), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 73, 85, 89, 95, 96, or 130 in UniProt No. P12318-1.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: August 16, 2022
    Assignees: TOSOH CORPORATION, SAGAMI CHEMICAL RESEARCH INSTITUTE
    Inventors: Kouta Hatayama, Teruhiko Ide, Hiroyuki Ito, Yosuke Terao, Naoki Yamanaka, Satoshi Endo
  • Publication number: 20210277053
    Abstract: The invention aims to provide an immunoglobulin-binding protein having improved chemical stability, especially stability against alkali. The object can be achieved by improving stability against alkali by substituting an amino acid residue(s) at a particular position(s) in an immunoglobulin-binding domain such as domain C of protein A derived from a bacterium belonging to the genus Staphylococcus, to another/other particular amino acid residue(s).
    Type: Application
    Filed: November 8, 2018
    Publication date: September 9, 2021
    Applicant: TOSOH CORPORATION
    Inventors: Naoki YAMANAKA, Yukie UCHIDA, Yosuke TERAO
  • Publication number: 20210261605
    Abstract: The present invention relates to an Fc-binding protein exhibiting improved alkaline resistance, a method for producing said protein, an antibody adsorbent obtained by immobilizing said protein on a carrier, and a method for separating an antibody using said adsorbent.
    Type: Application
    Filed: October 26, 2018
    Publication date: August 26, 2021
    Applicant: TOSOH CORPORATION
    Inventors: Ryoko WATANABE, Satoshi ENDO, Yosuke TERAO, Seigo OE
  • Publication number: 20210116445
    Abstract: An object of the present invention is to provide a method for detecting the presence or absence of a disease, the risk of developing a disease, the degree of progression of a disease and/or the degree of progression of aging, in a subject. The present invention achieves the above described object by a method including the following steps (a) to (c): (a) adding a solution containing an antibody obtained from a subject to a column filled with an insoluble carrier on which an Fc-binding protein is immobilized, to allow the antibody to be adsorbed on the carrier; (b) eluting the antibody adsorbed on the carrier using an eluent, to obtain data of a separation pattern of the antibody; and (c) detecting the presence or absence of a disease, the risk of developing a disease, the degree of progression of a disease and/or the degree of progression of aging, in the subject, using the data as an indicator.
    Type: Application
    Filed: June 18, 2019
    Publication date: April 22, 2021
    Applicant: TOSOH CORPORATION
    Inventors: Yosuke TERAO, Yasuyuki AKIYAMA, Satoshi ENDO, Ryoko WATANABE
  • Publication number: 20210002367
    Abstract: An Fc-binding protein having at least amino acid residues of the extracellular domain of the amino acid sequence of wildtype human Fc?RIIa (UniProt Accession Number: P12318) wherein the amino acid residues in the domain have an amino acid substitution or deletion at at least a specific position, a method for producing the protein, and an antibody adsorbent using the protein.
    Type: Application
    Filed: February 21, 2019
    Publication date: January 7, 2021
    Applicant: TOSOH CORPORATION
    Inventors: Masumi TAKAYAMA, Yosuke TERAO
  • Patent number: 10815289
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: October 27, 2020
    Assignee: TOSOH CORPORATION
    Inventors: Yoshiharu Asaoka, Toru Tanaka, Yosuke Terao, Naoki Yamanaka, Natsuko Kizu, Masaru Aoki, Teruhiko Ide
  • Publication number: 20200283779
    Abstract: The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn ? chain and/or a ?2 microglobulin region of a human FcRn ? chain by another specific amino acid.
    Type: Application
    Filed: April 13, 2018
    Publication date: September 10, 2020
    Applicant: TOSOH CORPORATION
    Inventors: Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Satoshi ENDO, Seigo OE
  • Publication number: 20200223885
    Abstract: The present application addresses the problem of providing an Fc-binding protein having an improved antibody separation ability. The present application also addresses the problem of providing a high-accuracy antibody separation method using an insoluble carrier having the protein immobilized thereon. The problems can be solved by: an Fc-binding protein in which at least an amino acid substitution at a specific position therein occurs and which has reduced affinity for an antibody; and an antibody separation method including allowing an equilibration buffer solution to pass through a column in which an insoluble carrier having the protein immobilized thereon is filled to equilibrate the column, adding a solution containing an antibody to cause the adsorption of the antibody onto the carrier, and eluting the antibody adsorbed on the carrier using an elution solution.
    Type: Application
    Filed: February 7, 2018
    Publication date: July 16, 2020
    Applicant: TOSOH CORPORATION
    Inventors: Yosuke TERAO, Yoshiharu ASAOKA, Ryoko OTAKE, Satoshi ENDO, Naoki YAMANAKA, Yukie YAMAMOTO, Seigo OE
  • Publication number: 20190233499
    Abstract: The problem to be addressed by the present invention is to provide improved recombinant Fc?RIIb and Fc?RIIa that do not require refolding and exhibit high productivity and thermal stability, and to provide a method for producing the same. Said problem is solved by improved recombinant Fc?RIIb comprising at least the amino acid residues of the extracellular domain of human Fc?RIIb (No. 43 to No. 215 in UniProt No. P31994), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 82, 94, 98, 104, 105, or 139 in UniProt No. P31994. Said problem is also solved by improved recombinant Fc?RIIa comprising at least the amino acid residues of the extracellular domain of human Fc?RIIa (No. 34 to No. 206 in UniProt No. P12318-1), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 73, 85, 89, 95, 96, or 130 in UniProt No. P12318-1.
    Type: Application
    Filed: September 21, 2017
    Publication date: August 1, 2019
    Applicants: TOSOH CORPORATION, SAGAMI CHEMICAL RESEARCH INSTITUTE
    Inventors: Kouta HATAYAMA, Teruhiko IDE, Hiroyuki ITO, Yosuke TERAO, Naoki YAMANAKA, Satoshi ENDO
  • Publication number: 20190211077
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Application
    Filed: June 24, 2015
    Publication date: July 11, 2019
    Applicant: TOSOH CORPORATION
    Inventors: Yoshiharu ASAOKA, Toru TANAKA, Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Masaru AOKI, Teruhiko IDE
  • Publication number: 20170218044
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Application
    Filed: June 24, 2015
    Publication date: August 3, 2017
    Applicant: TOSOH CORPORATION
    Inventors: Yoshiharu ASAOKA, Toru TANAKA, Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Masaru AOKI, Teruhiko IDE