Patents by Inventor Yotam DRIER

Yotam DRIER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of detecting insulator dysfunction and oncogene activation for screening, diagnosis and treatment of patients in need thereof
    Patent number: 11339442
    Abstract: The present application generally to the diagnosis and treatment of diseases resulting from the alteration of chromatin boundaries between topologically-associated domains. In particular, the present application relates to detection of mutations causing DNA hypermethylation phenotypes, CpG methylation within CTCF binding motifs, and aberrant gene expression caused by altered chromatin topology. Applicants show that IDH mutant gliomas exhibit hyper-methylation at CTCF binding sites, compromising binding of this methylation-sensitive insulator protein. Applicants also demonstrate that loss of CTCF at a domain boundary permits a constitutive enhancer to aberrantly interact with the receptor tyrosine kinase gene PDGFRA, a prominent glioma oncogene. Thus, Applicants have uncovered that IDH mutations may promote gliomagenesis by disrupting chromosomal topology and allowing aberrant regulatory interactions that induce oncogene expression.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: May 24, 2022
    Assignee: The General Hospital Corporation
    Inventors: Bradley Bernstein, Yotam Drier, William Flavahan, Daniel Tarjan
  • METHODS OF DETECTING INSULATOR DYSFUNCTION AND ONCOGENE ACTIVATION FOR SCREENING, DIAGNOSIS AND TREATMENT OF PATIENTS IN NEED THEREOF
    Publication number: 20200224274
    Abstract: The present application generally to the diagnosis and treatment of diseases resulting from the alteration of chromatin boundaries between topologically-associated domains. In particular, the present application relates to detection of mutations causing DNA hypermethylation phenotypes, CpG methylation within CTCF binding motifs, and aberrant gene expression caused by altered chromatin topology. Applicants show that IDH mutant gliomas exhibit hyper-methylation at CTCF binding sites, compromising binding of this methylation-sensitive insulator protein. Applicants also demonstrate that loss of CTCF at a domain boundary permits a constitutive enhancer to aberrantly interact with the receptor tyrosine kinase gene PDGFRA, a prominent glioma oncogene. Thus, Applicants have uncovered that IDH mutations may promote gliomagenesis by disrupting chromosomal topology and allowing aberrant regulatory interactions that induce oncogene expression.
    Type: Application
    Filed: December 14, 2016
    Publication date: July 16, 2020
    Inventors: Bradley Bernstein, Yotam Drier, William Flavahan, Daniel Tarjan
  • Method and System for Non-linear Quantification of Pathway Deregulation for Analysis of Malignancies
    Publication number: 20140229116
    Abstract: A system and method for non-linear quantification of pathway deregulation in an individual biological sample for analysis of malignancies.
    Type: Application
    Filed: February 14, 2014
    Publication date: August 14, 2014
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Eytan DOMANY, Michal SHEFFER, Shlomo URBACH, Yotam DRIER