Abstract: Provided is a lithium secondary battery including a positive electrode, a negative electrode, a separator, and a non-aqueous electrolyte, wherein the positive electrode includes a positive electrode active material comprising lithium iron phosphate particles, and the positive electrode has a loading amount of 450 mg/25 cm2 to 740 mg/25 cm2, and the non-aqueous electrolyte includes a lithium salt, an organic solvent, and an additive, wherein the organic solvent includes ethylene carbonate, and dimethyl carbonate, and the dimethyl carbonate is included in 5 vol % to 75 vol % in the organic solvent, and the additive contains vinylene carbonate, and the weight ratio of the vinylene carbonate to the dimethyl carbonate is greater than 0 to 0.2 or less.

Abstract: An electrolyte additive comprising a compound represented by Formula 1 below forms a coating film on an electrode surface in the activation of a secondary battery, thereby the generation of a large amount of gas under a high temperature condition can be prevented, and a cell OCV drop and a decrease in capacity retention rate, which are caused by elution of metal ions from an electrode, can be effectively prevented, resulting in effective improvement in durability, performance and high-temperature safety of the battery, wherein R1, R2, and M are described herein.

Abstract: Proposed are an adenine base editor having increased thymine-cytosine sequence-specific cytosine base editing activity, a cytosine base editing method, and a cytosine base editing kit. The editor, produced by introducing a P48R mutation into an adenosine deaminase, has an operating range that is more sophisticated than conventional cytosine base editors, allows cytosine base editing only when cytosine is positioned right behind thymine, thereby enabling elaborate editing even when there is a plurality of cytosines within the range, and enables cytosine to be substituted with thymine or guanine in the presence or absence of UGI, respectively. Therefore, the cytosine base editing composition can be effectively used in the fields of gene therapy or new crop development which requires precise editing of only cytosine in all living organisms, including humans, plants, and bacteria.

Abstract: The present invention relates to an adenine base editor from which cytosine editing activity is removed, a method of editing an adenine base, and method of editing an adenine base. In the present invention, it was confirmed that four mutations (V106W, D108Q, F148A and F149A) in adenosine deaminase increase the specificity for adenine editing by reducing cytosine base editing efficiency, and ABE variants were manufactured by introducing respective mutations into a variety of more improved adenine base editors than ABEmax, and tested, confirming that the mutations significantly decrease a cytosine editing effect. Therefore, the adenine base editor according to the present invention is able to more accurately edit adenine, and the method of editing an adenine base can be effectively used in the field of gene therapy that has to accurately edit only adenine in all living organisms including humans, plants and bacteria or novel crop development.

Abstract: The present invention relates to an electrolyte composition including a lithium salt; a non-aqueous organic solvent; a compound represented by a specific formula; and a perfluoropolyether oligomer, a gel polymer electrolyte including a polymer network which is formed by a polymerization reaction of the electrolyte composition, and a lithium secondary battery including the same.

Abstract: The present technology relates to a lithium secondary battery. The lithium secondary battery has advantages of excellent high-rate discharge characteristics at room temperature as well as excellent discharge efficiency at low temperature when a coating layer containing specific contents of a lithium element, a sulfur element, and a nitrogen element is provided on a positive electrode mixture layer including a positive electrode active material.

Abstract: A lithium secondary battery includes Li6CoO4 containing excess lithium, or the like as an irreversible additive in a positive electrode, and at the same time, includes an electrolyte additive of Formula 1 having a specific molecular weight in an electrolyte to realize low battery resistance and effectively prevent metal ions from being exsolved from the irreversible additive, and thus has advantages of excellent battery performance and lifespan, wherein R1 to R5, p, q, r, m and n are described herein.

Abstract: A lithium secondary battery has excellent economic feasibility and safety because an iron phosphate of Formula 2 having an olivine structure is included as a positive electrode active material, and also has advantages of excellent battery performance and lifespan because an electrolyte additive of Formula 1 having a specific molecular weight is included in an electrolyte to improve an increase in internal resistance of the battery during charging and discharging and effectively prevent iron ions from being exsolved from the positive electrode active material, wherein R1to R5, p, q, r, m and n are described herein.

Abstract: An electrolyte composition and a lithium secondary battery including the same are disclose herein. The electrolyte composition has improved high temperature safety. In some embodiments, the electrolyte composition includes an additive including a compound represented by Formula 1. Each R1 is independently a single bond, an alkylene group having 1 to 10 carbon atoms, or each R2 is independently a double or triple bond including 2 carbon atoms, each R3 is independently hydrogen or an alkyl group having 1 to 4 carbon atoms, and a is an integer of 1 to 10. The additive may reinforce an SEI layer on the surface of an electrode, thereby having advantages of improved storage and lifetime characteristics at a high temperature and a decreased amount of gas generated in the battery.

Abstract: An additive for a non-aqueous electrolyte, a non-aqueous electrolyte including the same, and a lithium secondary battery including the same are disclosed herein. The additive includes an ionic compound to form a coating film on an electrode surface, thereby preventing gas generation at high temperature, a cell open-circuit voltage (OCV) drop, and a decrease in capacity retention rate, which are caused by elution of metal ions from an electrode. The additive improves durability, performance, and high temperature safety of the battery.

Abstract: The present invention relates to a cytosine base-editing composition, and more specifically, to a cytosine base-editing composition comprising adenine deaminase and CRISPR-associated protein 9 (Cas9), or functional analogs thereof, which has a narrow editing window and thus is capable of accurately editing cytosine in a target sequence with another base. The present inventors have discovered that the application of the cytosine base-editing composition comprising adenine deaminase and Cas9, or functional analogs thereof, to a target sequence, causes cytosine on a specific motif to be substituted with another base, and that existing adenine base editors (ABEs) are capable of editing not only adenine but also cytosine, and can also have said substitutions occur with higher accuracy compared to existing cytosine base editors (CBEs).