Abstract: The present application relates to a system and a method for effectively screening and assessing agents for tumor immunotherapy, which includes assessment for the effects of target cells, non-target cells, and tumor infiltration. The system and method of the present application can be used to comprehensively and systematically assess the effectiveness and safety of the agent against tumor immune cells.

Abstract: The present disclosure provides an application of non-phosphorylated ?-catenin protein in tumor cells as a biomarker for predicting the responsivity or sensitivity of tumor cells to wnt pathway inhibitors, a method of using non-phosphorylated ?-catenin protein in tumor cells as a biomarker to predict the responsivity or sensitivity of tumor cells to wnt pathway inhibitors, a method for treating tumor patients, a method for detecting the content of non-phosphorylated ?-catenin in tumor tissues or tumor cells, and a suitable wnt inhibitor.

Abstract: A compound of formula (I) having the activity of inhibiting HPK1 kinase and a pharmaceutical composition comprising the compound. Also provided are the use of the compound in the prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases or immune-mediated diseases.

Abstract: Provided are a compound having the structure of formula (I) for inhibiting Wnt pathway activity, a pharmaceutical composition comprising the compound, and use of the compound in prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases, or immune-mediated diseases.

Abstract: The present application relates to a system and a method for effectively screening and assessing agents for tumor immunotherapy, which includes assessment for the effects of target cells, non-target cells, and tumor infiltration. The system and method of the present application can be used to comprehensively and systematically assess the effectiveness and safety of the agent against tumor immune cells.

Abstract: A fetal head direction measuring device includes a medical ultrasonic probe for scanning and acquiring a preset ultrasonic image, an angle sensor fixed to the medical ultrasonic probe for sensing an angular change of a scanning direction of the medical ultrasonic probe, and a data processing unit for calculating a fetal head direction. A fetal head direction measuring method includes: obtaining an angle value sensed by the angle sensor at an initial position; acquiring a preset ultrasonic image and recording an angle value sensed by an angle sensor at this time; marking preset fetal head feature points and calculating a directional angle of the preset fetal head feature points in the preset ultrasonic image; and determining the fetal head direction. A fetal head orientation can be measured and calculated more conveniently and flexibly, and the user operation is simpler and more flexible.