Patents by Inventor You Seok Hwang
You Seok Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10941161Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.Type: GrantFiled: March 4, 2019Date of Patent: March 9, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Publication number: 20190225624Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.Type: ApplicationFiled: March 4, 2019Publication date: July 25, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Patent number: 10221196Abstract: Described herein are crystalline forms of a compound of formula (II?), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (II?): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.Type: GrantFiled: August 14, 2015Date of Patent: March 5, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Patent number: 10000510Abstract: This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.Type: GrantFiled: August 17, 2015Date of Patent: June 19, 2018Assignee: MERCK SHARP & DOHME CORP.Inventors: Jian-Qiao Gu, Valdas Jurkauskas, Carlos Lopez, Kristos Adrian Moshos, Pradip M. Pathare, Sudhakar Garad, You Seok Hwang
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Publication number: 20170233408Abstract: This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.Type: ApplicationFiled: August 17, 2015Publication date: August 17, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Jian-Qiao Gu, Valdas Jurkauskas, Carlos Lopez, Kristos Adrian Moshos, Pradip M. Pathare, Sudhakar Garad, You Seok Hwang
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Publication number: 20170226126Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (III?): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.Type: ApplicationFiled: August 14, 2015Publication date: August 10, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Publication number: 20160228448Abstract: Ceftolozane Sulfate is a cephalosporin antibacterial agent. Novel, stable, solid forms of the pharmaceutically acceptable sulfate salt of ceftolozane have been isolated via lyophilization. Characterization and identification of these solid forms by XRPD and Raman IR, as well as methods for their preparation and use in pharmaceutical compositions, are described.Type: ApplicationFiled: September 25, 2014Publication date: August 11, 2016Inventors: You Seok Hwang, Nicole Miller Damour, Lisa Duong, Valdas Jurkauskas, Kristos Adrian Moshos, Sanjay Mudur, Asli Ovat, Joseph Terracciano, Jason Woertink
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Patent number: 9120795Abstract: This disclosure provides compositions containing solid forms of sodium (2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate, and methods of manufacturing and using these compositions.Type: GrantFiled: March 14, 2014Date of Patent: September 1, 2015Assignee: Cubist Pharmaceuticals, Inc.Inventors: You Seok Hwang, Jian-Qiao Gu, Akash Jain, Sudhakar Garad, Jacob P. Sizemore
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Publication number: 20150111864Abstract: This disclosure provides compositions containing solid forms of (2S,5R)-2-(5-(3-aminopropyl)-1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate, and methods of manufacturing and using these compositions.Type: ApplicationFiled: October 2, 2014Publication date: April 23, 2015Inventors: Sudhakar Garad, Akash Jain, You Seok Hwang
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Publication number: 20150094293Abstract: Novel solid forms of ceftolozane are described, as well as methods for the preparation and use of these solid forms.Type: ApplicationFiled: May 28, 2014Publication date: April 2, 2015Applicant: CALIXA THERAPEUTICS, INC.Inventors: Valdas Jurkauskas, Nicole Miller Damour, Lisa Duong, You Seok Hwang, Kristos Adrian Moshos, Sanjay Mudur, Asli Ovat, Joseph Terracciano, Jason Woertink
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Patent number: 8906866Abstract: Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.Type: GrantFiled: March 15, 2013Date of Patent: December 9, 2014Assignees: BioSource Pharm, Inc., Cubist Pharmaceuticals, Inc.Inventors: William V. Curran, Christopher M. Liu, Amy C. D. Bombardier, Richard A. Leese, You Seok Hwang, Blaise S. Lippa, Yanzhi Zhang
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Patent number: 8906898Abstract: Novel solid forms of ceftolozane are described, as well as methods for the preparation and use of these solid forms.Type: GrantFiled: May 28, 2014Date of Patent: December 9, 2014Assignee: Calixa Therapeutics, Inc.Inventors: You Seok Hwang, Nicole Miller Damour, Lisa Duong, Valdas Jurkauskas, Kristos Adrian Moshos, Sanjay Mudur, Asli Ovat, Joseph Terracciano, Jason Woertink
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Publication number: 20140275001Abstract: This disclosure provides compositions containing solid forms of sodium (2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate, and methods of manufacturing and using these compositions.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Inventors: You Seok Hwang, Jian-Qiao Gu, Akash Jain, Sudhakar Garad, Jacob P. Sizemore
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Publication number: 20140163048Abstract: This disclosure describes solid forms of the compound of Formula (I) and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain.Type: ApplicationFiled: August 9, 2013Publication date: June 12, 2014Applicant: Cubist Pharmaceuticals, Inc.Inventors: Nicholas Barker, Jian-Qiao Gu, Gaauri NAIK, Jan-Ji LAI, Stephen MACHATHA, You Seok Hwang, Pradip M. Pathare
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Patent number: 8415307Abstract: Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.Type: GrantFiled: June 23, 2011Date of Patent: April 9, 2013Assignees: BioSource Pharm, Inc., Cubist Pharmaceuticals, Inc.Inventors: William V. Curran, Christopher M. Liu, Amy C. D. Bombardier, Richard A. Leese, You Seok Hwang, Blaise S. Lippa, Yanzhi Zhang
