Patents by Inventor Youcef M. Rustum

Youcef M. Rustum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic Uses of Elsiglutide
    Publication number: 20180177849
    Abstract: The invention relates to therapeutic uses of elsiglutide, particularly for protecting and stimulating bone marrow and peripheral blood cell type activity or immune-response in patients compromised due to the administration of chemotherapeutic agents. The invention further provides uses of elsiglutide to enhance the antitumor activity of cytotoxic chemotherapeutic agents and target specific biological agents.
    Type: Application
    Filed: October 6, 2017
    Publication date: June 28, 2018
    Inventors: Claudio Pietra, Emanuela Lovati, Youcef M. Rustum
  • Therapeutic Uses of Elsiglutide
    Publication number: 20170087216
    Abstract: The invention relates to therapeutic uses of elsiglutide, particularly for protecting and stimulating bone marrow and peripheral blood cell type activity or immune-response in patients compromised due to the administration of chemotherapeutic agents. The invention further provides uses of elsiglutide to enhance the antitumor activity of cytotoxic chemotherapeutic agents and target specific biological agents.
    Type: Application
    Filed: September 15, 2016
    Publication date: March 30, 2017
    Inventors: Claudio Pietra, Emanuela Lovati, Youcef M. Rustum
  • Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium
    Patent number: 7744854
    Abstract: This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: June 29, 2010
    Assignee: Health Research, Inc.
    Inventors: Youcef M. Rustum, Arup Bhattacharya, Karoly Toth, Harry K. Slocum, Rami G. Azrak, Sreenivasulu Chintala, Mukund Seshadri, Richard Mazurchuk
  • Method of reducing alopecia and bladder toxicity of cyclophosphamide
    Patent number: 7534818
    Abstract: The present invention discloses a method for reducing alopecia and bladder toxicity associated with the anti-cancer agent cyclophosphamide. The method comprises administering to an individual, in need of such a treatment, cyclophosphamide and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.
    Type: Grant
    Filed: September 15, 2003
    Date of Patent: May 19, 2009
    Assignee: Health Research, Inc.
    Inventors: Youcef M. Rustum, Shousong Cao, Farukh Durrani, Karoly Toth, Peter Kanter, Harry Slocum
  • Method of reducing toxicity of anticancer agents
    Patent number: 6939893
    Abstract: The present invention discloses a method for enhancing the efficacy of anti-cancer agents. The method comprises administering to an individual, in need of such a treatment, an anti-cancer agent and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: September 6, 2005
    Assignee: Health Research, Inc.
    Inventors: Youcef M. Rustum, Shousong Cao, Farukh Durrani
  • Method of reducing toxicity of anticancer agents
    Publication number: 20040180099
    Abstract: The present invention discloses a method for reducing the toxicity of anti-cancer agents oxaliplatin and doxorubicin. The method comprises administering to an individual, in need of such a treatment, the anti-cancer agent and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 16, 2004
    Inventors: Youcef M. Rustum, Shousong Cao, Farukh Durrani
  • Method of reducing toxicity of anticancer agents
    Publication number: 20040110838
    Abstract: The present invention discloses a method for enhancing the efficacy of anti-cancer agents. The method comprises administering to an individual, in need of such a treatment, an anti-cancer agent and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.
    Type: Application
    Filed: December 10, 2002
    Publication date: June 10, 2004
    Inventors: Youcef M. Rustum, Shousong Cao, Farukh Durrani