Patents by Inventor Youcef Rustum

Youcef Rustum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium
    Publication number: 20080019919
    Abstract: This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.
    Type: Application
    Filed: March 23, 2007
    Publication date: January 24, 2008
    Inventors: Youcef Rustum, Arup Bhattacharya, Karoly Toth, Harry Slocum, Rami Azrak, Sreenivasulu Chintala, Mukund Seshadri, Richard Mazurchuk
  • COMBINATION THERAPY USING PENTAFLUOROBENZENESULFONAMIDES AND ANTINEOPLASTIC AGENTS
    Publication number: 20070248692
    Abstract: Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent.
    Type: Application
    Filed: March 16, 2007
    Publication date: October 25, 2007
    Applicants: AMGEN INC., HEALTH RESEARCH, INC.
    Inventors: Fengzhi Li, Xiang Ling, Youcef Rustum, Susan Schwendner, Pieter Timmermans, Jacqueline Walling
  • Method of augmenting the antitumor activity of anticancer agents
    Publication number: 20060258697
    Abstract: A method for augmenting the antitumor activity of anti-cancer agents is provided. The method comprises administering to an individual an anti-cancer and a selenium compound. A method is also provided for inhibiting the growth of a tumor which-has proven to be refractory to anticancer agents. The methods comprises administration of selenium compound followed by administration of the anticancer agent.
    Type: Application
    Filed: April 17, 2006
    Publication date: November 16, 2006
    Inventors: Youcef Rustum, Shousong Cao, Farukh Durrani, Marwan Fakih
  • Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
    Publication number: 20050250854
    Abstract: Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent.
    Type: Application
    Filed: November 23, 2004
    Publication date: November 10, 2005
    Applicants: Amgen Inc., Health Research, Inc.
    Inventors: Fengzhi Li, Xiang Ling, Youcef Rustum, Susan Schwendner, Pieter Timmermans, Jacqueline Walling
  • Method of augmenting the antitumor activity of anticancer agents
    Publication number: 20050197399
    Abstract: A method for augmenting the antitumor activity of anti-cancer agents is provided. The method comprises administering to an individual an anti-cancer agent and a selenium compound. A method is also provided for inhibiting the growth of a tumor which has proven to be refractory to anticancer agents. The methods comprises administration of selenium compound followed by administration of the anticancer agent.
    Type: Application
    Filed: March 11, 2005
    Publication date: September 8, 2005
    Inventors: Marwan Fakih, Youcef Rustum, Lakshmi Pendyala, Patrick Smith
  • Method of augmenting the antitumor activity of anticancer agents
    Publication number: 20050026852
    Abstract: A method for augmenting the antitumor activity of anti-cancer agents is provided. The method comprises administering to an individual an anti-cancer agent and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.
    Type: Application
    Filed: May 13, 2004
    Publication date: February 3, 2005
    Inventors: Youcef Rustum, Shousong Cao, Farukh Durrani