Patents by Inventor Youichi Shiokawa
Youichi Shiokawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5508413Abstract: This invention relates to novel (+)-5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.More particularly, it relates to novel (+)-5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, which has pharmacological activities such as hypotensive and vasodilating activities, to a pharmaceutical composition comprising the same and to a method for treating hypertension, cardiovascular diseases, and the like.Accordingly, one object of this invention is to provide novel (+)-5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, which is of use for treating hyperxtension, cardiovascular diseases, and the like.Type: GrantFiled: March 22, 1991Date of Patent: April 16, 1996Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Kazuo Okumura
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Patent number: 5387710Abstract: This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with halogen, etc.,R.sup.2 is hydrogen, halogen, nitro, hydroxy, lower alkyl optionally substituted with acyl, lower alkenyl optionally substituted with acyl, lower alkoxy optionally substituted with acyl, or amino optionally substituted with acyl(lower)alkyl,R.sup.3 is hydrogen, an N-protective group, or lower alkyl optionally substituted with lower alkylthio,n is an integer of 0 to 3, anda heavy solid line means a single bond or a double bond,provided that when n is 1, then1) R.sup.1 is a condensed aromatic hydrocarbon group or a heterocyclic group, each of which may be substituted with halogen, etc.Type: GrantFiled: September 17, 1993Date of Patent: February 7, 1995Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Masanobu Nagano, Kiyoshi Taniguchi, Kazuhiko Take, Takeshi Kato, Kazunori Tsubaki
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Patent number: 5338743Abstract: The present method for the treatment of pancreatitis, which comprises administering an effective amount of a pyrazolopyridine compound of the following formula: ##STR1## wherein R.sup.1 is lower alkyl, (substituted) aryl, or a heterocyclic group,R.sup.2 is a group of the formula ##STR2## wherein R.sup.4 is protected amino or hydroxy and R.sup.5 is hydrogen or lower alkyl; cyano; a group of the formula --A--R.sup.6, wherein R.sup.6 is an acyl group, and A is (halogenated) lower aliphatic hydrocarbon group; amidated carboxy; an unsaturated heterocyclic group; or (protected) amino; andR.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen; or a pharmaceutically acceptable salt thereof, to a human being having pancreatitis or an animal having pancreatitis in need thereof.Type: GrantFiled: March 10, 1992Date of Patent: August 16, 1994Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5296490Abstract: The disclosure concerns pyrazolopyridine compounds of the formulawherein the variables are defined in the specification. The compounds are useful as a diuretic, anti-hypertensive agent, etc.Type: GrantFiled: October 30, 1992Date of Patent: March 22, 1994Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5256824Abstract: The compound (-)-N-t-butyl-4,4-diphenyl-2-cyclopentenylamine, or its hydrochloride salt has anticholinergic activity, and thus has a variety of pharmaceutical utilities.Type: GrantFiled: March 7, 1991Date of Patent: October 26, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Kazuo Okumura, Kazuhiko Take, Kazunori Tsubaki
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Patent number: 5234930Abstract: This invention relates to pyrazolopyridine compounds for the treatment of melancholia, heart failure, hypertension, renal insufficiency, renal toxicity, nephrosis, nephritis, edema, obesity, bronchial asthma, gout, hyperuricemia, sudden infant death syndrome, immunosuppression, diabetes, myocardial infarction, thrombosis, obstruction, arteriosclerosis obliterans, thrombophlebitis, cerebral infarction, transient ischemic attack or angina pectoris, said compounds being of the formula ##STR1## wherein the radicals are defined in the claims.Type: GrantFiled: April 9, 1992Date of Patent: August 10, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5204346Abstract: There are disclosed 3 [2(substituted alkyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-aryl pyrazolo [1,5-a]-pyridines useful for treating maladies requiring an adenosine antagonist, and preparative processes.Type: GrantFiled: July 15, 1991Date of Patent: April 20, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5192779Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s)R.sup.2 is aryl which may have one or more suitable substituent(s), lower alkyl or cyclo(lower)alkyl,R.sup.3 is hydrogen, hydroxy, halogen, lower alkenyl, amino or protected amino,R.sup.4 is a group of the formula: ##STR2## wherein R.sup.5 is lower alkyl which may have one or more suitable substituent(s), cyclo(lower)alkyl, aryl, ar(lower)alkyl which may have one or more suitable substituent(s), andR.sup.6 is hydrogen or lower alkyl; or N-containing heterocyclic group which may have one or more suitable substituent(s), andA is lower alkylene or lower alkynylene, in which R.sup.1 and R.sup.2 may be linked through an oxygen atom, their preparation and use in treatment of dysuria, and starting materials for their preparation.Type: GrantFiled: August 28, 1991Date of Patent: March 9, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Kazuo Okumura, Kazuhiko Take, Kazunori Tsubaki
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Patent number: 5179103Abstract: The disclosure deals with pyrazolopyridine compounds of the formula: ##STR1## wherein the variables are defined in the specification. The compounds are useful as a diuretic, anti-hypertensive agent, etc.Type: GrantFiled: October 22, 1991Date of Patent: January 12, 1993Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5155114Abstract: The invention relates to a method for the prevention and/or treatment of renal toxicity, nephrosis or nephritis, which comprises administering a pyrazolopyridine compound of the formula: ##STR1## wherein R.sup.1 is aryl, andR.sup.2 is unsaturated heterocyclic group which contains at least one heteroatom selected from the group consisting of N, O and S, which may have one or more suitable substituent(s), or a pharmaceutically acceptable salt thereof to a human being or an animal.Type: GrantFiled: June 14, 1991Date of Patent: October 13, 1992Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5104890Abstract: Benzopyrene derivatives effective for the treatment of hypertension have been prepared.Type: GrantFiled: March 8, 1990Date of Patent: April 14, 1992Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Youichi Shiokawa, Koichi Takimoto, Kohei Takenaka, Takeshi Kato
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Patent number: 5102869Abstract: The invention relates to a method for the treatment of renal toxicity, nephrosis or nephritis which comprises administering an effective amount of the pyrazolopyridine compounds of the invention.Type: GrantFiled: June 19, 1990Date of Patent: April 7, 1992Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5102878Abstract: The invention relates to a method for the treatment of ailments which comprises administering an effective amount of the pyrazolopyridine compounds of the invention.Type: GrantFiled: March 19, 1990Date of Patent: April 7, 1992Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5087629Abstract: The invention relates to novel pyrazolopyridine compounds useful as a diuretic, antihypertensive agaent, for renal insufficiency, for thrombosis, and as a cardiotonic agent.Type: GrantFiled: March 12, 1990Date of Patent: February 11, 1992Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atshushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 5066680Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s),R.sup.2 is aryl which may have one or more suitable substituent(s), lower alkyl or cyclo(lower)alkyl,R.sup.3 is hydrogen, hydroxy, halogen, lower alkenyl, amino or protected amino,R.sup.4 is a group of the formula: ##STR2## wherein R.sup.5 is lower alkyl which may have one or more suitable substituent(s), cyclo(lower)alkyl, aryl, ar(lower)alkyl which may have one or more suitable substituent(s), andR.sup.6 is hydrogen or lower alkyl; or N-containing heterocyclic group which may have one or more suitable substituent(s), andA is lower alkylene or lower alkynylene, in which R.sup.1 and R.sup.2 may be linked through oxygen atom, their preparation and use in treatment of dysuria, and starting materials for their preparation.Type: GrantFiled: February 5, 1990Date of Patent: November 19, 1991Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Kazuo Okumura, Kazuhiko Take, Kazunori Tsubaki
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Patent number: 5010093Abstract: The invention relates to a nitric ester derivative with vasodilating properties for treatment of cardiovascular disorders, the derivative being of the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, halo(lower)alkyl, halogen, phenyl, nitrophenyl, pyridyl, morpholino, piperidino, amino, lower alkanoylamino, higher alkanoylamino, benzamido, lower alkoxycarbonylamino, N-lower alkylamino, N,N-di(lower)alkylamino, N-lower alkyl-N-lower alkanoylamino, 3-lower alkylureido or N,N-di(lower) alkylamino(lower)alkyl,R.sup.2 is hydrogen, lower alkyl or N-(nitrooxy(lower)alkyl)carbamoyl,Y is a single bond, lower alkylene or lower alkenylene, andZ is ethylene, trimethylene, tetramethylene, 1-methylnitrooxymethylethylene, 1,1-bis(nitrooxy-methyl)ethylene, 2-nitrooxytrimethylene or ethyleneoxyethylene, and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 16, 1990Date of Patent: April 23, 1991Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Koichi Takimoto, Kohei Takenaka
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Patent number: 4994453Abstract: The disclosure deals with pyrazolopyridine compounds of the formula ##STR1## wherein the variables are defined in the specification. The compounds are useful in the treatment of bronchial asthma, immunosuppression, diabetes, etc.Type: GrantFiled: September 15, 1989Date of Patent: February 19, 1991Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 4988723Abstract: Benzopyran derivatives of formula (I) wherein the substituents are as defined herein are provided. The compounds possess vasodilating activity and are useful in the treatment of hypertension. Pharmaceutical compositions and methods of treating hypertension are also provided.Type: GrantFiled: May 17, 1989Date of Patent: January 29, 1991Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Koichi Takimoto, Kohei Takenaka, Takeshi Kato
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Patent number: 4985444Abstract: The invention relates to pyrazolopyridine compounds for the treatment of melancholia, heart failure, hypertension, renal insufficiency, edema, obesity, bronchial asthma, gout, hyperuricemia, sudden infant death syndrome, immunosuppression, diabetes, myocardiac infection, thrombosis, obstruction, arteriosclerosis obliterans, thrombophlebitis, cerebral infarction, transient ischemic attack or angina pectoris, said compounds being of the formula ##STR1## wherein R.sup.1 is aryl, andR.sup.2 is unsaturated heterocyclic group which contains at least one heteroatom selected from the group consisting of N, O and S, which may have one or more suitable substituent(s),or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 18, 1990Date of Patent: January 15, 1991Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
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Patent number: 4925849Abstract: The disclosure deals with a pyrazolopyridine compound of the formula ##STR1## wherein the variables are defined in the specification. The compounds are useful as a diuretic, antihypertensive agent, etc.Type: GrantFiled: June 6, 1988Date of Patent: May 15, 1990Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Youichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga