Patents by Inventor Youichiro Naito
Youichiro Naito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7112594Abstract: Compounds represented by the following general formula (I) wherein ring A is benzene, cyclohexane, pyridine, piperidine, a derivative thereof, imidazole, a derivative thereof, etc.; the ring B represents benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene, etc.; R1, R2 and R3 represent each hydrogen, alkyl, halogen, hydroxyl, alkoxy, etc.; W represents hydrogen, alkyl or hydroxycarbonylalkyl; X represents halogen, cyano, nitro, etc.; X? represents hydrogen, halogen, etc.; and Y represents alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl, etc.; salt thereof, and drugs comprising these compounds. Because of having an exellent effect of inhibiting activated lymphocyte proliferation, these compounds are usefull as preventives or remedies for various autoimmune diseases.Type: GrantFiled: August 9, 2001Date of Patent: September 26, 2006Assignee: Mitsubishi Pharma CorporationInventors: Hiroyuki Ushio, Youichiro Naito, Naoki Sugiyama, Takafumi Kawaguchi, Makio Ohtsuki, Kenji Chiba
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Patent number: 7015218Abstract: The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X? is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.Type: GrantFiled: February 10, 2000Date of Patent: March 21, 2006Assignee: Mitsubishi Pharma CorporationInventors: Hiroyuki Ushio, Seigo Ishibuchi, Youichiro Naito, Naoki Sugiyama, Takafumi Kawaguchi, Kenji Chiba, Makio Ohtsuki, Yoichi Naka
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Publication number: 20030203909Abstract: The present invention provides a compound represented by the formula (I) 1Type: ApplicationFiled: April 29, 2003Publication date: October 30, 2003Inventors: Hiroyuki Ushio, Youichiro Naito, Naoki Sugiyama, Takafumi Kawaguchi, Makio Ohtsuki, Kenji Chiba
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Patent number: 5750545Abstract: An agent for the prophylaxis and treatment of immune-related diseases, in particular, immunosuppressant, an agent for the prophylaxis and treatment of allergic diseases, an agent for the prophylaxis and treatment of eosinophil-related diseases and an eosinophilia inhibitor, comprising, as an active ingredient, a series of triazole derivatives of the following formula (I) ##STR1## or the following formula (III) ##STR2## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. A novel monocyclic or bicyclic triazole derivative. The agent for the prophylaxis and treatment of immune-related diseases, in particular, immunosuppressant, the agent for the prophylaxis and treatment of allergic diseases, the agent for the prophylaxis and treatment of eosinophil-related diseases, the eosinophilia inhibitor and the novel triazole derivative of the present invention all, have superior eosinophilia-inhibitory action and lymphocyte activation-inhibitory action.Type: GrantFiled: January 23, 1996Date of Patent: May 12, 1998Assignee: The Green Cross CorporationInventors: Fumihiko Akahoshi, Takehiro Okada, Shinji Takeda, Youichiro Naito, Chikara Fukaya, Shigeki Kuwahara, Masahiko Kajii, Hiroko Nishimura, Masanori Sugiura
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Patent number: 4933329Abstract: Novel bis-S-alkylbenzene derivatives capable of inhibiting lipoxygenase, inparticular, 5-lipoxygenase are disclosed. It is expected that the compounds, which are hardly metabolized in vivo, are highly useful in the treatment and/or prevention of various diseases, including allergic diseases such as asthma, inflammation, myocardial infarction, nephritis, scabies and gout.Type: GrantFiled: December 6, 1988Date of Patent: June 12, 1990Assignee: Green Cross CorporationInventors: Youichiro Naito, Yasunari Yamaura, Masanori Sugiura, Chikara Fukaya, Kazumasa Yokoyama
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Patent number: 4868201Abstract: 1-(fluoro- or perfluoro lower alkyl-substituted benzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester is found to have antiinflammatory and analgestic activity with less side effects on gastrointestinal traces than its homologue, acematacin or indometacin.Type: GrantFiled: April 27, 1987Date of Patent: September 19, 1989Assignee: The Green Cross CompanyInventors: Chikara Fukaya, Youichiro Naito, Shuichi Hanada, Masahiro Watanabe, Kazumasa Yokoyama
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Patent number: 4733002Abstract: A lipoxygenase inhibitor comprising as active ingredient a substituted styrene derivative having a radical of the general formula ##STR1## wherein X denotes a hydroxyl group or a lower alkoxy group and q is an integer of 2 or 3, and containing carbon atoms in total of at least 8.Type: GrantFiled: May 23, 1985Date of Patent: March 22, 1988Assignee: Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Masanori Sugiura, Youichiro Naito, Youichiro Nishida, Tadakazu Suyama
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Patent number: 4654337Abstract: A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.Type: GrantFiled: July 5, 1985Date of Patent: March 31, 1987Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama
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Patent number: 4613605Abstract: A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.Type: GrantFiled: July 5, 1985Date of Patent: September 23, 1986Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama
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Patent number: 4613614Abstract: There is provided a new ester of prostaglandin of the formula ##STR1## wherein R.sub.1 denotes an alkyl group having 1 to 20 carbon atoms; R.sub.2 denotes a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; and X denotes a group represented by the formula ##STR2## The new ester dissolves in oil easier than prostaglandin I.sub.2 itself and can easily be emulsified in the form of particles of solution in a vegetable oil. The ester in the fat emulsion is more stable than prostaglandin I.sub.2 and its physiological acts which are the same as prostaglandin I.sub.2 are prolonged.Type: GrantFiled: June 29, 1984Date of Patent: September 23, 1986Assignee: The Green Cross CorporationInventors: Chikara Fukaya, Youichiro Naito, Kazumasa Yokoyama
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Patent number: 4605786Abstract: A perfluoroether compound having the following formula is useful as a thermostable, inert solvent and inter alia as an oxygen carrier in an artificial blood or infusion fluid. ##STR1## wherein Rf.sub.1 and Rf.sub.2 are different from each other and are selected from the group of a C.sub.1 or C.sub.3 perfluoroalkyl group which may be interrupted by an oxygen atom, and a C.sub.5 -C.sub.7 perfluorocycloalkyl group, and n and n' are zero or an integer of 1; one of Rf.sub.1 and Rf.sub.2 being the C.sub.5 -C.sub.7 perfluorocycloalkyl group and the total number of carbon atoms being 9-11 inclusive.Type: GrantFiled: December 20, 1983Date of Patent: August 12, 1986Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Yoshihisa Inoue, Taizo Ono, Chikara Fukaya, Yoshio Arakawa, Youichiro Naito, Koichi Yamauchi, Tadakazu Suyama
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Patent number: 4605650Abstract: A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.Type: GrantFiled: July 5, 1983Date of Patent: August 12, 1986Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama
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Patent number: 4604385Abstract: A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.Type: GrantFiled: July 5, 1985Date of Patent: August 5, 1986Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama
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Patent number: 4542147Abstract: A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.Type: GrantFiled: June 17, 1983Date of Patent: September 17, 1985Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama
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Patent number: 4535085Abstract: A perfluorotricyclic amine compound which is usable as an oxygen carrier in an artificial blood, represented by the general formula ##STR1## wherein R denotes a perfluoroalkyl group having 1-4 carbon atoms; the ring A denotes a five- or six-membered ring, the ring B denotes a five-, six- or seven-membered ring, the ring C denotes a five- or six-membered ring any one of the rings A, B and C optionary being substituted by one or more lower perfluoroalkyl group in addition to the above-mentioned substituent R; and further f, g, h, i, j and k denote integers appropriately selected to construct the above-mentioned size of rings A, B, and C; is prepared by reacting the corresponding perhydrotricyclic amine with fluorine.Type: GrantFiled: March 29, 1983Date of Patent: August 13, 1985Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama
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Patent number: 4530926Abstract: A novel compound of the formula, ##STR1## wherein k, j, l and m are zero or an integer of from 1 to 3, and n is an integer of from 1 to 3, the rings A, B and C being optionally substituted with at least one trifluoromethyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.Type: GrantFiled: June 17, 1983Date of Patent: July 23, 1985Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama
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Patent number: 4425347Abstract: A perfluorobicyclo compound emulsion preparation having oxygen carrying ability containing a perfluorobicyclo compound of the general formula: ##STR1## wherein R represents a perfluoromethyl group or perfluoroethyl group, as an oxygen carrying component.Type: GrantFiled: December 28, 1982Date of Patent: January 10, 1984Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama
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Patent number: 4423061Abstract: A perfluorocycloamine emulsion preparation having oxygen carrying ability containing a perfluorocycloamine of the general formula: ##STR1## wherein any position may optionally be substituted with a perfluoromethyl group as an oxygen carrying component.Type: GrantFiled: December 28, 1982Date of Patent: December 27, 1983Assignee: The Green Cross CorporationInventors: Kazumasa Yokoyama, Chikara Fukaya, Yoshio Tsuda, Taizo Ono, Yoshio Arakawa, Yoshihisa Inoue, Youichiro Naito, Tadakazu Suyama