Abstract: A drug coating layer which ensures that when a medical device coated with a drug is delivered into a living body, the drug can be prevented from peeling off during delivery operation through a body lumen or cavity such as a blood vessel; and/or a drug coating layer excellent in transferability of a drug to a target tissue; and a method of controlling the morphological form of a drug coating layer are provided.

Abstract: The present invention relates to a tetrahydroisoquinoline derivative represented by the following formula 1 exhibiting an inhibitory action for agglutination caused by fibrinogen, which may be effectively used as an antithrombotic agent or a platelet agglutination-inhibiting agent. The present invention also relates to a medical preparation containing such compound. ##STR1## In formula 1, B and G are an alkylene optionally substituted with an alkyl or the like; D is H, an alkyl, or the like; E is 1,2,3,4-tetrahydroisoquinoline optionally substituted with R.sub.1 to R.sub.4 which binds to G at position 2; R.sub.1 to R.sub.4 are an alkyl or the like; L is hydroxy or the like; and A is a substituent represented by formula (2), and C is carbon. ##STR2## In formula 2, M and R.sub.5 to R.sub.8 are H, an alkyl or the like.