Patents by Inventor Youmin Shu
Youmin Shu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120231969Abstract: Illustrative embodiments herein disclosed relate to protein arrays, methods for making the arrays and methods for using them, among others. In some embodiments known proteins representing at least 50% of the loci in the human genome are arrayed in known positions on a support. In some embodiments arrays are made of proteins purified from cell lysates by affinity binding to the support. In some embodiments protein arrays are used to decode the binding specificity of antibodies. In some embodiments protein arrays are used to diagnose auto-immune disorders. Many other embodiments and general features are disclosed.Type: ApplicationFiled: September 23, 2010Publication date: September 13, 2012Applicant: Origene Technologies, Inc.Inventors: Wei-Wu He, Donghui Ma, Youmin Shu, Zairen Sun
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Publication number: 20060241015Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially expressed in prostate and breast cancers and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., cancers.Type: ApplicationFiled: January 24, 2003Publication date: October 26, 2006Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl Kovacs, Wufang Fan, Youmin Shu
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Patent number: 7115393Abstract: The present invention relates to all facets of novel polynucleotides for melanocortin-1 receptors, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially relating to melanocortin-1, such as melanoma, pigmentation disorders and conditions, inflammation, etc.Type: GrantFiled: June 10, 2002Date of Patent: October 3, 2006Assignee: OriGene Technologies, Inc.Inventors: Youmin Shu, Xuan Li, Anthony C. Yee, Gilbert Jay
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Publication number: 20060026700Abstract: The present invention relates to genes and genes clusters which are expressed in a tissue specific maner. For example, the invention relates to a group of genes encoding GPCR-like receptors that are involved in the function and activity of the immune system. These genes are organized into a discrete cluster at chromosomal location 1q22 (the “immune gene complex”) and span about 700 kb of DNA. The region closest to the centromere comprises genes that are expressed predominantly in the thymus, while the distal region comprises genes which are expressed predominantly in the bone marrow and other hematopoietic cells. Another cluster of GPCR genes is located at chromosomal band 11q24. These genes are expressed predominantly in pancreatic tissue, establishing this region of chromosome 11 as a unique gene complex involved in pancreatic function. A cluster of transmembrane and GPCR-type receptor genes is also located at chromosomal band 11q12.2.Type: ApplicationFiled: April 15, 2003Publication date: February 2, 2006Applicant: Origene Technologies, Inc.Inventors: Gilbert Jay, Richard Lebovitz, Youmin Shu, Zairen Sun, Meng Wu
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Publication number: 20050120855Abstract: The present invention relates to all facets of a novel cutting tool designed to retrieving gel slice from an agarose gel and poly-acrylamide gel. The cutting tool is made of plastics or metal materials and consists of a tool body and a plug. The upper end of the rectangle tube is open. A plug is inserted into the rectangle tube from the upper end of the tube to form the cutting tool. The rectangle shape and the plug of the cutting tool make gel-cutting and gel-ejecting much easier and more precise.Type: ApplicationFiled: December 6, 2003Publication date: June 9, 2005Inventor: Youmin Shu
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Publication number: 20050120393Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in prostate and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to prostate, such as prostate cancers, as well as other disease and conditions.Type: ApplicationFiled: August 2, 2002Publication date: June 2, 2005Applicant: OriGene Technologies, Inc.Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl Kovacs, Youmin Shu, Wufang Fan
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Publication number: 20050055733Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in small intestine or colon and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to small intestine or colon.Type: ApplicationFiled: July 8, 2002Publication date: March 10, 2005Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl Kovacs, Youmin Shu, Wufang Fan
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Publication number: 20050019818Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.Type: ApplicationFiled: August 20, 2004Publication date: January 27, 2005Inventors: Youmin Shu, Wufang Fan, Karl Kovacs, Xuan Li, Gilbert Jay
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Patent number: 6780595Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.Type: GrantFiled: February 26, 2002Date of Patent: August 24, 2004Assignee: Origene Technologies, Inc.Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Publication number: 20030235826Abstract: The present invention relates to OTB182, and all facets of novel polynucleotides encoded by it, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in excitable tissues, such as heart, brain, and muscle, and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, such neuropathy, neuralgic amyotrophy (e.g., HNA), myopathy, sensorineural hearing loss (e.g., DFNA20), mental retardation, neuromuscular disorders, and other diseases especially relating to excitable tissues, such as heart, brain, and muscle.Type: ApplicationFiled: June 24, 2002Publication date: December 25, 2003Inventors: Youmin Shu, Xuan Li, Gilbert Jay
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Publication number: 20030232339Abstract: The present invention relates to all facets of a novel polynucleotide, TRPCC, the polypeptides it encodes, antibodies, and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in brain, kidney, pituitary, and other tissues, and are therefore useful in a variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to brain and/or kidney disease, including diseases and conditions such as hypomagnesemia, hypocalcemia, and amyotrophic lateral sclerosis with frontotemporal dementia, etc.Type: ApplicationFiled: June 13, 2002Publication date: December 18, 2003Inventors: Youmin Shu, Xuan Li, Gilbert Jay
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Publication number: 20030228658Abstract: The present invention relates to all facets of novel polynucleotides for melanocortin-1 receptors, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially relating to melanocortin-1, such as melanoma, pigmentation disorders and conditions, inflammation, etc. The identification of a specific genes expressed in pathways physiologically relevant to pigmentation and inflammation permits the definition of functional and disease pathways, and the delineation of targets in these pathways which are useful in diagnostic, therapeutic, and clinical applications.Type: ApplicationFiled: June 10, 2002Publication date: December 11, 2003Inventors: Youmin Shu, Xuan Li, Anthony C. Yee, Gilbert Jay
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Publication number: 20030203866Abstract: The present invention relates to a group of genes involved in the function and activity of the immune system. These genes are organized into a discrete cluster at chromosomal location 1q22 (the “immune gene complex”). See, FIGS. 1 and 2. The region closest to the centromere comprises genes that are expressed predominantly in the thymus, while the distal region comprises genes which are expressed predominantly in the bone marrow and other hematopoietic cells. These genes comprise members of the olfactory GPCR family which are expressed predominantly in immune system cells.Type: ApplicationFiled: August 30, 2002Publication date: October 30, 2003Inventors: Richard M. Lebovitz, Youmin Shu, Xuan Liu, Meng Wu, Gilbert Jay
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Publication number: 20030170639Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in liver and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, such as hepatitis and carcinoma, especially relating to liver.Type: ApplicationFiled: March 11, 2002Publication date: September 11, 2003Inventors: Youmin Shu, Gilbert Jay
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Publication number: 20030162177Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.Type: ApplicationFiled: February 26, 2002Publication date: August 28, 2003Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Publication number: 20030096271Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, especially relating to brain and pancreas.Type: ApplicationFiled: July 15, 2002Publication date: May 22, 2003Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Michael Zidanic, Gilbert Jay
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Publication number: 20030092036Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, especially relating to brain and pancreas.Type: ApplicationFiled: July 15, 2002Publication date: May 15, 2003Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Michael Zidanic, Gilbert Jay
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Publication number: 20030082548Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in thalamus and testes and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, such as Parkinsonian manifestations (e.g., tremor), neurogenic pain, depression, tinnitis, epilepsy, obsessive-compulsive disorder, dystonia, and spasticity, especially relating to thalamus and testes.Type: ApplicationFiled: August 31, 2001Publication date: May 1, 2003Inventors: Youmin Shu, Wufang Fan, Gilbert Jay
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Publication number: 20030078199Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides and polypeptides are related to EphA6, and are expressed in brain, pancreas, and testes tissues and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, especially relating to brain, pancreas, and testes tissues.Type: ApplicationFiled: October 9, 2001Publication date: April 24, 2003Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Michael Zidanic, Xuan Li, Gilbert Jay
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Patent number: 6455292Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to diseases and conditions, especially relating to brain and pancreas.Type: GrantFiled: August 16, 2001Date of Patent: September 24, 2002Assignee: OriGene Technologies, IncInventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Michael Zidanic, Gilbert Jay