Patents by Inventor Youming Zhang

Youming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170233750
    Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.
    Type: Application
    Filed: December 27, 2016
    Publication date: August 17, 2017
    Inventors: Youming Zhang, Jun Fu, Xiaoying Bian, Adrian Francis Stewart, Rolf Muller
  • Publication number: 20170139969
    Abstract: A method for filtering and analyzing big data and electronic device are provided. The method includes multiple rounds of filtering and analyzing. Each round of filtering and analyzing includes: filtering and analyzing a set of data to be filtered, according to a filtering dimension which was not selected; and saving data corresponding to at least one dimension item under the filtering dimension and satisfying at least one target requirement as a set of data to be filtered in a next round of filtering and analyzing. The number of the multiple rounds of filtering and analyzing is determined based on the number of filtering dimensions and target requirements. Accordingly, a system will not crash due to being heavily loaded with large amount of data, and the accuracy of filtering and analyzing is improved.
    Type: Application
    Filed: August 26, 2016
    Publication date: May 18, 2017
    Inventors: Youming Zhang, Meng Zhou
  • Publication number: 20170140003
    Abstract: Disclosed are techniques for creating individual user profile, including: detecting behaviors of a user and assigning the user with various labels; determining a reference value of each attribute derived from each label based on the number and/or timeliness of a label assigned to the user within a period, an attribute derived from each label using the rules of derivation and the logical strength values of the rules of derivation; comparing the reference value of one of the attributes derived from each label with a predetermined threshold to judge whether or not it can be determined that the user attributes include the one of the attributes, determining, if not, it is judged whether it can be determined that the user attributes include the one of the attributes using the reference value as well as reference values of the attribute under other labels; and completing a user profile.
    Type: Application
    Filed: August 26, 2016
    Publication date: May 18, 2017
    Inventor: Youming Zhang
  • Publication number: 20170142119
    Abstract: Techniques are disclosed for creating a group user profile to improve group user profiling accuracy, including: detecting behaviors of each user in a target user group based on a label-attribute-weight library including labels, attributes under the labels, and reference attribute weights, and assigning each user with corresponding labels; determining, by referring to the label-attribute-weight library, attribute weights of attributes under labels for each user in the target user group, weight-averaging the attribute weights based on types of the attributes, and determining the attribute weights of various attributes of the target user group; and creating a group user profile of the target user group based on the determined attribute weights of various attributes of the target user group. The disclosure also provides a system for creating a group user profile.
    Type: Application
    Filed: August 26, 2016
    Publication date: May 18, 2017
    Inventor: Youming Zhang
  • Patent number: 9580717
    Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 28, 2017
    Assignee: Gene Bridges GmbH
    Inventors: Youming Zhang, Jun Fu, Xiaoying Bian, Adrian Francis Stewart, Rolf Müller
  • Publication number: 20150267210
    Abstract: The present invention provides a method of preparing electrocompetent cells from Gram-negative bacteria characterized in that the bacteria are prepared under room temperature. Also provided are electrocompetent Gram-negative bacteria and kits which comprise the electrocompetent bacteria.
    Type: Application
    Filed: October 15, 2013
    Publication date: September 24, 2015
    Inventors: Rolf Mueller, Qiang Tu, Youming Zhang, Francis Stewart, Jun Fu
  • Patent number: 8728820
    Abstract: The invention provides a method for inserting a single stranded replacement nucleic acid into a target nucleic acid, the method comprising the steps of: a) generating a single stranded replacement nucleic acid from a double stranded nucleic acid, wherein the double stranded nucleic acid is adapted at one or both of its 5? ends such that preferential degradation of one strand and/or strand separation generates the single stranded replacement nucleic acid, wherein the single stranded replacement nucleic acid comprises a 5? region that is identical to sequence on the target nucleic acid, a 3? region that is identical to sequence on the target nucleic acid and optionally a replacement region between the 5? and 3? regions that is not identical to sequence on the target nucleic acid, b) exposing the target nucleic acid to the single stranded replacement nucleic acid under conditions suitable for recombination to occur between the single stranded replacement nucleic acid and the target nucleic acid, and c) selecting
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: May 20, 2014
    Assignee: Gene Bridges GmbH
    Inventors: Marcello Maresca, Axel Steffen Erler, Jun Fu, Philipp Martin Seibert, Adrian Francis Stewart, Youming Zhang
  • Publication number: 20130210681
    Abstract: A method for performing homologous recombination between at least a first nucleic acid molecule and a second nucleic acid molecule which share at least one region of sequence homology. A method for improving the efficiency of homologous recombination.
    Type: Application
    Filed: June 10, 2011
    Publication date: August 15, 2013
    Inventors: Youming Zhang, Jun Fu, Adrian Francis Stewart
  • Publication number: 20130089522
    Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.
    Type: Application
    Filed: December 17, 2010
    Publication date: April 11, 2013
    Applicant: GENE BRIDGES GMBH
    Inventors: Youming Zhang, Jun Fu, Xiaoying Bian, Francis Stewart, Rolf Muller
  • Publication number: 20120208277
    Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.
    Type: Application
    Filed: January 3, 2012
    Publication date: August 16, 2012
    Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)
    Inventors: Francis STEWART, Youming ZHANG, Frank BUCHHOLZ
  • Patent number: 7736851
    Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: June 15, 2010
    Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)
    Inventors: Francis Stewart, Youming Zhang, Frank Buchholz
  • Publication number: 20090298117
    Abstract: The invention provides a method for the heterologous expression of a secondary metabolite encoded by a biosynthetic pathway. Also provided is a method for introducing a large sized DNA molecule into the chromosome of a heterologous host using a transposable element. Novel myxochromide S derivatives are also provided.
    Type: Application
    Filed: October 26, 2005
    Publication date: December 3, 2009
    Inventors: Youming Zhang, Rolf Müller, Francis Stewart, Frank Gross, Silke C. Wenzel, Jun Fu
  • Publication number: 20090007280
    Abstract: The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic acid sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.
    Type: Application
    Filed: March 11, 2008
    Publication date: January 1, 2009
    Inventors: Youming Zhang, Miriam Moffatt, William Cookson, Jon Tinsley
  • Patent number: 7364864
    Abstract: The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic acid sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: April 29, 2008
    Assignee: Isis Innovation Limited
    Inventors: Youming Zhang, Miriam Moffatt, William Cookson, Jon Tinsley
  • Publication number: 20060257928
    Abstract: The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic acid sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.
    Type: Application
    Filed: November 3, 2005
    Publication date: November 16, 2006
    Inventors: Youming Zhang, Miriam Moffatt, William Cookson, Jon Tinsley
  • Patent number: 7083976
    Abstract: The present invention is directed to methods and compositions for TnpI-mediated genetic engineering using the Bacillus thuringiensis recombinase TnpI and the TnpI recombination substrates TRT or TRT?, and variants thereof. In particular, the invention relates to TRT or TRT? sequences, and variants thereof, vectors, cells and kits useful for TnpI-mediated genetic recombination, as well as methods for the use of TRT or TRT? sequences for TnpI-mediated genetic engineering.
    Type: Grant
    Filed: June 30, 2001
    Date of Patent: August 1, 2006
    Assignees: The European Molecular Biology Laboratory, l 'Universite catholique de Louvain
    Inventors: A. Francis Stewart, Youming Zhang, Bernard Hallet
  • Patent number: 6930094
    Abstract: The present invention relates to the use of tissue factor for influencing blood vessel formation, particularly for activating blood vessel formation, above all for wound healing.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: August 16, 2005
    Assignee: Merckle GmbH
    Inventors: Peter Nawroth, Katsumi Nakagawa, Youming Zhang
  • Publication number: 20050085627
    Abstract: The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic add sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.
    Type: Application
    Filed: June 21, 2002
    Publication date: April 21, 2005
    Inventors: Youming Zhang, Miriam Moffatt, William Cookson, Jon Tinsley
  • Publication number: 20040203057
    Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.
    Type: Application
    Filed: May 11, 2004
    Publication date: October 14, 2004
    Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)
    Inventors: Francis Stewart, Youming Zhang, Frank Buchholz
  • Patent number: 6787316
    Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: September 7, 2004
    Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)
    Inventors: Francis Stewart, Youming Zhang, Frank Buchholz