Patents by Inventor Youming Zhang
Youming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170233750Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.Type: ApplicationFiled: December 27, 2016Publication date: August 17, 2017Inventors: Youming Zhang, Jun Fu, Xiaoying Bian, Adrian Francis Stewart, Rolf Muller
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Publication number: 20170139969Abstract: A method for filtering and analyzing big data and electronic device are provided. The method includes multiple rounds of filtering and analyzing. Each round of filtering and analyzing includes: filtering and analyzing a set of data to be filtered, according to a filtering dimension which was not selected; and saving data corresponding to at least one dimension item under the filtering dimension and satisfying at least one target requirement as a set of data to be filtered in a next round of filtering and analyzing. The number of the multiple rounds of filtering and analyzing is determined based on the number of filtering dimensions and target requirements. Accordingly, a system will not crash due to being heavily loaded with large amount of data, and the accuracy of filtering and analyzing is improved.Type: ApplicationFiled: August 26, 2016Publication date: May 18, 2017Inventors: Youming Zhang, Meng Zhou
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Publication number: 20170140003Abstract: Disclosed are techniques for creating individual user profile, including: detecting behaviors of a user and assigning the user with various labels; determining a reference value of each attribute derived from each label based on the number and/or timeliness of a label assigned to the user within a period, an attribute derived from each label using the rules of derivation and the logical strength values of the rules of derivation; comparing the reference value of one of the attributes derived from each label with a predetermined threshold to judge whether or not it can be determined that the user attributes include the one of the attributes, determining, if not, it is judged whether it can be determined that the user attributes include the one of the attributes using the reference value as well as reference values of the attribute under other labels; and completing a user profile.Type: ApplicationFiled: August 26, 2016Publication date: May 18, 2017Inventor: Youming Zhang
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Publication number: 20170142119Abstract: Techniques are disclosed for creating a group user profile to improve group user profiling accuracy, including: detecting behaviors of each user in a target user group based on a label-attribute-weight library including labels, attributes under the labels, and reference attribute weights, and assigning each user with corresponding labels; determining, by referring to the label-attribute-weight library, attribute weights of attributes under labels for each user in the target user group, weight-averaging the attribute weights based on types of the attributes, and determining the attribute weights of various attributes of the target user group; and creating a group user profile of the target user group based on the determined attribute weights of various attributes of the target user group. The disclosure also provides a system for creating a group user profile.Type: ApplicationFiled: August 26, 2016Publication date: May 18, 2017Inventor: Youming Zhang
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Patent number: 9580717Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.Type: GrantFiled: December 17, 2010Date of Patent: February 28, 2017Assignee: Gene Bridges GmbHInventors: Youming Zhang, Jun Fu, Xiaoying Bian, Adrian Francis Stewart, Rolf Müller
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Publication number: 20150267210Abstract: The present invention provides a method of preparing electrocompetent cells from Gram-negative bacteria characterized in that the bacteria are prepared under room temperature. Also provided are electrocompetent Gram-negative bacteria and kits which comprise the electrocompetent bacteria.Type: ApplicationFiled: October 15, 2013Publication date: September 24, 2015Inventors: Rolf Mueller, Qiang Tu, Youming Zhang, Francis Stewart, Jun Fu
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Patent number: 8728820Abstract: The invention provides a method for inserting a single stranded replacement nucleic acid into a target nucleic acid, the method comprising the steps of: a) generating a single stranded replacement nucleic acid from a double stranded nucleic acid, wherein the double stranded nucleic acid is adapted at one or both of its 5? ends such that preferential degradation of one strand and/or strand separation generates the single stranded replacement nucleic acid, wherein the single stranded replacement nucleic acid comprises a 5? region that is identical to sequence on the target nucleic acid, a 3? region that is identical to sequence on the target nucleic acid and optionally a replacement region between the 5? and 3? regions that is not identical to sequence on the target nucleic acid, b) exposing the target nucleic acid to the single stranded replacement nucleic acid under conditions suitable for recombination to occur between the single stranded replacement nucleic acid and the target nucleic acid, and c) selectingType: GrantFiled: February 20, 2009Date of Patent: May 20, 2014Assignee: Gene Bridges GmbHInventors: Marcello Maresca, Axel Steffen Erler, Jun Fu, Philipp Martin Seibert, Adrian Francis Stewart, Youming Zhang
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Publication number: 20130210681Abstract: A method for performing homologous recombination between at least a first nucleic acid molecule and a second nucleic acid molecule which share at least one region of sequence homology. A method for improving the efficiency of homologous recombination.Type: ApplicationFiled: June 10, 2011Publication date: August 15, 2013Inventors: Youming Zhang, Jun Fu, Adrian Francis Stewart
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Publication number: 20130089522Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.Type: ApplicationFiled: December 17, 2010Publication date: April 11, 2013Applicant: GENE BRIDGES GMBHInventors: Youming Zhang, Jun Fu, Xiaoying Bian, Francis Stewart, Rolf Muller
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Publication number: 20120208277Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: ApplicationFiled: January 3, 2012Publication date: August 16, 2012Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis STEWART, Youming ZHANG, Frank BUCHHOLZ
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Patent number: 7736851Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: GrantFiled: May 11, 2004Date of Patent: June 15, 2010Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis Stewart, Youming Zhang, Frank Buchholz
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Publication number: 20090298117Abstract: The invention provides a method for the heterologous expression of a secondary metabolite encoded by a biosynthetic pathway. Also provided is a method for introducing a large sized DNA molecule into the chromosome of a heterologous host using a transposable element. Novel myxochromide S derivatives are also provided.Type: ApplicationFiled: October 26, 2005Publication date: December 3, 2009Inventors: Youming Zhang, Rolf Müller, Francis Stewart, Frank Gross, Silke C. Wenzel, Jun Fu
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Publication number: 20090007280Abstract: The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic acid sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.Type: ApplicationFiled: March 11, 2008Publication date: January 1, 2009Inventors: Youming Zhang, Miriam Moffatt, William Cookson, Jon Tinsley
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Patent number: 7364864Abstract: The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic acid sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.Type: GrantFiled: November 3, 2005Date of Patent: April 29, 2008Assignee: Isis Innovation LimitedInventors: Youming Zhang, Miriam Moffatt, William Cookson, Jon Tinsley
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Publication number: 20060257928Abstract: The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic acid sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.Type: ApplicationFiled: November 3, 2005Publication date: November 16, 2006Inventors: Youming Zhang, Miriam Moffatt, William Cookson, Jon Tinsley
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Patent number: 7083976Abstract: The present invention is directed to methods and compositions for TnpI-mediated genetic engineering using the Bacillus thuringiensis recombinase TnpI and the TnpI recombination substrates TRT or TRT?, and variants thereof. In particular, the invention relates to TRT or TRT? sequences, and variants thereof, vectors, cells and kits useful for TnpI-mediated genetic recombination, as well as methods for the use of TRT or TRT? sequences for TnpI-mediated genetic engineering.Type: GrantFiled: June 30, 2001Date of Patent: August 1, 2006Assignees: The European Molecular Biology Laboratory, l 'Universite catholique de LouvainInventors: A. Francis Stewart, Youming Zhang, Bernard Hallet
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Patent number: 6930094Abstract: The present invention relates to the use of tissue factor for influencing blood vessel formation, particularly for activating blood vessel formation, above all for wound healing.Type: GrantFiled: May 8, 1998Date of Patent: August 16, 2005Assignee: Merckle GmbHInventors: Peter Nawroth, Katsumi Nakagawa, Youming Zhang
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Publication number: 20050085627Abstract: The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic add sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.Type: ApplicationFiled: June 21, 2002Publication date: April 21, 2005Inventors: Youming Zhang, Miriam Moffatt, William Cookson, Jon Tinsley
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Publication number: 20040203057Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: ApplicationFiled: May 11, 2004Publication date: October 14, 2004Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis Stewart, Youming Zhang, Frank Buchholz
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Patent number: 6787316Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: GrantFiled: August 30, 2002Date of Patent: September 7, 2004Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis Stewart, Youming Zhang, Frank Buchholz