Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Abstract: A method for producing a supported catalyst useful in polymerization of ethylene and copolymerization of ethylene and &agr;-olefin is disclosed. The method includes treating the magnesium-containing carrier with a titanium compound containing oxygen atom(s), wherein said carrier is obtained by reaction of an organomagnesium compound of the structure of MgPh2.nMgCl2.mR2O (n=0.37˜0.7; m≧1; R20=ether; Ph=phenyl) with an organic chloride compound in a mole ratio of organic chloride compound/Mg≧0.5, at −20˜80° C. In one embodiment, the organic chloride compound may be carbon tetrachloride. A specific catalyst is provided whose activity is low in the beginning but slowly rises to a sufficient degree as the process of polymerization progresses, the polymer produced with the use of said catalyst having high bulk density, a well adjusted particle size distribution, and a narrow molecular weight distribution.

Abstract: The present invention relates to a catalyst for polymerization or copolymerization of an olefin. The catalyst is produced by first reacting a mixture of a magnesium compound and an aluminum compound with an ester compound which has at least one hydroxy group and a silane compound which has at least one alkoxy group, and next reacting with a titanium compound. The catalyst may be used in the polymerization or copolymerization of ethylene and propylene.

Abstract: The present invention relates to a method for producing a Ti/V supported catalyst useful in polymerization of ethylene and copolymerization of ethylene and &agr;-olefin. The method includes a treatment, by a titanium compound and a vanadium compound, of the magnesium-containing carrier, which is obtained by reaction of an organomagnesium compound of the structure of MgPh2.nMgCl2.mR2O (n=0.37˜0.7; m≧1; R2O=ether; Ph=phenyl) with an organic chloride compound in a mole ratio of organic chloride compound/Mg≧0.5, at −20˜80° C. According to the method for producing the catalyst, it is possible to provide a catalyst which can control the distribution of molecular weight, and when polymerization is performed using this catalyst, it is possible to restrain the inactivation and to secure a sufficient activity. Moreover, the polymer produced by the use of this catalyst proves to have a high bulk density and an adjusted particle size distribution.