Patents by Inventor Young Choon-Moon

Young Choon-Moon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of 1,2,4-oxadiazole benzoic acids
    Patent number: 7678922
    Abstract: Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: March 16, 2010
    Assignee: PTC Therapeutics, Inc.
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Seemon Pines, Young-Choon Moon, James J. Takasugi
  • PROCESSES FOR THE PREPARATION OF 1,2,4-OXADIAZOLE BENZOIC ACIDS
    Publication number: 20100063297
    Abstract: Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.
    Type: Application
    Filed: November 13, 2009
    Publication date: March 11, 2010
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Seemon Pines, Young-Choon Moon, James J. Takasugi
  • Carboline derivatives useful in the inhibition of angiogenesis
    Patent number: 7601840
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: October 13, 2009
    Assignee: PTC Therapeutics, Inc.
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson, Seongwoo Hwang
  • Carboline Derivatives Useful in the Inhibition of Angiogenesis
    Publication number: 20090227618
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Application
    Filed: March 15, 2005
    Publication date: September 10, 2009
    Applicant: PTC Therapeutics, Inc.
    Inventors: Young-Choon MOON, Liangxian CAO, Nadarajan TAMILARASU, Hongyan QI, Soongyu CHOI, William LENNOX, Donald CORSON, Seongwoo HWANG
  • Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control
    Publication number: 20090042866
    Abstract: The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.
    Type: Application
    Filed: November 23, 2005
    Publication date: February 12, 2009
    Inventors: William Lennox, Hongyan Qi, Duck-Hyung Lee, Soongyu Choi, Young-Choon Moon
  • Compositions useful as protein kinase inhibitors
    Patent number: 7456190
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: November 25, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Francois Maltais, Alex Aronov, Michael R. Hale, Young-Choon Moon
  • Substituted Phenols as Active Agents Inhibiting Vegf Production
    Publication number: 20080261956
    Abstract: The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.
    Type: Application
    Filed: November 23, 2005
    Publication date: October 23, 2008
    Inventors: Soongyu Choi, Young-Choon Moon, Nadarajan Tamilarasu
  • 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, compositions, and methods for the use thereof
    Patent number: 7419991
    Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: September 2, 2008
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary Mitchell Karp, Seongwoo Hwang, Guangming Chen, Neil Gregory Almstead, Young-Choon Moon
  • Tetra-Cyclic Carboline Derivatives Useful in the Inhibition of Angiogenesis
    Publication number: 20080182866
    Abstract: In accordance with the present invention, tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Application
    Filed: March 15, 2005
    Publication date: July 31, 2008
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson
  • Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-YL]-benzoic acid
    Publication number: 20080171377
    Abstract: The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.
    Type: Application
    Filed: September 24, 2007
    Publication date: July 17, 2008
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Young-Choon Moon
  • Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, composistions thereof and the use for nonsense suppression
    Publication number: 20080139632
    Abstract: Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Application
    Filed: September 24, 2007
    Publication date: June 12, 2008
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Young-Choon Moon, Ellen M. Welch
  • Processes for the preparation of 1,2,4-oxadiazole benzoic acids
    Publication number: 20080139818
    Abstract: Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.
    Type: Application
    Filed: September 6, 2007
    Publication date: June 12, 2008
    Inventors: Neil G. Almstead, Peter Seongwoo Hwang, Seemon Pines, Young-Choon Moon, James J. Takasugi
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Patent number: 7361665
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein R1, R2, A, G, and W are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli, Lck, Src, and Aurora kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: April 22, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Ledeboer, Jian Wang, Young Choon Moon
  • Compositions useful as inhibitors of JAK and other protein kinases
    Patent number: 7348335
    Abstract: The present invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: March 25, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Randy S. Bethiel, Young-Choon Moon
  • Carboline Derivatives Useful in the Inhibition of Angiogenesis
    Publication number: 20070281962
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Application
    Filed: March 15, 2005
    Publication date: December 6, 2007
    Applicant: PCT Therapeutics, Inc.
    Inventors: Young-Choon MOON, Liangxian CAO, Nadarajan TAMILARASU, Hongyan QI, Soongyu CHOI, William LENNOX, Donald CORSON, Seongwoo HWANG
  • Substituted 1,2,4-oxadiazoles, compositions and methods of use
    Patent number: 7304080
    Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: December 4, 2007
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary Mitchell Karp, Seongwoo Hwang, Guangming Chen, Neil Gregory Almstead, Young-Choon Moon
  • 1,2,4-Oxadiazole benzoic acid compositions and their use for nonsense suppression and the treatment of disease
    Publication number: 20070161687
    Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Application
    Filed: March 14, 2007
    Publication date: July 12, 2007
    Inventors: Gary Karp, Seongwoo Hwang, Guangming Chen, Neil Almstead, Young-Choon Moon
  • Compositions useful as inhibitors of protein kinases
    Patent number: 7226919
    Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3, JAK-3, FLT-3, PIM-1, SYK, or PDK-1 mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: June 5, 2007
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Mark Ledeboer, Robert Davies, David Messersmith, Young-Choon Moon, Michael Mullican
  • 4-Substituted-5-cyano-1H-pyrimidin-6-(thi)ones as GSK-3 inhibitors
    Patent number: 7217712
    Abstract: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various GSK-3-mediated disorders, such as diabetes and Alzheimer's disease.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: May 15, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: Young-Choon Moon
  • Benzoic acid or benzoate substituted 1,2,4-oxadiazole compounds and their use for the treatment of disease
    Patent number: 7202262
    Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: April 10, 2007
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary Mitchell Karp, Seongwoo Hwang, Guangming Chen, Neil Gregory Almstead, Young-Choon Moon