Abstract: The present invention provides methods and compositions to improve the efficiency of somatic cell nuclear transfer (SCNT) of human cells and the consequent production of human nuclear transfer ESC (hNT-ESCs). More specifically, the present invention relates to the discovery that trimethylation of Histone H3-Lysine 9 (H3K9me3) in reprogramming resistant regions (RRRs) in the nuclear genetic material of human donor somatic cells prevents efficient human somatic cell nuclear reprogramming or SCNT. The present invention provide methods and compositions to decrease H3K9me3 in methods to improve efficacy of hSCNT by exogenous or overexpression of the demethylase KDM4 family and/or inhibiting methylation of H3K9me3 by inhibiting the histone methyltransferases SUV39h1 and/or SUV39h2.

Abstract: The present invention provides methods and compositions to improve the efficiency of somatic cell nuclear transfer (SCNT) of human cells and the consequent production of human nuclear transfer ESC (hNT-ESCs). More specifically, the present invention relates to the discovery that trimethylation of Histone H3-Lysine 9 (H3K9me3) in reprogramming resistant regions (RRRs) in the nuclear genetic material of human donor somatic cells prevents efficient human somatic cell nuclear reprogramming or SCNT. The present invention provide methods and compositions to decrease H3K9me3 in methods to improve efficacy of hSCNT by exogenous or overexpression of the demethylase KDM4 family and/or inhibiting methylation of H3K9me3 by inhibiting the histone methyltransferases SUV39h1 and/or SUV39h2.

Abstract: A coating and method of making, using, and applying the coating to protect structures from scratches and/or the undesired collection of slag and/or spatter associated with metal working processes. The coating includes a base layer and a top layer that, when applied, mitigate adhesion of weld slag to the underlying structure. The coating is also transparent such that it does not interfere with the functionality of any indicia associated with the underlying structure or device and also renders the coating suitable for use with photo-reactive or responsive sensors and/or other non-opaque structures—such as goggles, facemasks, and/or shields.

Abstract: The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo.

Abstract: A coating and method of making, using, and applying the coating to protect structures from scratches and/or the undesired collection of slag and/or spatter associated with metal working processes. The coating includes a base layer and a top layer that, when applied, mitigate adhesion of weld slag to the underlying structure. The coating is also transparent such that it does not interfere with the functionality of any indicia associated with the underlying structure or device and also renders the coating suitable for use with photo-reactive or responsive sensors and/or other non-opaque structures—such as goggles, facemasks, and/or shields.

Abstract: This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.

Abstract: This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.

Abstract: This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.

Abstract: The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo.

Abstract: This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.

Abstract: A lead frame for making a semiconductor package is disclosed. The leadframe's leads include a lead lock provided at a free end of each inner lead that is adapted to increase a bonding force of the inner lead to a resin encapsulate, thereby effectively preventing a separation of the inner lead from occurring in a singulation process involved in the fabrication of the semiconductor package. A semiconductor package fabricated using the lead frame and a fabrication method for the semiconductor package are also disclosed.

Abstract: A layered construction for application to a device or substrate or placement in an enclosed space for use in decontaminating the underlying surface or enclosed space comprises a cathode, an electrolyte layer, an anode and a protective surface layer. A compound that can be electrically decomposed to release on demand and over an extended period of time, an oxidant is included in the layered structure, preferably in the electrolyte layer. Preferred compounds are those which can release halogen ions which react with various different chemical or biological contaminants which may contact the protective layer, destroying, or devitalizing the contaminants.

Abstract: Provided is a method of preparing a cyclic olefin polymer by addition polymerization of a cyclic olefin monomer, the method including contacting a metal catalyst complex represented by Formula 1 below with a cyclic olefin monomer represented by Formula 2 below: [M(L1)x(L?2)y(L3)z]a[Ani]b ??<Formula 1> wherein M is a Group X metal; [M(L1)x(L?2)y(L3)z] is a cationic complex; L1 is an anionic hydrocarbyl-containing ligand; L?2 is a neutral ligand; L3 is an N-heterocyclic carbene ligand; [Ani] is an anion capable of weakly coordinating with the metal M; x is 1 or 2; y is 0 to 4; z is 1 or 2; 2?x+y+z?6; a and b are respectively the number of cations and the number of anions capable of weakly coordinating with the metal M and are each a number of 1-10 which is used to satisfy the net charge balance of the metal catalyst complex, and wherein for each of L1, L?2, and L3, when a plurality of ligands are present in a molecule of the metal catalyst complex, the ligands may be the same or different, and where

Abstract: A semiconductor thin film using a self-assembled monolayer (SAM) and a method for producing the semiconductor thin film are provided. According to the semiconductor thin film, a uniform inorganic seed layer is formed by using the self-assembled monolayer so that the adhesion between an insulating layer and a semiconductor layer is enhanced and thus the surface tension is reduced, thereby allowing the semiconductor thin film to have high quality without defects.

Abstract: Techniques are provided for sensing a first current produced by an active circuit component. According to these techniques, a current sensor is disposed over the active circuit component. The current sensor includes a Magnetic Tunnel Junction (“MTJ”) core disposed between a first conductive layer and a second conductive layer. The MTJ core can be used to sense the first current and produce a second current based on the first current sensed at the MTJ core.

Abstract: An integrated circuit device is provided which includes an active circuit component and a current sensor. The active circuit component may be coupled between a first conductive layer and a second conductive layer, and is configured to produce a first current. The current sensor is disposed over the active circuit component. The current sensor may comprise a Magnetic Tunnel Junction (“MTJ”) core disposed between the first conductive layer and the second conductive layer. The MTJ core is configured to sense the first current and produce a second current based on the first current sensed at the MTJ core.

Abstract: An integrated circuit device is provided which comprises a substrate, a conductive line configured to experience a pressure, and a magnetic tunnel junction (“MTJ”) core formed between the substrate and the current line. The conductive line is configured to move in response to the pressure, and carries a current which generates a magnetic field. The MTJ core has a resistance value which varies based on the magnetic field. The resistance of the MTJ core therefore varies with respect to changes in the pressure. The MTJ core is configured to produce an electrical output signal which varies as a function of the pressure.

Abstract: Provided is a metal catalyst complex for preparing a cyclic olefin-based polymer by addition polymerization of a cyclic olefin-based monomer, which is represented by Formula 1 below: [M(L1)x(L?2)y(L3)z]a[Ani]b ??<Formula 1> wherein M is a Group X metal; [M(L1)x(L?2)y(L3)z] is a cationic precatalyst; L1 is an anionic hydrocarbyl-containing ligand; L?2 is a neutral ligand; L3 is an N-heterocyclic carbene ligand; [Ani] is an anion capable of weakly coordinating with the metal M; x is 1 or 2; y is 0 to 4; z is 1 or 2; 2?x+y+z?6; a and b are each 1 to 10. The metal catalyst complex has an N-heterocyclic carbene ligand, and thus, is excellent in thermal stability and reactivity.

Abstract: A segmented, rigid-rod aromatic polyimide mixed with a UV curable acrylate photopolymer material comprises an alignment layer for aligning nematic polymeric liquid crystal compensator films. The material may also provide an out-of-plane retardation. The segmented, rigid-rod aromatic polyimide-based UV curable acrylate alignment layer, when applied in appropriate thickness, functions as a negative uniaxial C-plate compensator and causes alignment of the nematic liquid crystal molecules. The combination of the retardation provided by the alignment layer and the compensator film deposited on it provides a significant improvement in the contrast and color stability of liquid crystal displays (LCDs) at large viewing angles.

Abstract: An adhesion promoter for enhancing the bond between adjacent layers of a multilayer structure to prevent delamination thereof is disclosed. The adhesion promoter comprises an aromatic polyimide-based UV-cured acrylate. Also disclosed are laminated structures including liquid crystal displays and bonded missile domes that utilize an adhesion promoter of the invention, and methods for fabricating such structures.