Patents by Inventor Young-Don Kwak

Young-Don Kwak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of biasing implanted human neural stem cells away from differentiation into glial cells by (+)phenserine to modulate the concentration of soluble ?APP in tissue or CSF
    Patent number: 9095573
    Abstract: Disclosed herein are methods and materials for promoting neurogenesis of endogenous and transplanted stem cells. Specifically exemplified herein are methods that comprise transplanting neural stem cells in conjunction with a regimen of (+)phenserine treatment.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: August 4, 2015
    Inventors: Kiminobu Sugaya, Amelia Marutle, Young Don Kwak
  • METHOD AND SYSTEM FOR BIASING CELLULAR DEVELOPMENT
    Publication number: 20100196326
    Abstract: Compositions and methods comprising siRNA targeted to APP mRNA are advantageously used to transfect stem cells and bias the cells against differentiating into glial type neural cells. The siRNA of the invention causes RNAi-mediated silencing of the APP mRNA. The inventors have discovered that expression APP induces gliogenesis, i.e., promotes differentiation of potent cells into glial cells. The transfection of potent cells with the subject siRNA silences APP mRNA and thus increases probability of the cells to differentiate into non-glial neural cells.
    Type: Application
    Filed: March 23, 2009
    Publication date: August 5, 2010
    Inventors: Kiminobu Sugaya, Angel Alvarez, Young-Don Kwak
  • Method and system for biasing cellular development
    Publication number: 20060110440
    Abstract: Compositions and methods comprising siRNA targeted to APP mRNA are advantageously used to transfect stem cells and bias the cells against differentiating into glial type neural cells. The siRNA of the invention causes RNAi-mediated silencing of the APP mRNA. The inventors have discovered that expression APP induces gliogenesis, i.e., promotes differentiation of potent cells into glial cells. The transfection of potent cells with the subject siRNA silences APP mRNA and thus increases probability of the cells to differentiate into non-glial neural cells.
    Type: Application
    Filed: October 24, 2005
    Publication date: May 25, 2006
    Inventors: Kiminobu Sugaya, Angel Alvarez, Young-Don Kwak