Abstract: The present invention relates to an antibody-drug conjugate comprising an exosome secretion inhibitor conjugated to an antibody for inhibiting immune checkpoints, and the use thereof for treating cancer. An antibody-drug conjugate according to the present invention is maintained, in normal tissue, in a form in which a drug is conjugated to an antibody, and releases the drug upon reaching a cancer microenvironment, thereby inhibiting the secretion of cancer exosomes that cause an immunosuppressive mechanism. Thus the antibody-drug conjugate exhibits high therapeutic efficacy and can remarkably increase the objective response rate to an immune checkpoint inhibitor.

Abstract: A method for removing etchant byproduct from an etch reactor and discharging a substrate from an electrostatic chuck of the etch reactor is provided. One or more layers on a substrate electrostatically secured to an electrostatic chuck within a chamber of the etch reactor is etched using a first plasma, causing an etchant byproduct to be generated. A portion of the one or more layers are covered by a photoresist. After the etching is complete, a second plasma is provided into the chamber for a time period sufficient to trim the photoresist and remove a portion of the etchant byproduct. A second time period sufficient to electrostatically discharge the substrate using the second plasma is determined. Responsive to deactivating one or more chucking electrodes of the electrostatic chuck, the second plasma is provided into the chamber for the second time period and the substrate is removed from the chamber.

Abstract: A semiconductor chip may include: a body portion with a front surface and a rear surface; a pair of through electrodes penetrating the body portion; an insulating layer disposed over the rear surface of the body portion and the pair of through electrodes; and a rear connection electrode disposed over the insulating layer and connected simultaneously with the pair of through electrodes, wherein a distance between the pair of through electrodes is greater than twice a thickness of the insulating layer.

Abstract: The present invention relates to a method for producing induced dopaminergic neuronal progenitors from adult cells using direct reprogramming, induced dopaminergic neuronal progenitors produced via the method and a use for same, wherein, as a result of having been directly reprogrammed from adult cells, the induced dopaminergic neuronal progenitors produced by means of the present invention can be transplanted inside a living body without the risk of oncogenicity, and have excellent proliferative capacity and dopaminergic neuronal differentiation potency, thus can be usefully utilized as a cell therapy product for Parkinson's disease.

Abstract: A display device includes: a display panel; and a first substrate connected to the display panel, wherein the first substrate comprises: a first base substrate; a first wiring layer having a plurality of first signal wirings on the first base substrate; and a first ground wiring layer on the first wiring layer, wherein the first ground wiring layer comprises a mesh pattern area and a non-mesh pattern area, wherein the mesh pattern area comprises a plurality of first mesh patterns and openings surrounded by adjacent first mesh patterns, and the non-mesh pattern area comprises a plurality of second mesh patterns and non-mesh patterns surrounded by adjacent second mesh patterns, wherein the non-mesh patterns are physically connected to the adjacent second mesh patterns.

Abstract: A bicycle transmission using a variable speed motor and a planetary gear mechanism includes: a first input rotary shaft (10) rotatably connected to a main power source (11); a second input rotary shaft (20) receiving a motor rotational power from a variable speed motor (21); a planetary gear mechanism (30) receiving first and second rotational power respectively from the first input rotary shaft (10) and the second input rotary shaft (20), wherein the planetary gear mechanism (30) includes a ring gear (33), a carrier (31), a plurality of planet gears (32), and a sun gear (34); an output shaft (40) receiving a third rotational power from the planetary gear mechanism (30); and a control unit (50) controlling the variable speed motor (21) and controlling a rotational direction and speed of the second input rotary shaft (20).

Abstract: Provided are an injectable intraocular microgel and an injectable intraocular hydrogel that are safe to a human body and that can release a drug in the eye for a long period of time. This injectable intraocular microgel may have a form in which a drug is loaded on a hyaluronic acid microgel generated by causing hyaluronic acid copolymers to cross-link with each other through a w/o emulsion method.

Abstract: Provided is a robot cleaner using an artificial intelligence (AI) algorithm and/or a machine learning algorithm in a 5G environment connected for Internet of Things (IoT). The robot cleaner includes one or more sensors, a driving wheel, a suction blower, and a controller, and the controller defines a cleaning target area, identifies a user's location and a type of the user's behavior, collects life pattern information of the user including the user's location, the type of the user's behavior, and timestamps each associated therewith during the time period of one day or more, determines a cleaning schedule of the robot cleaner based on the collected life pattern information, and controls the driving wheel and the suction blower so as to perform cleaning in accordance with the determined cleaning schedule.

Abstract: A method for removing etchant byproduct from an etch reactor and discharging a substrate from an electrostatic chuck of the etch reactor is provided. A substrate may be electrostatically secured to an electrostatic chuck within a chamber of an etch reactor. A first plasma may be provided into the chamber to etch the substrate, causing an etchant byproduct to be generated. After the etching is complete, a second plasma may be provided into the chamber, wherein the second plasma is an oxygen containing plasma. The etchant byproduct may be removed and the first substrate may be discharged using the second plasma. The first substrate may be removed from the chamber and a second substrate may be inserted into the chamber without first performing an in-situ cleaning between the removal of the first substrate and the insertion of the second substrate.

Abstract: A semiconductor chip includes a body portion with a front surface and a rear surface; a through electrode penetrating the body portion; a wiring portion that is disposed over the front surface of the body portion; a rear connection electrode that is disposed over the rear surface of the body portion; and a front connection electrode that is disposed over the wiring portion, wherein the rear connection electrode includes a power rear connection electrode that is simultaneously connected to two or more power through electrodes, and wherein a width of the power rear connection electrode is greater than a width of the front connection electrode.

Abstract: Provided are a process for preparing a pyrimidinyl bipyridine compound having high purity with high yields without using high-cost silica gels, and an intermediate used therein.

Abstract: An electric vehicle including the Rankine cycle in which a circulation system of working fluid is formed is proposed. The Rankine cycle includes a pump configured to circulate the working fluid along the circulation system, a heat source comprising a battery unit, a motor unit, and a solar panel unit to transmit thermal energy to the working fluid circulated by the pump, a power generating unit provided on a path of the circulation system to generate electric energy through the thermal energy of the working fluid passing through the heat source, and a radiator configured to perform a heat exchange process between the working fluid passing through the power generating unit and outside air. The Rankine cycle further includes a flow distributor to distribute the working fluid circulated by the pump to at least any one of the battery unit, the motor unit, and the solar panel unit.

Abstract: A structural adhesive composition having high elongation and impact resistance contains an epoxy resin, a urethane resin formed by using a polyol comprising a long chain as a functional group, and an epoxy curing agent.

Abstract: A method for evaluating phase stability of an electrode mixture slurry, including the steps of: (S1) introducing the electrode mixture slurry to a rheometer; (S2) applying a first shear rate to the electrode mixture slurry; (S3) applying a second shear rate after applying the first shear rate to the electrode mixture slurry, wherein the second shear rate is higher than the first shear rate; (S4) applying a third shear rate after applying the second shear rate to the electrode mixture slurry, wherein the third shear rate is lower than the second shear rate; and (S5) comparing the shear viscosity at the first shear rate with the shear viscosity at the third shear rate. An apparatus for evaluating phase stability of the electrode mixture slurry is also provided.

Abstract: The present invention relates to an apparatus and method for monitoring a dry state of an electrode substrate in which electrode slurry is applied to a collector. The monitoring method comprises emitting light onto a surface of the electrode substrate; receiving the light reflected by the surface of the electrode substrate; and analyzing a luminous intensity or spectrum of the received light to estimate a drying rate of the electrode substrate. The apparatus includes a light emitting part emitting light from a light source onto a surface of the electrode substrate; a light receiving part receiving the light reflected by the surface of the electrode substrate; and a computing device analyzing a luminous intensity or spectrum of the received light and comparing analyzed characteristics of the light with the reference data of the reflected light to the drying rate of the electrode substrate.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating myositis. More particularly, the present invention relates to a pharmaceutical composition for preventing or treating myositis, comprising mitochondria as an active ingredient. When the pharmaceutical composition of the present invention comprising exogenous mitochondria as an active ingredient is administered to a subject suffering from myositis, inflammatory cells infiltrated into the muscle cells of the subject can be reduced. In addition, the pharmaceutical composition of the present invention effectively inhibits the expression of IL-1?, TNF-?, and IL-6, inflammatory cytokines. Therefore, the pharmaceutical composition according to the present invention can be usefully used for preventing or treating myositis.

Abstract: The present invention relates to a pharmaceutical composition for the treatment of sepsis or systemic inflammatory response syndrome (SIRS) comprising mitochondria as effective ingredient. When activated macrophages and monocytes are treated with mitochondria which are effective ingredient of the pharmaceutical composition of the present invention, expression of IL-1?, TNF-? and IL-6 which are pro-inflammatory cytokines can be restored to normal levels. Furthermore, when the pharmaceutical composition of the present invention is administered to a subject suffering from sepsis, the survival rate of the subject can be remarkably increased. Therefore, the pharmaceutical composition according to the present invention can be useful for the treatment of sepsis.

Abstract: A semiconductor chip according to an embodiment includes a body portion with a front surface and a rear surface, the body portion being oriented in such a way that the rear surface is above the front surface, first and second through electrodes penetrating the body portion with protrusions that protrude above the rear surface of the body portion, a wiring portion formed under the front surface of the body portion, a power pattern formed over the rear surface of the body portion and spaced apart from the protrusions, an interlayer insulating layer filling spaces between the power pattern and the protrusions, and first and second rear connection electrodes formed over the interlayer insulating layer and respectively connected to the first and second through electrodes, wherein the first rear connection electrode is simultaneously connected to the first through electrode and a part of the power pattern that is adjacent to the first through electrode.

Abstract: A multilayer electronic component according to an embodiment of the present disclosure includes: an electronic component body including a body having a dielectric layer and an internal electrode, and an external electrode disposed on the body; and a coating layer disposed on an external surface of the electronic component body, including one or more of silicon (Si) and fluorine (F), and having an average thickness of 5 nm or more and 15 nm or less.

Abstract: A method for collecting particles or gaseous chemicals is provided. The method includes providing liquid to a tube of a droplet generator, heating, with a heater of the droplet generator, the tube to provide vapor to a gas flow channel inside the tube, passing a gas flow containing the particles or gaseous chemicals through the gas flow channel inside the tube to obtain droplets including the particles or gaseous chemicals, and passing the droplets including the particles or gaseous chemicals to a wall of a collecting device such that the droplets including the particles or gaseous chemicals hit the wall. The temperature inside the gas flow channel is higher than a temperature inside the collecting device.