Patents by Inventor Young Joo Sun

Young Joo Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal Structure of The Human G267s Calpain-5 Protease Core Domain and Its Use in Rational Drug Design for Identifying Inhibitors of Calpain-5
    Publication number: 20240120032
    Abstract: A high-resolution crystallographic structure of the mutant human G267S calpain-5 protease core domain at 2.22 ? resolution is provided. The G267S mutation is associated with hyperactivity of calpain-5 and is linked to the inherited disease, neovascular inflammatory vitreoretinopathy. Methods of using the crystallographic structure in rational design of small molecule drugs that inhibit calpain-5 for treatment of retinal diseases and other diseases associated with calpain-5 hyperactivity are also provided.
    Type: Application
    Filed: October 14, 2021
    Publication date: April 11, 2024
    Inventors: Vinit Mahajan, Young Joo Sun, Gabriel Velez, Dylan Parsons
  • COMPOSITIONS AND METHODS FOR MEASURING AND INHIBITING CALPAIN-5 ACTIVITY
    Publication number: 20220364142
    Abstract: Compositions, methods, and kits are provided for assaying calpain-5 activity and inhibition. In particular, novel peptide substrates are provided for detecting calpain-5, measuring calpain-5 activity, and screening for inhibitors of calpain-5 to identify potential therapeutic agents for treating retinal diseases and other diseases associated with calpain-5 hyperactivity. Additionally, novel inhibitors of calpain-5 are also provided.
    Type: Application
    Filed: October 9, 2020
    Publication date: November 17, 2022
    Inventors: Vinit Mahajan, Gabriel Velez, Young Joo Sun, Kellie A Schaefer, Alexander G Bassuk