Patents by Inventor Young Jun Koh

Young Jun Koh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-c-Met/anti-EGFR bispecific antibodies
    Patent number: 9657104
    Abstract: There are provided an anti-c-Met/anti-EGFR bispecific antibody, a method for treating cancer using the same, and an anti-EGFR scFv fragment.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: May 23, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Mi Young Cho, Seung Hyun Lee, Kwang Ho Cheong, Powei Lin, Jae Woong Hwang, Christina Yi, Young Jun Koh
  • Method of target membrane protein depletion
    Patent number: 9388243
    Abstract: A method of target membrane protein depletion comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein and target membrane protein are associated with the cell membrane where the target membrane protein positions, and are internalized into a cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein; as well as related methods and compositions.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: July 12, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Kwang Ho Cheong, Seung Hyun Lee, Mi Young Cho, Young Jun Koh, Lin Powei, Christina Yi, Jae Woong Hwang
  • Bispecific chimeric proteins comprising DARPins
    Patent number: 9359440
    Abstract: A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof, linked to the DARPin; a method for treating or preventing cancer using the same; and related methods and compositions.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: June 7, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Kwang Ho Cheong, Young Jun Koh, Min-Kyung Kim, Powei Lin, Seung Hyun Lee, Jung Wook Lee, Mi Young Cho, Jae Woong Hwang
  • COMBINATION THERAPY USING BISPECIFIC ANTI-C-MET/ANTI-EGFR ANTIBODY AND C-SRC INHIBITOR
    Publication number: 20150216972
    Abstract: Pharmaceutical composition including a bispecific anti-c-Met/anti-EGFR antibody and a c-Src inhibitor and a method of preventing and/or treating cancer including co-administering a bispecific anti-c-Met/anti-EGFR antibody and a c-Src inhibitor to a subject in need thereof.
    Type: Application
    Filed: January 20, 2015
    Publication date: August 6, 2015
    Inventors: Powei Lin, Kwang Ho Cheong, Young Jun Koh, Jae-woong Hwang, Seung Hyun Lee, Jung Wook Lee
  • FUSION PROTEIN CAPABLE OF BINDING VEGF-A AND TNF-ALPHA
    Publication number: 20150183864
    Abstract: The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1.
    Type: Application
    Filed: November 12, 2014
    Publication date: July 2, 2015
    Inventors: KEEHOON JUNG, YOUNG JUN KOH, GYUN MIN LEE, SUN CHANG KIM, GOU YOUNG KOH
  • ANTI-EGFR ANTIBODY AND ANTI-C-MET/ANTI-EGFR BISPECIFIC ANTIBODIES COMPRISING THE SAME
    Publication number: 20150030599
    Abstract: An anti-EGFR scFV fragment, an anti-c-Met/anti-EGFR bispecific antibody including the same, and a method of preventing and/or treating a cancer using the same are provided.
    Type: Application
    Filed: July 29, 2014
    Publication date: January 29, 2015
    Inventors: Mi Young CHO, Seung Hyun Lee, Kwang Ho Cheong, Young Jun Koh, Jung Wook Lee, Powei Lin, Jae Woong Hwang
  • BISPECIFIC CHIMERIC PROTEINS WITH DARPins
    Publication number: 20150030596
    Abstract: A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof, linked to the DARPin; a method for treating or preventing cancer using the same; and related methods and compositions.
    Type: Application
    Filed: July 28, 2014
    Publication date: January 29, 2015
    Inventors: Kwang Ho CHEONG, Young Jun Koh, Min-Kyung Kim, Powei Lin, Seung Hyun Lee, Jung Wook Lee, Mi Young Cho, Jae Woong Hwang
  • Fusion protein capable of binding VEGF-A and TNF-alpha
    Patent number: 8927232
    Abstract: The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: January 6, 2015
    Assignee: Korea Advanced Institute of Science and Technology (KAIST)
    Inventors: Keehoon Jung, Young Jun Koh, Gyun Min Lee, Sun Chang Kim, Gou Young Koh
  • COMPOSITION FOR TARGET MEMBRANE PROTEIN DEPLETION
    Publication number: 20140356366
    Abstract: A method of target membrane protein depletion comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein and target membrane protein are associated with the cell membrane where the target membrane protein positions, and are internalized into a cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein; as well as related methods and compositions.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 4, 2014
    Applicant: Samsung Electronics Co., Ltd.
    Inventors: Kwang Ho CHEONG, Seung Hyun Lee, Mi Young Cho, Young Jun Koh, Lin Powei, Christina Yi, Jae Woong Hwang
  • ANTI-C-MET/ANTI-EGFR BISPECIFIC ANTIBODIES
    Publication number: 20140302029
    Abstract: There are provided an anti-c-Met/anti-EGFR bispecific antibody, a method for preventing and/or treating cancer using the same, and an anti-EGFR scFv fragment.
    Type: Application
    Filed: March 31, 2014
    Publication date: October 9, 2014
    Inventors: MI YOUNG CHO, SEUNG HYUN LEE, KWANG HO CHEONG, POWEI LIN, JAE WOONG HWANG, CHRISTINA YI, YOUNG JUN KOH
  • BISPECIFIC ANTI-CMET/ANTI-HER2 ANTIBODIES
    Publication number: 20140294838
    Abstract: There are provided an anti-c-Met/anti-Her2 bispecific antibody, and a method for preventing and/or treating cancer using the same.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 2, 2014
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Mi Young CHO, Powei Lin, Seung Hyun Lee, Kwang Ho Cheong, Young Jun Koh, Christina Yi, Jae Woong Hwang
  • FUSION PROTEIN CAPABLE OF BINDING VEGF-A AND TNF-ALPHA
    Publication number: 20100150926
    Abstract: The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1.
    Type: Application
    Filed: December 11, 2009
    Publication date: June 17, 2010
    Inventors: Keehoon JUNG, Young Jun Koh, Gyun Min Lee, Sun Chang Kim, Gou Young Koh
  • FUSION PROTEINS BINDING TO VEGF AND ANGIOPOIETIN
    Publication number: 20080242587
    Abstract: The present application discloses an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and Angiopoietin polypeptide, which includes a nucleotide sequence encoding a Tie2 component and a VEGFR component.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 2, 2008
    Inventors: Hak-Zoo Kim, Young Jun Koh, Ho-Min Kim, Keehoon Jung, Choonjoo Jeon, Gou Young Koh