Abstract: A drug delivery device, which is to be attached to the exterior wall of a vascular vessel, includes: a) a biocompatible device body for surrounding a vascular vessel; b) one or plurality of biocompatible microneedle, which are connected to the interior of the biocompatible device body and capable of penetrating up to the tunica media so as to deliver drug to the vascular smooth muscle cells. The drug delivery device and method enable spatial and temporal control of the drug ejected onto the blood cells and enable insertions of two or more different drugs at different delivery speeds and durations, thereby significantly improving the treatment success rate.