Publication number: 20220348663
Abstract: Provided are an anti-B7-H3 antibody binding specifically to B7-H3 and a use thereof and, more particularly, are an anti-B7-H3 antibody or an antigen binding fragment thereof, a nucleic acid encoding the same, a vector carrying the nucleic acid, a cell transformed with the vector, a method for preparing the same, an antibody-drug conjugate or a multi-specific antibody comprising the same, and a pharmaceutical composition for preventing or treating cancer, autoimmune disease, or inflammatory disease, or a diagnostic composition, each composition comprising the same. The anti-B7-H3 antibody or antigen binding fragment thereof can bind to human and non-human B7-H3 at high affinity and can be endocytosized after binding thereto. Thus, the anti-B7-H3 antibody or antigen binding fragment thereof, or the antibody-drug conjugate or the multi-specific antibody comprising the same can be advantageously used for preventing, treating, or diagnosing cancer or tumor, autoimmune disease, or inflammatory disease.
Type:
Application
Filed:
July 8, 2020
Publication date:
November 3, 2022
Inventors:
Hyun Ju LEE, Eun-Young SHIM, Yunjung KO, Jin-Chul YOUN, Jae Eun PARK, Soo A CHOI, Seok Ho YOO, Dong Jung LEE, Yeung-Chul KIM, Youngja SONG, Jisu LEE, Ju-Ry LIM, Bum-Chan PARK, Young Woo PARK
Publication number: 20220047717
Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.
Type:
Application
Filed:
June 25, 2021
Publication date:
February 17, 2022
Inventors:
Taekyo Park, Sunyoung Kim, Suho Park, Doohwan Jung, Donghoon Seo, Sangkwang Lee, Sanghyeon Yun, Jihyeon Ha, Hyang Sook Lee, Okku Park, Beomseok Seo, Sena Kim, Minah Seol, Jina Song, Sung Ho Woo, Jongun Cho, Jaeho Lee, Hyun Mi Lee, Jae Eun Park, Youngja Song, Eunjin Lee, Hyun Ju Lee, Eun-Young Shim, Yunjung Ko, Minju Lee, Young Woo Park, Yosup Rew