Abstract: Provided are an oxazole derivative, a preparation method therefor, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating an allergic disease such as asthma or atopy, where the oxazole derivative exhibits an excellent inhibitory effect on the intracellular signaling of IL-33 and thus can be advantageously used as an active ingredient in a pharmaceutical composition for prevention or treatment of an allergic disease such as asthma or atopy.

Abstract: HTS screening was performed regarding cell proliferation, one of symptoms of senescence. As a result, KB1541, which was the most effective on cell proliferation, was earned. The present invention described how the compound regulates cell proliferation and senescence. The present invention uncovered what proteins interacted with the compound using streptavidin-magnetic beads after treating with biotin-connected KB1541. Consequently, it was identified that mitochondrial proteins interacted with the compound. In ATP assay, electron microscope and IP assay, the inventors identified that the compound regulated mitochondrial proteins and thereby increased ATP production as well as recovered senescence.

Abstract: The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.