Patents by Inventor Young Mee Jung
Young Mee Jung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11920118Abstract: Provided are a method for fabricating a highly elastic porous polymer membrane, a method for manufacturing a cell culture system using a porous polymer membrane fabricated by the fabrication method, and a cell culture system manufactured by the manufacturing method. The porous polymer membrane can be fabricated by spin coating a mixture solution containing a biodegradable elastomeric polymer and a water-soluble moisture absorbent in an optimum ratio while maintaining a high relative humidity. The porous polymer membrane has a uniform thickness and a uniform pore size and is highly elastic. In addition, the thickness and pore size of the porous polymer membrane can be controlled. The porous polymer membrane can induce active cell-cell interaction during cell co-culture due to its high porosity. The porous polymer membrane enables control over cell alignment or array due to its high biocompatibility and elasticity.Type: GrantFiled: October 27, 2020Date of Patent: March 5, 2024Assignee: Korea Institute of Science and TechnologyInventors: Young Mee Jung, Soo Hyun Kim, Justin Jihong Chung, Jin Yoo, Tae Hee Kim
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Publication number: 20230142889Abstract: The present disclosure relates to a biodegradable polymer-gelatin hydrogel composite, a method for preparing the same and a medical implant including the biodegradable polymer-gelatin hydrogel composite. The multi-layered biodegradable polymer-gelatin hydrogel composite of the present disclosure, wherein the biodegradable polymer membrane of a 3D reticular structure and the gelatin hydrogel are stacked, has superior durability and resilience and may exhibit improved elasticity and swellability upon wetting under hydration environment. In addition, it can be shrunk down to 50% of its initial volume upon drying and can maintain elasticity even after the shrinkage. Furthermore, when used in a medical implant, it can protect the joint from the frictional environment in the body, reinforce the muscle torn or ruptured by trauma, relive pain by maintaining space, and induce the improvement of symptoms.Type: ApplicationFiled: November 4, 2022Publication date: May 11, 2023Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Young Mee JUNG, Inchan YOUN
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Patent number: 11607474Abstract: The present invention relates to a method for preparing of a nerve conduit using bio-printing technology and a nerve conduit prepared by the same, and it can easily prepare a nerve conduit by simulating a nerve bundle and nerve tissue, and the like, by three-dimensionally printing bio-ink comprising a neuronal regeneration material on one side of a porous polymer scaffold.Type: GrantFiled: May 15, 2020Date of Patent: March 21, 2023Assignees: Korea University Research and Business Foundation, Korea Institute of Science and TechnologyInventors: Jong Woong Park, Young Mee Jung, Soo Hyun Kim, Justin Jihong Chung
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Publication number: 20210301241Abstract: Provided are a method for fabricating a highly elastic porous polymer membrane, a method for manufacturing a cell culture system using a porous polymer membrane fabricated by the fabrication method, and a cell culture system manufactured by the manufacturing method. The porous polymer membrane can be fabricated by spin coating a mixture solution containing a biodegradable elastomeric polymer and a water-soluble moisture absorbent in an optimum ratio while maintaining a high relative humidity. The porous polymer membrane has a uniform thickness and a uniform pore size and is highly elastic. In addition, the thickness and pore size of the porous polymer membrane can be controlled. The porous polymer membrane can induce active cell-cell interaction during cell co-culture due to its high porosity. The porous polymer membrane enables control over cell alignment or array due to its high biocompatibility and elasticity.Type: ApplicationFiled: October 27, 2020Publication date: September 30, 2021Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Young Mee JUNG, Soo Hyun KIM, Justin Jihong CHUNG, Jin YOO, Tae Hee KIM
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Patent number: 11000989Abstract: A method for preparing a highly elastic biodegradable three-dimensional structure includes (a) mixing poly(lactide-co-?-caprolactone) (PLCL) with at least one biocompatible heat stabilizer that is biocompatible with the PLCL, that is a heat stabilizer for the PLCL, and that is selected from the group consisting of ?-tocopherol, barium-zinc, calcium-zinc, vitamin B, and combinations thereof to provide a solvent-free mixture; and (b) carrying out three-dimensional printing with the solvent-free mixture by heating the mixture at 150-250° C. for 5-20 minutes to provide a heated mixture; and ejecting the heated mixture through a nozzle. The three-dimensional structure maintains mechanical properties even after three-dimensional printing, by adding a biocompatible heat stabilizer to poly(L-lactide-co-?-caprolactone). The three-dimensional structure is useful as a scaffold for tissue engineering.Type: GrantFiled: October 18, 2017Date of Patent: May 11, 2021Assignee: Korea Institute of Science and TechnologyInventors: Young Mee Jung, Soo Hyun Kim, Su Hee Kim
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Publication number: 20200376167Abstract: The present invention relates to a method for preparing of a nerve conduit using bio-printing technology and a nerve conduit prepared by the same, and it can easily prepare a nerve conduit by simulating a nerve bundle and nerve tissue, and the like, by three-dimensionally printing bio-ink comprising a neuronal regeneration material on one side of a porous polymer scaffold.Type: ApplicationFiled: May 15, 2020Publication date: December 3, 2020Applicants: Korea University Research and Business Foundation, Korea Institute of Science and TechnologyInventors: Jong Woong Park, Young Mee Jung, Soo Hyun Kim, Justin Jihong Chung
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Patent number: 10722388Abstract: A solid-state drawing method for preparing a surgical suture or a biodegradable stent having improved flexibility and mechanical strength. The method for preparing a biodegradable stent includes (a) providing a biodegradable filament that comprises a material which is biodegradable; (b) solid-state drawing the biodegradable filament to provide a drawn biodegradable filament; (c) shaping the drawn biodegradable filament to provide a shaped biodegradable filament; and (d) annealing the shaped biodegradable filament to provide the biodegradable stent, wherein the biodegradable filament has a draw ratio that ranges from 1.1 to 5.0; and wherein the draw ratio is calculated by Equation 1 below: Draw ratio=(LSSD/LO)2, where LO is length of the biodegradable filament before the solid-state drawing, and LSSD is the length of the biodegradable filament after the solid-state drawing.Type: GrantFiled: September 27, 2017Date of Patent: July 28, 2020Assignee: Korea Institute of Science and TechnologyInventors: Soo Hyun Kim, Young Mee Jung, Seung Hyuk Im
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Patent number: 10537663Abstract: A method for preparing a decellularized tissue-based hydrogel with maximized ability of preserving various tissue-derived proteins, growth factors and cytokines by using a supercritical fluid-organic solvent system through (a) a step of decellularizing a biological tissue by bringing the same to contact with a supercritical fluid and an organic solvent at the same time; (b) a step of washing the decellularized tissue; (c) a step of preparing a decellularized tissue solution by mixing the washed decellularized tissue with one selected from an enzyme solution, an acidic solution and a mixture thereof; (d) a step of titrating the decellularized tissue solution to pH 5.5-7.8 by treating with a basic solution; and (e) a step of allowing the titrated decellularized tissue solution to stand at 30-40° C. and utilizing the same as a tissue engineering material with improved angiogenesis and tissue regeneration abilities.Type: GrantFiled: November 1, 2017Date of Patent: January 21, 2020Assignee: Korea Institute of Science and TechnologyInventors: Young Mee Jung, Soo Hyun Kim, Yoo Jin Seo
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Patent number: 10434135Abstract: A pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides; injections for preventing or treating arthritis; and a pharmaceutical composition for inducing differentiation of cartilage cells are described herein. Synthetic polypeptides of the present invention consisting of a polypeptide represented by SEQ ID NO: 1 and a polypeptide represented by SEQ ID NO: 2 have activity for recruiting stem cells to an arthritis region, inhibit apoptosis of cartilage cells, and exhibit anti-inflammatory activity and activity for promoting regeneration of cartilage cells. Thus, unlike a conventional arthritis treatment agent, the synthetic polypeptides can improve cartilage damage, can inhibit degenerative changes per se and can, at the same time, exhibit an effect as a stem cell treatment agent, and thereby can be usefully utilized as an arthritis prevention or treatment agent.Type: GrantFiled: March 14, 2016Date of Patent: October 8, 2019Assignees: Samsung Life Public Welfare Foundation, Korea Institute of Science and TechnologyInventors: Sang Jun Kim, Young Mee Jung, Soo Hyun Kim
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Patent number: 10287392Abstract: Disclosed is a method for preparing a poly(L-lactic acid) composite. According to the method, PLLA can be processed without losing its physical properties during thermal processing and can be effectively used to manufacture a final product with improved thermal properties. In addition, the monomer is not thermally decomposed during high-temperature polymerization. Therefore, the poly(L-lactic acid) composite can be prevented from browning. Also disclosed is a poly(L-lactic acid) composite prepared by the method.Type: GrantFiled: September 27, 2017Date of Patent: May 14, 2019Assignee: Korea Institute of Science and TechnologyInventors: Soo Hyun Kim, Young Mee Jung, Seung Hyuk Im
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Publication number: 20190111177Abstract: A method for preparing a highly elastic biodegradable three-dimensional structure and a highly elastic biodegradable three-dimensional structure obtained thereby, particularly, a method for preparing a three-dimensional structure maintains mechanical properties even after three-dimensional printing, by adding a biocompatible heat stabilizer to poly(L-lactide-co-?-caprolactone) and application of the three-dimensional structure to a scaffold for tissue engineering.Type: ApplicationFiled: October 18, 2017Publication date: April 18, 2019Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Young Mee JUNG, Soo Hyun KIM, Su Hee KIM
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Publication number: 20180353648Abstract: A method for preparing a decellularized tissue-based hydrogel with maximized ability of preserving various tissue-derived proteins, growth factors and cytokines by using a supercritical fluid-organic solvent system through (a) a step of decellularizing a biological tissue by bringing the same to contact with a supercritical fluid and an organic solvent at the same time; (b) a step of washing the decellularized tissue; (c) a step of preparing a decellularized tissue solution by mixing the washed decellularized tissue with one selected from an enzyme solution, an acidic solution and a mixture thereof; (d) a step of titrating the decellularized tissue solution to pH 5.5-7.8 by treating with a basic solution; and (e) a step of allowing the titrated decellularized tissue solution to stand at 30-40° C. and utilizing the same as a tissue engineering material with improved angiogenesis and tissue regeneration abilities.Type: ApplicationFiled: November 1, 2017Publication date: December 13, 2018Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Young Mee JUNG, Soo Hyun KIM, Yoo Jin SEO
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Publication number: 20180344489Abstract: A biodegradable stent and a method for preparing the same, which more particularly relate to a technology of preparing a biodegradable stent with improved flexibility and mechanical strength. The method includes a step of solid-state drawing a biodegradable filament and a step of shaping and then annealing the drawn biodegradable filament.Type: ApplicationFiled: September 27, 2017Publication date: December 6, 2018Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Soo Hyun KIM, Young Mee JUNG, Seung Hyuk IM
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Publication number: 20180179331Abstract: Disclosed is a method for preparing a poly(L-lactic acid) composite. According to the method, PLLA can be processed without losing its physical properties during thermal processing and can be effectively used to manufacture a final product with improved thermal properties. In addition, the monomer is not thermally decomposed during high-temperature polymerization. Therefore, the poly(L-lactic acid) composite can be prevented from browning. Also disclosed is a poly(L-lactic acid) composite prepared by the method.Type: ApplicationFiled: September 27, 2017Publication date: June 28, 2018Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Soo Hyun KIM, Young Mee JUNG, Seung Hyuk IM
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Publication number: 20180042984Abstract: The present invention relates to: a pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides; injections for preventing or treating arthritis; and a pharmaceutical composition for inducing differentiation of cartilage cells. Synthetic polypeptides of the present invention consisting of a polypeptide represented by SEQ ID NO: 1 and a polypeptide represented by SEQ ID NO: 2 have activity for recruiting stem cells to an arthritis region, inhibit apoptosis of cartilage cells, and exhibit anti-inflammatory activity and activity for promoting regeneration of cartilage cells. Thus, unlike a conventional arthritis treatment agent, the synthetic polypeptides can improve cartilage damage, can inhibit degenerative changes per se and can, at the same time, exhibit an effect as a stem cell treatment agent, and thereby can be usefully utilized as an arthritis prevention or treatment agent.Type: ApplicationFiled: March 14, 2016Publication date: February 15, 2018Inventors: Sang Jun Kim, Young Mee Jung, Soo Hyun Kim
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Patent number: 9644183Abstract: A method for differentiating stem cells into vascular cells, including adhering the stem cells to a culture plate with a surface having a hydrophobic property or on which a growth factor is immobilized, and culturing the cells. The cultured stem cells later detach from the culture plate as their density increases to form a three-dimensional cell cluster and differentiate into vascular cells. The cell cluster can be used as a cell therapy agent for angiogenesis.Type: GrantFiled: March 24, 2010Date of Patent: May 9, 2017Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Sang-Heon Kim, Soo Hyun Kim, In Su Park, Young Mee Jung
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Patent number: 9096709Abstract: Disclosed are a polylactide stereocomplex with improved thermal stability and thus improved processability and a method for preparing the same. In order to confer flexibility to polymer chains, D-type polylactide polymer containing a small amount of caprolactone (poly D-lactide-caprolactone copolymer) is synthesized and it is uniformly mixed with L-type single-phase polylactide to prepare a flexible polylactide stereocomplex. Since the polylactide stereocomplex having flexible polymer chains has superior heat resistance and mechanical stability and experiences little decrease of the degree of stereocomplex formation even after thermal processing, the polylactide stereocomplex having improved thermal stability can be advantageously used for engineering plastics requiring high strength and good thermal stability, alternative materials for general-use plastics, high-performance medical materials, or the like because of its remarkably improved processability.Type: GrantFiled: October 21, 2014Date of Patent: August 4, 2015Assignees: Hyundai Motor Company, Korea Institute of Science and TechnologyInventors: Chae Hwan Hong, Do Suck Han, Soo Hyun Kim, Young Mee Jung
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Publication number: 20150057385Abstract: Disclosed are a polylactide stereocomplex with improved thermal stability and thus improved processability and a method for preparing the same. In order to confer flexibility to polymer chains, D-type polylactide polymer containing a small amount of caprolactone (poly D-lactide-caprolactone copolymer) is synthesized and it is uniformly mixed with L-type single-phase polylactide to prepare a flexible polylactide stereocomplex. Since the polylactide stereocomplex having flexible polymer chains has superior heat resistance and mechanical stability and experiences little decrease of the degree of stereocomplex formation even after thermal processing, the polylactide stereocomplex having improved thermal stability can be advantageously used for engineering plastics requiring high strength and good thermal stability, alternative materials for general-use plastics, high-performance medical materials, or the like because of its remarkably improved processability.Type: ApplicationFiled: October 21, 2014Publication date: February 26, 2015Inventors: Chae Hwan Hong, Do Suck Han, Soo Hyun Kim, Young Mee Jung
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Patent number: 8889797Abstract: Disclosed are a polylactide stereocomplex with improved thermal stability and thus improved processability and a method for preparing the same. In order to confer flexibility to polymer chains, D-type polylactide polymer containing a small amount of caprolactone (poly D-lactide-caprolactone copolymer) is synthesized and it is uniformly mixed with L-type single-phase polylactide to prepare a flexible polylactide stereocomplex. Since the polylactide stereocomplex having flexible polymer chains has superior heat resistance and mechanical stability and experiences little decrease of the degree of stereocomplex formation even after thermal processing, the polylactide stereocomplex having improved thermal stability can be advantageously used for engineering plastics requiring high strength and good thermal stability, alternative materials for general-use plastics, high-performance medical materials, or the like because of its remarkably improved processability.Type: GrantFiled: October 31, 2011Date of Patent: November 18, 2014Assignees: Hyundai Motor Company, Korea Institute of Science and TechnologyInventors: Chae Hwan Hong, Do Suck Han, Soo Hyun Kim, Young Mee Jung
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Patent number: 8716398Abstract: The present invention relates to methods for preparing biodegradable polymer stereocomplexes using a supercritical fluid-organic solvent system and polymer stereocomplexes prepared by such methods. The method of the present invention involves introducing two types of homopolymers having different stereostructures and a small amount of organic solvent into a reactor, adding a supercritical fluid thereto, followed by applying a specific temperature and pressure to form a polymer stereocomplex having a crystalline structure. According to the method of the present invention, biodegradable polymer stereocomplexes in the form of powder or porous foam having excellent thermal and mechanical stabilities can be prepared in a simple, economical and environmentally-friendly manner in a single process.Type: GrantFiled: November 17, 2010Date of Patent: May 6, 2014Assignee: Korea Institute of Science and TechnologyInventors: Soo Hyun Kim, Young Mee Jung, Sang-Heon Kim, Purnama Purba