Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Abstract: A method of reinforcement learning of a neural network device for generating a verification vector for verifying a circuit design comprising a circuit block includes inputting a test vector to the circuit block, generating one or more rewards based on a coverage corresponding to the test vector, the coverage being determined based on a state transition of the circuit block based on the test vector, and applying the one or more rewards to a reinforcement learning.

Abstract: An orthodontic wire bending device includes a providing part, a bending unit and a cutting part. The providing part is configured to provide a wire. The bending unit is disposed at a front side of the providing part, and includes a fixing part and a bending part. The fixing part is configured to fix the wire. The bending part is configured to bend the wire fixed by the fixing part. The cutting part is configured to cut the wire bent by the bending part. The bending part includes a bending module, and the bending module is rotated along a circumferential direction or moves along a direction to make contact with at least one side of the wire for bending the wire.

Abstract: A memory controller includes a plurality of processors, a memory device and a memory manager. The memory device includes a plurality of segments, which are divided into a plurality of segment groups, to which group identifiers are respectively assigned. The memory manager is configured to map a first buffer identifier to a first group identifier from among the group identifiers, select one or more segments only from a first segment group, to which the first group identifier is assigned among the plurality of segment groups, map the first buffer identifier to the one or more segments, and allocate, to a first processor from among the plurality of processors, the first buffer identifier and the one or more segments.

Abstract: The present disclosure relates to a heteroaryl derivative and uses thereof. The heteroaryl derivative of the present disclosure exhibits excellent inhibitory activity against EGFR and/or HER2, and thus may be usefully employed as a therapeutic agent for EGFR- and/or HER2-related diseases.

Abstract: The present invention relates to a heteroaryl derivative and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient, and a compound according to an aspect of the present invention, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof suppresses kinases, particularly, a TTK kinase, and thus can remarkably suppress the proliferation of cancer cells, and accordingly, can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer.

Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell limes, and thus can be usefully used in the treatment of lung cancer.

Abstract: The present discloses a waste screening apparatus comprising: a main body; a waste screener vertically and tiltedly disposed in the main body to screen wastes in the input water and to allow waste-removed water to be discharged through water discharge holes defined in both side faces of the main body respectively, wherein the waste screener vertically circulates in a conveyor manner, wherein the input water is input to a front, rear and bottom of the waste screener; wherein the main body includes: both side walls having the water discharge holes defined therein respectively to allow waste-removed water to be discharged out from the waste screener therethrough; and a rear blocking wall disposed at a rear of the waste screener to be spaced from the waste screener, wherein the input water passes through front and rear portions of the waste screener with wastes being removed from the input water, and, then, is discharged out through the water discharge holes defined in the both side walls respectively.

Abstract: The present discloses a waste screening apparatus comprising: a main body; a waste screener vertically and tiltedly disposed in the main body to screen wastes in the input water and to allow waste-removed water to be discharged through water discharge holes defined in both side faces of the main body respectively, wherein the waste screener vertically circulates in a conveyor manner, wherein the input water is input to a front, rear and bottom of the waste screener; wherein the main body includes: both side walls having the water discharge holes defined therein respectively to allow waste-removed water to be discharged out from the waste screener therethrough; and a rear blocking wall disposed at a rear of the waste screener to be spaced from the waste screener, wherein the input water passes through front and rear portions of the waste screener with wastes being removed from the input water, and, then, is discharged out through the water discharge holes defined in the both side walls respectively.

Abstract: Disclosed is a method for identifying the species of diatoms found in the coastal area of Korea, a polynucleotide probe, a DNA chip and a kit used for identifying the diatom species. The method includes obtaining a PCR product by performing a PCR reaction using the DNA extracted from diatoms, binding the PCR product respectively to a probe which is the same as or complementary to one or more of the nucleotide sequences selected from SEQ. ID. NOs: 3˜51, and identifying the species of a given diatom based on the result of the above binding. More importantly, the present invention enables to identify a given diatom species by analyzing the genotypes of various diatom species found in the coastal area of Korea based on their SNPs in a convenient, fast and accurate way.

Abstract: A heat treatment apparatus for manufacturing a liquid crystal display panel through an in-situ process includes a body and a hardening unit, an annealing unit, and a transferring unit disposed on the body. The hardening unit heats a sealing member within a liquid crystal display panel to harden the sealing member. The annealing unit anneals liquid crystal within the liquid crystal display panel sealed by the sealing member. The transferring unit transfers the liquid crystal display panel between the hardening unit and the annealing unit. Therefore, the sealing member may be hardened and the liquid crystal may be sealed through an in-situ process to enhance productivity.

Abstract: An inkjet printing system includes; a stage configured for mounting a substrate thereon, an inkjet head which drips an ink droplet on the substrate, a conveying device which moves the inkjet head, and a measuring device which measures a height of the ink droplet on the substrate.

Abstract: A license-management system and method is provided. A method of issuing a proxy certificate includes transmitting a proxy-certificate-issuance-request message to a license server in order for the local license manager to acquire an authority to issue a license by a local license manager; enabling the license server to verify the proxy-certificate-issuance-request message; if the proxy-certificate-issuance-request message is valid, transmitting a proxy certificate to the local license manager by the license server, the proxy certificate including information regarding the authority to issue a license; and verifying the proxy certificate by the local license manager.

Abstract: An inkjet printing system includes; a stage configured for mounting a substrate thereon, an inkjet head which drips an ink droplet on the substrate, a conveying device which moves the inkjet head, and a measuring device which measures a height of the ink droplet on the substrate.

Abstract: A heat treatment apparatus for manufacturing a liquid crystal display panel through an in-situ process includes a body and a hardening unit, an annealing unit, and a transferring unit disposed on the body. The hardening unit heats a sealing member within a liquid crystal display panel to harden the sealing member. The annealing unit anneals liquid crystal within the liquid crystal display panel sealed by the sealing member. The transferring unit transfers the liquid crystal display panel between the hardening unit and the annealing unit. Therefore, the sealing member may be hardened and the liquid crystal may be sealed through an in-situ process to enhance productivity.

Abstract: A heat treatment apparatus for manufacturing a liquid crystal display panel through an in-situ process includes a body and a hardening unit, an annealing unit, and a transferring unit disposed on the body. The hardening unit heats a sealing member within a liquid crystal display panel to harden the sealing member. The annealing unit anneals liquid crystal within the liquid crystal display panel sealed by the sealing member. The transferring unit transfers the liquid crystal display panel between the hardening unit and the annealing unit. Therefore, the sealing member may be hardened and the liquid crystal may be sealed through an in-situ process to enhance productivity.

Abstract: A license-management system and method is provided. A method of issuing a proxy certificate includes transmitting a proxy-certificate-issuance-request message to a license server in order for the local license manager to acquire an authority to issue a license by a local license manager; enabling the license server to verify the proxy-certificate-issuance-request message; if the proxy-certificate-issuance-request message is valid, transmitting a proxy certificate to the local license manager by the license server, the proxy certificate including information regarding the authority to issue a license; and verifying the proxy certificate by the local license manager.