Patents by Inventor Youqing Shen

Youqing Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200215197
    Abstract: This present invention relates to a polymer of ?-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal. The polymer comprises a ?-glutamyl transpeptidase-responsive element represented by Formula (I). When the polymer is used as drug carrier for anticancer drug, it can have a long circulation time in the blood, and can realize a charge reversal from negatively charged or the neutral to positively charged around the tumor blood vessel region, so that the positively charged polymer effectively penetrates deep into the tumor tissue, fast entering into the tumor cells, and greatly improves the therapeutic effect of the drug on the tumor. This overcomes the problems of slow diffusion of traditional polymer drug carriers in tumors and weak interaction with tumor cells, and has great significance in the field of anticancer treatment in the medical field.
    Type: Application
    Filed: September 21, 2018
    Publication date: July 9, 2020
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Youqing SHEN, Quan ZHOU, Changhuo XU, Jiajia XIANG
  • Patent number: 10640592
    Abstract: Disclosed are the cation polymers capable of removing their positive charges in oxidative conditions, preparation methods, and applications as gene delivery carriers. The oxidation-responsive unit is the p-(boronic acid or ester)benzylammonium, which upon oxidation eliminates p-hydroxymethlphenol and thus converts in a tertiary amine. Compared with the prior art, different from a common quaternary amination carrier, the synthesized charge reversal type gene delivery carrier for oxidative response of the present invention has a large quantity of positive charges and can well coat a DNA, but the positive charges can be removed under the condition of intracellular oxidation when the charge reversal type gene delivery carrier enters a cell, a charge reverse is triggered, the positive charges turn to negative charges, and the DNA is quickly released for transfection. The carrier is efficient, low in toxicity, and good in application prospect.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: May 5, 2020
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Youqing Shen, Xin Liu, Jianbin Tang, Xiangrui Liu
  • Publication number: 20190336604
    Abstract: Disclosed are a self-assembled drug-loading system containing a hydrophilic phototherapeutic drug and a hydrophobic chemotherapeutic drug, a preparation method therefor and the use thereof for preparing an anti-tumor drug. The self-assembled drug-loading system is a water-soluble complex or water-dispersible nanoparticles formed by means of ?-? interaction or hydrophobic interaction between the phototherapeutic drug and the chemotherapeutic drug, wherein the molar ratio of the phototherapeutic drug to the chemotherapeutic drug is 2:1 to 1:10.
    Type: Application
    Filed: December 14, 2017
    Publication date: November 7, 2019
    Inventors: Youqing SHEN, Shiqi HU
  • Publication number: 20180312617
    Abstract: Disclosed are the cation polymers capable of removing their positive charges in oxidative conditions, preparation methods, and applications as gene delivery carriers. The oxidation-responsive unit is the p-(boronic acid or ester)benzylammonium, which upon oxidation eliminates p-hydroxymethlphenol and thus converts in a tertiary amine. Compared with the prior art, different from a common quaternary amination carrier, the synthesized charge reversal type gene delivery carrier for oxidative response of the present invention has a large quantity of positive charges and can well coat a DNA, but the positive charges can be removed under the condition of intracellular oxidation when the charge reversal type gene delivery carrier enters a cell, a charge reverse is triggered, the positive charges turn to negative charges, and the DNA is quickly released for transfection. The carrier is efficient, low in toxicity, and good in application prospect.
    Type: Application
    Filed: October 13, 2015
    Publication date: November 1, 2018
    Inventors: YOUQING SHEN, XIN LIU, JIANBIN TANG, XIANGRUI LIU
  • Patent number: 10072125
    Abstract: The present invention discloses thiourea-containing dendrimers and thiourea-containing hyperbranched polymers, and respectively a preparation method for the thiourea-containing dendrimer and a preparation method for the thiourea-containing hyperbranched polymer, and a thiourea-containing dendrimer and a thiourea-containing hyperbranched polymer having increased water solubility prepared by using the thiourea-containing dendrimer and the thiourea-containing hyperbranched polymer as raw materials. Finally, disclosed are applications of the thiourea-containing dendrimers and the thiourea-containing hyperbranched polymers in the preparation of antitumor and antimicrobial drugs. The thiourea-containing dendrimer and the thiourea-containing hyperbranched polymer have a significant growth inhibitive effect on solid tumors and low toxicity to normal tissues, and thus can be used for preparing drugs for treating malignant tumors.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: September 11, 2018
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Youqing Shen, Shiqun Shao, Jianbin Tang, Xiangrui Liu
  • Publication number: 20170306101
    Abstract: The present invention discloses thiourea-containing dendrimers and thiourea-containing hyperbranched polymers, and respectively a preparation method for the thiourea-containing dendrimer and a preparation method for the thiourea-containing hyperbranched polymer, and a thiourea-containing dendrimer and a thiourea-containing hyperbranched polymer having increased water solubility prepared by using the thiourea-containing dendrimer and the thiourea-containing hyperbranched polymer as raw materials. Finally, disclosed are applications of the thiourea-containing dendrimers and the thiourea-containing hyperbranched polymers in the preparation of antitumor and antimicrobial drugs. The thiourea-containing dendrimer and the thiourea-containing hyperbranched polymer have a significant growth inhibitive effect on solid tumors and low toxicity to normal tissues, and thus can be used for preparing drugs for treating malignant tumors.
    Type: Application
    Filed: January 30, 2015
    Publication date: October 26, 2017
    Inventors: YOUQING SHEN, SHIQUN SHAO, JIANBIN TANG, XIANGRUI LIU
  • Patent number: 9145472
    Abstract: Described are charge reversible polymers, peptides and their resulting colloidal particles, comprising polymers and peptides having primary and secondary amines that are protected as easily hydrolysable amides. The amides are charge-reversible such that at neutral pH they are negatively charged but become positively charged at pH less than 6 and thus are relatively stable at neutral pH but quickly hydrolyze at pH below 6. Incorporating a drug in a micelle or a polymer comprised of the charge-reversible polymers or peptides provides a drug carrier for delivering the drug preferentially to the solid tumor or other targeted cells.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: September 29, 2015
    Assignee: Wyoming Research Products Center
    Inventors: Youqing Shen, Peisheng Xu
  • Publication number: 20150250899
    Abstract: A nano-sized hydrogel is made of a water-soluble chain containing carboxylic acid moieties and polyethylene side chains. Such a nanogel is applicable as a cancer-drug delivery agent or an imagining agent, where either a cancer drug, such as cisplatin, or an imaging agent, such as Gd3+. The complexation of the cancer drug or the imaging agent with the carboxyl moieties leads to the hydrogel formation.
    Type: Application
    Filed: May 26, 2015
    Publication date: September 10, 2015
    Inventors: Maciej Radosz, Youqing Shen, Edward Alva VanKirk, William James Murdoch
  • Publication number: 20150045274
    Abstract: The present invention relates to the field of perfumery. More particularly, it concerns compounds comprising at least one ?-thio carbonyl or nitrile moiety capable of liberating an active molecule selected from an ?,?-unsaturated ketone, aldehyde or nitrile. The present invention concerns also the use of said compounds in perfumery as well as the perfuming compositions or perfumed articles comprising the invention's compounds. (I) wherein: a) m represents an integer from 1 to 6; b) Pro represents a hydrogen atom or a group susceptible of generating an odoriferous ?,?-unsaturated ketone, aldehyde or nitrile and is represented by the formulae (II) or (II?) in which the wavy line indicates the location of the bond between said Pro and the sulfur atom S; and at least one of the Pro groups is of the formula (II) or (II?).
    Type: Application
    Filed: March 19, 2013
    Publication date: February 12, 2015
    Inventors: Peter Fankhauser, Andreas Herrmann, Umberto Maddalena, Alain Trachsel, Youqing Shen
  • Patent number: 8945629
    Abstract: The invention is a nanoparticle that contains an anticancer drug that is released in cancer cells when administered to a subject. The nanoparticles have a core including the anticancer drug and polymer chains that are soluble at the pH of the cancer cell. The core is surrounded by a layer of polymer chains that are insoluble at the pH of healthy tissue but soluble at the pH of the cancer interstitium. An outside layer is made of water-soluble polymer chains to shield the nanoparticle from RES recognition and give the nanoparticle a long circulation time in the bloodstream of the subject. The outside layer may also include folic acid moieties that bind folic acid receptors on the surface of the cancer cell.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: February 3, 2015
    Assignee: University of Wyoming
    Inventors: Maciej Radosz, Peisheng Xu, Youqing Shen
  • Patent number: 8901031
    Abstract: Novel brominated poly(2,6-diphenyl-1,4-phenylene oxide) compounds are synthesized and found to have improved carbon dioxide separation properties, including improved carbon dioxide permeability and improved carbon dioxide/nitrogen selectivity.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: December 2, 2014
    Assignee: University of Wyoming
    Inventors: Maciej Radosz, Youqing Shen
  • Patent number: 8845988
    Abstract: A low-pressure multifunctional filter separates CO2 and other air pollutants from flue, coal, natural and other gas mixtures. The separation agent is a solid carbon-rich sorbent, such as coke, charcoal, coal or activated carbon, that captures CO2 and other air pollutants at lower temperatures and liberates them at higher temperatures. The sorbent is regenerated by heating with direct steam, hot CO2 or other source of thermal energy. The recovered CO2-rich product can be used for enhanced oil recovery, enhanced methane recovery, and subsequent storage in depleted oil and gas reservoirs.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: September 30, 2014
    Assignee: Wyoming Research Products Center
    Inventors: Maciej Radosz, Youqing Shen
  • Patent number: 8703902
    Abstract: Polymerizable ionic liquid monomers and their corresponding polymers (poly(ionic liquid)s) are created and found to exhibit high absorption of radio frequency electromagnetic radiation, particularly in the microwave and radar bands. These materials are useful for coating objects to make them less reflective of radio frequency radiation and for making objects that absorb radio frequency radiation and are of minimal reflectivity to radio frequency radiation. Free-radical and condensation polymerization approaches are used in the preparation of the poly(ionic liquids).
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: April 22, 2014
    Assignee: University of Wyoming
    Inventors: Maciej Radosz, Youqing Shen, Huadong Tang
  • Publication number: 20130225401
    Abstract: Polymerizable ionic liquid monomers and their corresponding polymers (poly(ionic liquid)s) are created and found to exhibit high CO2 sorption. The poly(ionic liquid)s have enhanced and reproducible CO2 sorption capacities and sorption/desorption rates relative to room-temperature ionic liquids. Furthermore, these materials exhibit selectivity relative to other gases such as nitrogen, methane, and oxygen. They are useful as efficient separation agents, such sorbents and membranes. Novel free-radical and condensation polymerization approaches are used in the preparation of the poly(ionic liquids).
    Type: Application
    Filed: September 21, 2012
    Publication date: August 29, 2013
    Applicant: THE UNIVERSITY OF WYOMING
    Inventors: Youqing Shen, Maciej Radosz
  • Patent number: 8449652
    Abstract: Polymerizable ionic liquid monomers and their corresponding polymers (poly(ionic liquid)s) are created and found to exhibit high CO2 sorption. The poly(ionic liquid)s have enhanced and reproducible CO2 sorption capacities and sorption/desorption rates relative to room-temperature ionic liquids. Furthermore, these materials exhibit selectivity relative to other gases such as nitrogen, methane, and oxygen. They are useful as efficient separation agents, such sorbents and membranes. Novel radical and condensation polymerization approaches are used in the preparation of the poly(ionic liquids).
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: May 28, 2013
    Assignee: University of Wyoming
    Inventors: Maciej Radosz, Youqing Shen
  • Publication number: 20120177592
    Abstract: A method of developing degradable linear poly(ethylene glycol) PEG (DPEG) with multiple functioning capacities, which can be used as drug carriers for cancer cell delivery. A DPEG may be effective in targeting cancerous tumors through an enhanced permeation and retention effect (EPR). The DPEG will then degrade in the acidic extracellular fluid of solid tumors leading to fast cellular internalizations, finally degrading in the lysosome for efficient renal clearance. These may be used in conjunction with drugs and/or targeting groups. Furthermore, DPEGs are thermoresponsive, on an as needed basis, making them useful for in vivo application.
    Type: Application
    Filed: May 30, 2008
    Publication date: July 12, 2012
    Applicant: UNIVERSITY OF WYOMING
    Inventors: Maciej Radosz, Youqing Shen
  • Publication number: 20120003177
    Abstract: Curcumin, a polyphenol extracted from the rhizome turmeric, has been polymerized to produce a polymer material having a backbone of one or more repeating structural units, at least one of which comprises a curcumin monomer residue. These curcumin-containing polymers have a wide range of pharmacological activities, including, among others antitumor, antioxidant, antiinflammatory, antithrombotic and antibacterial activities. Certain species of these polymers have exhibited remarkable antitumor activity. Water-soluble curcumin derivatives and their use as prodrugs and prodrug carriers are also disclosed.
    Type: Application
    Filed: September 17, 2009
    Publication date: January 5, 2012
    Inventors: Youqing Shen, Huadong Tang, Edward Van Kirk, William Murdoch, Maciej Radosz
  • Publication number: 20110244046
    Abstract: Described are charge reversible polymers, peptides and their resulting colloidal particles, comprising polymers and peptides having primary and secondary amines that are protected as easily hydrolysable amides. The amides are charge-reversible such that at neutral pH they are negatively charged but become positively charged at pH less than 6 and thus are relatively stable at neutral pH but quickly hydrolyze at pH below 6. Incorporating a drug in a micelle or a polymer comprised of the charge-reversible polymers or peptides provides a drug carrier for delivering the drug preferentially to the solid tumor or other targeted cells.
    Type: Application
    Filed: February 23, 2011
    Publication date: October 6, 2011
    Applicant: WYOMING RESEARCH PRODUCTS CENTER
    Inventors: Youqing Shen, Peisheng Xu
  • Patent number: 7994087
    Abstract: A class of catalysts with unusually high activity for polymerizing vinyl monomers such as acrylates, methacrylates and styrene is described. The catalysts consists of a metal halide such as CuBr and FeBr2 ligated with multidentate amine-based ligands, for example N,N,N?,N?-tetra[(2-pyridal)methyl]ethylenediamine, and additives. The additives, which are tertiary amine compounds, can greatly increase the catalytic activity. The complex is capable of catalyzing a living polymerization reaction at a concentration of the complex below about 0.1 mol %.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: August 9, 2011
    Assignee: Wyoming Research Products Center
    Inventors: Maciej Radosz, Youqing Shen, Huadong Tang
  • Publication number: 20100270695
    Abstract: Disclosed is a process for forming nanoparticles by the micellization of blocky copolymers in either subcritical or supercritical solvents and antisolvents. The nanoparticles are suited for use as delivery vehicles for drugs and genes.
    Type: Application
    Filed: September 5, 2007
    Publication date: October 28, 2010
    Inventors: Maciej Radosz, Youqing Shen