Patents by Inventor Youssef Anouar

Youssef Anouar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PREVENTING OR TREATING CANCER RESISTANCE TO EGFR INHIBITION
    Publication number: 20200237736
    Abstract: The invention relates to methods for preventing or treating resistance to EGFR inhibitors in cancer patients. More particularly, after performing a screen for small molecules potentially capable of countering cancer resistance to EGFR TKI, inventors identified the multikinase inhibitor sorafenib, which has the property, in combination with EGFR TKI, to prevent the enrichment of tumor cells containing mutations responsible for NSCLC resistance to first and third generation EGFR TKI. These data indicate that this multikinase inhibitor can prevent resistance to several generations of EGFR TKI. These in vitro data were confirmed in an in vivo xenograft mouse model of NSCLC. Finally these data were reproduced in cancer cells using SC-1, a sorafenib analogue.
    Type: Application
    Filed: June 22, 2018
    Publication date: July 30, 2020
    Inventors: Luca GRUMOLATO, Alexis GUERNET, Stuart AARONSON, Youssef ANOUAR
  • Methods and Pharmaceutical Compositions Using Orexins (OXA, OXB) for the Treatment of Prostate Cancers
    Publication number: 20170319661
    Abstract: The present disclosure relates to methods and pharmaceutical compositions for the treatment of prostate cancers. In particular, the present invention relates to an OX1R agonist for use in the treatment of prostate cancer in a subject in need thereof.
    Type: Application
    Filed: December 3, 2014
    Publication date: November 9, 2017
    Inventors: Nicolas Chartrel, Youssef Anouar, Lydie Jeandel, David Alexandre, Jerome Leprince, Alain Couvineau, Thierry Voisin