Patents by Inventor Youssef Laafiret Bennani

Youssef Laafiret Bennani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapy to treat mycobacterium diseases
    Patent number: 9937192
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 10, 2018
    Assignee: SPERO TRINEM, INC.
    Inventors: Christopher Phillip Locher, Youssef Laafiret Bennani, Anne-Laure Grillot, Hardwin O'Dowd, Emanuele Perola, Arnaud Le Tiran, Paul S. Charifson
  • COMBINATION THERAPY TO TREAT MYCOBACTERIUM DISEASES
    Publication number: 20170128471
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
    Type: Application
    Filed: January 19, 2017
    Publication date: May 11, 2017
    Inventors: Christopher Phillip Locher, Youssef Laafiret Bennani, Anne-Laure Grillot, Hardwin O'Dowd, Emanuele Perola, Arnaud Le Tiran, Paul S. Charifson
  • Combination therapy to treat diseases
    Patent number: 9572809
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: February 21, 2017
    Assignee: SPERO TRINEM, INC.
    Inventors: Christopher Phillip Locher, Youssef Laafiret Bennani, Anne-Laure Grillot, Hardwin O'Dowd, Emanuele Perola, Arnaud Le Tiran, Paul S. Charifson
  • Phosphate esters of gyrase and topoisomerase inhibitors
    Patent number: 9125922
    Abstract: The present invention relates to phosphate esters of compounds that inhibit bacterial gyrase and/or Topoisomerase IV and pharmaceutical compositions thereof. These phosphate esters are useful for treating bacterial infections.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: September 8, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Youssef Laafiret Bennani, Paul S. Charifson, Anne-Laure Grillot, Arnaud Le Tiran, Hardwin O'Dowd
  • Gyrase and topoisomerase IV inhibitors
    Patent number: 8969359
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: March 3, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Arnaud Le Tiran, Anne-Laure Grillot, Paul S. Charifson, Youssef Laafiret Bennani, Hardwin O'Dowd, Emanuele Perola
  • MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20140107049
    Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. The invention also provides processes for making the compounds of the invention. The compounds of the present invention are represented by the following structure of Formula A: wherein the variables are as described herein.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 17, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Youssef Laafiret Bennani, Bingcan Liu
  • COMBINATION THERAPY TO TREAT MYCOBACTERIUM DISEASES
    Publication number: 20140045791
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
    Type: Application
    Filed: July 15, 2013
    Publication date: February 13, 2014
    Inventors: Christopher Phillip Locher, Youssef Laafiret Bennani, Ann-Laure Grillot, Hardwin O'Dowd, Emanuele Perola, Arnaud Le Tiran
  • GYRASE AND TOPOISOMERASE IV INHIBITORS
    Publication number: 20130289002
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.
    Type: Application
    Filed: June 3, 2013
    Publication date: October 31, 2013
    Inventors: Arnaud Le Tiran, Anne-Laure Grillot, Paul S. Charifson, Youssef Laafiret Bennani, Hardwin O'Dowd, Emanuele Perola
  • MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20130261077
    Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.
    Type: Application
    Filed: March 6, 2013
    Publication date: October 3, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Youssef Laafiret Bennani, Caroline Cadilhac, Sanjoy Kumar Das, Evelyne Dietrich, Michel Gallant, Bingcan Liu, Oswy Z. Pereira, Yeeman K. Ramtohul, T. Jagadeeswar Reddy, Louis Vaillancourt, Constantin Yannopoulos, Frederic Vallee
  • PHOSPHATE ESTERS OF GYRASE AND TOPOISOMERASE INHIBITORS
    Publication number: 20130157979
    Abstract: The present invention relates to phosphate esters of compounds that inhibit bacterial gyrase and/or Topoisomerase IV and pharmaceutical compositions thereof. These phosphate esters are useful for treating bacterial infections.
    Type: Application
    Filed: June 20, 2012
    Publication date: June 20, 2013
    Inventors: Youssef Laafiret Bennani, Paul S. Charifson, Anne-Laure Grillot, Arnaud Le Tiran, Hardwin O'Dowd