Abstract: The present disclosure belongs to the field of materials with metal structures, and specifically relates to a preparation method for a nano-oxide dispersion strengthened steel. The method includes mixing a ferrochromium alloy, a ferrotungsten alloy, a ferroalloy containing a rare earth element, an oxygen source and a reduced iron powder to obtain a mixture; wrapping the mixture in a steel strip, and conducting drawing reducing to obtain a flux-cored wire; and conducting arc additive manufacturing on the flux-cored wire on a substrate, and then conducting heat treatment to obtain the nano-oxide particle dispersion strengthened steel.

Abstract: The present invention is directed to the identification, characterization and three-dimensional structure of a novel ligand binding site of KSP. Binding of ligands to the novel binding site result in a conformational change in the three-dimensional structure of the protein and a modulation of the activity of KSP. This conformational change in turn results in the formation of a novel binding pocket in the KSP protein, which comprises the novel binding site of the instant invention.