Patents by Inventor Yow-Fu Tsai

Yow-Fu Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-selective sialyl donor and its uses for preparation of sialosides
    Patent number: 10435425
    Abstract: Disclosed herein a sialyl donor and its use for the synthesis of gangliosides. The sialyl donor has the structure of, wherein, R1 and R2 are independently benzoyl, toluenesulfonyl, pivaloyl or acetyl optionally substituted with a halogen; and R3 is acetyl or —(O)CCH2OH. In one preferred embodiment, in the sialyl donor of formula (I), R is acetyl. Also disclosed herein is a method of synthesizing a sialoside. The method comprises steps of: coupling the sialyl donor of formula (I) with a glycosyl acceptor having a primary hydroxyl group in the presence of N-iodosuccinimide (NIS) and trifluoromethanesulfonic acid (TfOH) under suitable conditions; and isolating the sialoside, which has an ?-glycosidic linkage. According to preferred embodiments, the coupling is conducted in a solvent selected from the group consisting of, CH3CN, CH3Cl, and CH2Cl2 at a temperature between ?20° C. to ?60° C.
    Type: Grant
    Filed: July 14, 2018
    Date of Patent: October 8, 2019
    Assignee: Chung Yuan Christian University
    Inventors: Yow-Fu Tsai, Yu-Fa Wu
  • Immuno-modulating antitumor activities of (Reishi) polysaccharides
    Patent number: 7560114
    Abstract: The present invention provides methods of modulating an immune response in an organism by administering medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: July 14, 2009
    Inventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai
  • IMMUNO-MODULATING ANTITUMOR ACTIVITIES OF GANODERMA LUCIDUM (REISHI) POLYSACCHARIDES
    Publication number: 20080267991
    Abstract: The present invention provides methods of modulating an immune response in an organism by administering medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum.
    Type: Application
    Filed: December 6, 2007
    Publication date: October 30, 2008
    Inventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai
  • Immuno-modulating antitumor activities of ganoderma lucidum (reishi) polysaccharides
    Patent number: 7323176
    Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: January 29, 2008
    Assignee: Academia Sinica
    Inventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai
  • IMMUNO-MODULATING ANTITUMOR ACTIVITIES OF GANODERMA LUCIDUM (REISHI) POLYSACCHARIDES
    Publication number: 20070104729
    Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.
    Type: Application
    Filed: October 26, 2006
    Publication date: May 10, 2007
    Applicant: ACADEMIA SINICA
    Inventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai
  • Immuno-modulating antitumor activities of (Reishi) polysaccharides
    Patent number: 7135183
    Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: November 14, 2006
    Assignee: Academia Sinica
    Inventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai