Abstract: The present invention relates to a method for producing recombinant human prethrombin-2 protein and having human ?-thrombin activity by the plant-based expression systems.

Abstract: A laser inspection system is provided. A laser source emits a laser with a first spectrum and the laser is transmitted by a first optical fiber. A gain optical fiber doped with special ions is connected to the first optical fiber, and a light detector is provided around the gain optical fiber. When the laser with the first spectrum passes through the gain optical fiber, the gain optical fiber absorbs part of the energy level of the laser with the first spectrum, so that the laser with the first spectrum is converted to generate light with a second spectrum based on the frequency conversion phenomenon. The light detector detects the intensity of the light with the second spectrum, so that the power of the laser source can be obtained.

Abstract: An optical fiber module is provided and includes an optical fiber structure, a light-absorbing area and a photoelectric sensor in a housing. The optical fiber structure collectively arranges a plurality of first optical fibers to form at least one optical fiber bundle with a tapered end, and a second optical fiber is connected to the tapered end of the optical fiber bundle to converge the optical fiber bundle to the second optical fiber. The light-absorbing area corresponds to an end of the second optical fiber, such that the light-absorbing area absorbs scattering signals escaped and scattered when signals are transmitted from the plurality of first optical fibers to the second optical fiber. The photoelectric sensor is arranged corresponding to the plurality of first optical fibers to receive target signals escaped and refracted when the signals are transmitted from the second optical fiber to the plurality of first optical fibers.

Abstract: A soldering process method includes steps of: establishing a material component database; establishing a working parameter database; analyzing material and component characteristics required for a new soldering process; comparing the characteristics with information in the material component database; selecting operating parameters corresponding to the material and component characteristics similar to those required for the new soldering process; performing the soldering process using the operating parameters corresponding to the material and component characteristics similar to those required for the new soldering process; measuring and recording the soldering process execution information and the final product information; determining whether the final product of the solder process meets the quality control requirements; using the machine learning method to fit the soldering process execution information and the final product information of the solder process to get the operating parameters for the next sol

Abstract: An image positioning system based on upsampling and a method thereof are provided. The image positioning method based on upsampling is to fetch a region image covering a target from a wide region image, determine a rough position of the target, execute an upsampling process on the region image based on neural network data model for obtaining a super-resolution region image, map the rough position onto the super-resolution region image, and analyze the super-resolution region image for determining a precise position of the target. The present disclosed example can significantly improve the efficiency of positioning and effectively reduce the required cost of hardware.

Abstract: The present invention provides a processing circuit including logic cells and a thermal sensor. The thermal sensor is positioned within the logic cells and surrounded by the logic cells, and the logic cells and the thermal sensor are all implemented by core devices.

Abstract: Disclosures of the present invention describe an optical proximity sensor, which is particularly designed to have functionality of canceling an ambient light noise and/or an optical crosstalk noise by using light-to-frequency conversion technique, and comprises: a controlling and processing circuit, a lighting unit, a light receiving unit, an analog adder, a first DAC unit, a second DAC unit, and a light-to-digital conversion (LDC) unit. In the controlling of the controlling and processing circuit, the first DAC unit and the second DAC unit would respectively generate a first compensation current signal and a second compensation current signal to the analog adder, such that a noise signal of ambient light and a noise signal of optical crosstalk existing in an optical current signal of object reflection light would be canceled by the two compensation current signals in the analog adder.

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: A low power operation method provides an apparatus with a data transmission rate. A power management unit (PMU), which is not influenced by voltage, process, and temperature, biases a high frequency oscillator (HOSC) and makes the HOSC generate a steady and high precision clock. The clock of the HOSC is used to modify a timing length of a timer which is referenced by a low frequency oscillator (LOSC) without PMU. At last, through the modified timing length, the apparatus achieves high precision periods and data transmissions with compensation for voltage, process, and temperature. Thus, the data transmission cycles of the apparatus maintain stable and robust even if the apparatus applies duty cycle usage of the HOSC and the PMU for reducing power consumption with actions of turning on and turning off. Consequently, the periodic apparatus maintains data transmission rate with the low power consumption advantage of non-periodic apparatus.

Abstract: A low power operation method provides an apparatus with a data transmission rate. A power management unit (PMU), which is not influenced by voltage, process, and temperature, biases a high frequency oscillator (HOSC) and makes the HOSC generate a steady and high precision clock. The clock of the HOSC is used to modify a timing length of a timer which is referenced by a low frequency oscillator (LOSC) without PMU. At last, through the modified timing length, the apparatus achieves high precision periods and data transmissions with compensation for voltage, process, and temperature. Thus, the data transmission cycles of the apparatus maintain stable and robust even if the apparatus applies duty cycle usage of the HOSC and the PMU for reducing power consumption with actions of turning on and turning off. Consequently, the periodic apparatus maintains data transmission rate with the low power consumption advantage of non-periodic apparatus.

Abstract: A digital device is provided. The digital device uses three states, including a ground (GND) state, a voltage (VDD) state, and a FLOAT state. On designing a chip, two storage units and a pad circuit are set inside; the pad circuit comprises a current limiter and two switches; and less ports contained are required than the conventional. That is, one port obtains three states. As comparing to the conventional having only two states, the present invention uses the port connected with two storage units in the pad circuit for obtaining the three states; a circuit featuring “pull up” and “pull down” is used to identify the state of connection of the port; and the port determines a plurality of definitions through the three states of GND, VDD and FLOAT. Thus, a pad is saved for reducing the space and cost of the chip.

Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also disclosed is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. Further disclosed is a method for diagnosing a cell-mediated disorder by administering a PEG engager followed by a PEGylated diagnostic agent.

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: A smart method is provided for a low-current oscillatory circuitry. The circuitry comprises an oscillator and a microcontroller unit (MCU). The oscillator comprises a proportional-to-absolute-temperature circuit connecting to a low-voltage regulator. The low-voltage regulator connects to a PMOS diode array and a delay unit circuit. The PMOS diode array connects to the MCU. The delay unit circuit connects to the MCU and a voltage converter. The method includes a normal temperature compensation algorithm; a smart learning algorithm of extra-high temperature compensation; and an ultra-high temperature compensation algorithm. Thus, clock variations are compensated; output frequency is stable and not affected by voltage or temperature variations; and process variations are suppressed. When process variations appear, there are not be too many errors generated.

Abstract: A light sensor device is provided. It is controlled with a dual-mode master-and-slave microcontroller unit (MCU) application. An MCU is embedded into a light sensor chip. The original dual-mode master-and-slave dual-CPU architectures are combined to be operated as a single-CPU architecture. Since the original circuit pin design is followed, it is possible to be compatible with the old circuit design. The present invention uses a single-CPU architecture to directly control light sensors. Through the configuration of RAM, an inter-integrated circuit bus (I2C I/F) can be redirected to an internal non-volatile memory to switch the operational mode of the light sensor chip from a slave machine to a host machine which switches off the interrupt pin and, then, turns to a GPIO pin. Thus, the present invention provides a simple single-CPU architecture with easy use and effectively-lowered cost.

Abstract: Disclosures of the present invention describe an optical proximity sensor, which is particularly designed to have functionality of canceling an ambient light noise and/or an optical crosstalk noise by using light-to-frequency conversion technique, and comprises: a controlling and processing circuit, a lighting unit, a light receiving unit, an analog adder, a first DAC unit, a second DAC unit, and a light-to-digital conversion (LDC) unit. In the controlling of the controlling and processing circuit, the first DAC unit and the second DAC unit would respectively generate a first compensation current signal and a second compensation current signal to the analog adder, such that a noise signal of ambient light and a noise signal of optical crosstalk existing in an optical current signal of object reflection light would be canceled by the two compensation current signals in the analog adder.

Abstract: A light sensor device is provided. It is controlled with a dual-mode master-and-slave microcontroller unit (MCU) application. An MCU is embedded into a light sensor chip. The original dual-mode master-and-slave dual-CPU architectures are combined to be operated as a single-CPU architecture. Since the original circuit pin design is followed, it is possible to be compatible with the old circuit design. The present invention uses a single-CPU architecture to directly control light sensors. Through the configuration of RAM, an inter-integrated circuit bus (I2C I/F) can be redirected to an internal non-volatile memory to switch the operational mode of the light sensor chip from a slave machine to a host machine which switches off the interrupt pin and, then, turns to a GPIO pin. Thus, the present invention provides a simple single-CPU architecture with easy use and effectively-lowered cost.

Abstract: An image positioning system based on upsampling and a method thereof are provided. The image positioning method based on upsampling is to fetch a region image covering a target from a wide region image, determine a rough position of the target, execute an upsampling process on the region image based on neural network data model for obtaining a super-resolution region image, map the rough position onto the super-resolution region image, and analyze the super-resolution region image for determining a precise position of the target. The present disclosed example can significantly improve the efficiency of positioning and effectively reduce the required cost of hardware.

Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also provided is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. A kit that contains a PEG engager and a PEGylated anti-cancer agent is also disclosed. Further disclosed are methods for imaging cells and diagnosing cancer by administering a PEG engager followed by a PEGylated imaging agent. Another kit is provided that includes the PEG engager and the PEGylated imaging agent.