Patents by Inventor Yu-Chiau SHYU

Yu-Chiau SHYU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR ENHANCING LIFESPAN AND/OR TREATING CELLULAR PROLIFERATIVE DISORDERS BY TRANSPLANTATION
    Publication number: 20220143102
    Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.
    Type: Application
    Filed: January 28, 2022
    Publication date: May 12, 2022
    Inventors: Che-Kun James SHEN, Yu-Chiau SHYU, Chun-Hao HUNG
  • Methods for enhancing lifespan and/or treating cellular proliferative disorders by transplantation
    Patent number: 11266697
    Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: March 8, 2022
    Assignee: ACADEMIA SINICA
    Inventors: Che-Kun James Shen, Yu-Chiau Shyu, Chun-Hao Hung
  • Animal model of longevity and related methods for increasing longevity and inhibiting tumorigenesis
    Patent number: 11254719
    Abstract: A genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: February 22, 2022
    Assignee: Academia Sinica
    Inventors: Che-Kun James Shen, Yu-Chiau Shyu
  • ANIMAL MODEL OF LONGEVITY AND RELATED METHODS FOR INCREASING LONGEVITY AND INHIBITING TUMORIGENESIS
    Publication number: 20190367569
    Abstract: A genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.
    Type: Application
    Filed: July 23, 2019
    Publication date: December 5, 2019
    Inventors: Che-Kun James Shen, Yu-Chiau Shyu
  • METHODS FOR ENHANCING LIFESPAN AND/OR TREATING CELLULAR PROLIFERATIVE DISORDERS BY TRANSPLANTATION
    Publication number: 20190282625
    Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.
    Type: Application
    Filed: September 13, 2017
    Publication date: September 19, 2019
    Applicant: Academia Sinica
    Inventors: Che-Kun James SHEN, Yu-Chiau SHYU, Chun-Hao HUNG
  • Animal model of longevity and related methods for increasing longevity and inhibiting tumorigenesis
    Patent number: 10414809
    Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: September 17, 2019
    Assignee: Academia Sinica
    Inventors: Che-Kun James Shen, Yu-Chiau Shyu
  • ANIMAL MODEL OF LONGEVITY AND RELATED METHODS FOR INCREASING LONGEVITY AND INHIBITING TUMORIGENESIS
    Publication number: 20170283477
    Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.
    Type: Application
    Filed: September 1, 2015
    Publication date: October 5, 2017
    Inventors: Che-Kun James SHEN, Yu-Chiau SHYU