Patents by Inventor Yu-Chong Tai

Yu-Chong Tai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10617011
    Abstract: Methods, and devices produced by the methods, for electroplating a multitude of micro-scale electrodes that are electrically isolated from each other on a cable or other device is described. A localized area of connections on another end of the cable is shorted together by depositing a metal sheet or other conductive material over the localized area. The metal sheet is connected to a terminal of a power supply, and the electrode end of the cable is immersed in an electrolyte solution for electrodeposition by electroplating. After the electrodes are electroplated, the metal sheet is removed from the cable in order to re-isolate the electrodes.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 7, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Yu-Chong Tai, Han-Chieh Chang, Xiaoxiao Zhang
  • Publication number: 20200082926
    Abstract: Techniques are described for a non-invasive detection of a health condition of an organ. In an example, the electrical conductivity of the organ reflects the organ's health of. An inductive damping sensor can be used to detect the organ's electrical conductivity and, thus, its health. The inductive damping sensor can be placed in proximity of the organ such as the organ is within the magnetic field generated based on a coil of the inductive damping sensor. The conductivity of the organ impacts the inductance and the resistance of the coil. Hence, the inductance and/or resistance of the coil can be measured, where the measurements can be associated with the health of the organ.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 12, 2020
    Inventors: Yu-Chong Tai, Tzu-Chieh Chou, Shane S. Shahrestani
  • Publication number: 20200054442
    Abstract: Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. Each radioluminescent light source includes an interior chamber coated with phosphor material, such as zinc sulfide, and containing a radioisotope material, such as gaseous tritium. The volume, shape, phosphor material, and radioisotope material are selected for emission of light at a particular wavelength and delivering a particular irradiance on the retina (when implanted in an eyeball). The wavelength is in the range of 400 to 600 nm and the irradiance is substantially 109 to 1011 photons per second per cm2.
    Type: Application
    Filed: October 28, 2019
    Publication date: February 20, 2020
    Inventors: Yu-Chong Tai, Colin A. Cook
  • Patent number: 10512534
    Abstract: Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. Each radioluminescent light source includes an interior chamber coated with phosphor material, such as zinc sulfide, and containing a radioisotope material, such as gaseous tritium. The volume, shape, phosphor material, and radioisotope material are selected for emission of light at a particular wavelength and delivering a particular irradiance on the retina (when implanted in an eyeball). The wavelength is in the range of 400 to 600 nm and the irradiance is substantially 109 to 1011 photons per second per cm2.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: December 24, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Yu-Chong Tai, Colin A Cook
  • Publication number: 20190374381
    Abstract: An eye treatment apparatus is described. The apparatus includes an annular body that has a hollow optical zone in its center. An inner perimeter of the annular body surrounds the optical zone. The inner perimeter has a diameter that corresponds to a diameter of the eye's cornea. An outer perimeter of the annular body has a diameter such that the annular body can extend to underneath the eye lid in an open eye position when the eye treatment apparatus is in operation. In this way, the apparatus can be worn on the eye, where the hollow optical zone substantially corresponds to the cornea and does not interfere with the field of vision. The annular body also includes a storage chamber that stores therapeutic liquid for an eye. An outlet is coupled with the storage chamber such that, in operation, the therapeutic liquid can be dispensed to the eye.
    Type: Application
    Filed: June 11, 2019
    Publication date: December 12, 2019
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Colin A. Cook, Mark S. Humayun
  • Patent number: 10492945
    Abstract: An implantable medical device is described. The implantable medical device includes an anti-condensation filler that is highly permeable to a predetermined class of small molecules, such as oxygen. The implantable medical device includes a small molecule discharge bag that is permeable to the small molecule, and a cannula that connects an interior of the small discharge bag to the anti-condensation filler. In operation, small molecules are collected and transported through the anti-condensation filler to the cannula for diffusion through the small molecule discharge bag. Even when this device is implanted in a high humidity and temperature gradient environment, the anti-condensation filler prevents condensation, such as water condensation.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: December 3, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Yu-Chong Tai, Nicholas Scianmarello, Colin A. Cook
  • Publication number: 20190358082
    Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 28, 2019
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Aubrey M. Shapero, Nicholas E. Scianmarello, Mark S. Humayun
  • Patent number: 10478206
    Abstract: Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: November 19, 2019
    Assignees: University of Southern California, California Institute of Technology, The Regents of the University of California
    Inventors: Mark Humayun, Ashish Ahuja, Yu-Chong Tai, Robert Grubbs, Rodrigo Brant, Trent Wells, Lincoln Vallance Johnson, Sherry T. Hikita, David Hinton
  • Patent number: 10450677
    Abstract: A parylene microcapillary is manufactured by drawing a polyethylene carbonate (PEC) fiber from a 0° C. solution of 12-25% PEC in chloroform to create a PEC fiber that has a constant diameter over several centimeters. Parylene is deposited in a chamber over the PEC fiber, and then the coated PEC fiber is heated above 180° C. This heating melts and decomposes the PEC fiber such that it self-expels from the coating, leaving a microcapillary. The self-expulsion allows for meters-long lengths of microcapillaries. Alternatively, a serpentine fiber channel of PEC is created by deposition, photolithography, and etching within a sandwich of parylene. It is heated above 180° C. to expel the PEC leaving a hollow channel within a mass of parylene. The resulting microcapillaries may have residues of cyclic ethylene carbonate remaining from the decomposed PEC.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: October 22, 2019
    Assignee: California Institute of Technology
    Inventors: Tzu-Chieh Chou, Yu-Chong Tai, Yudan Pi
  • Publication number: 20190307928
    Abstract: A polymeric substrate for treating a chondral or osteochondral defect includes a polymeric sheet having a predetermined shape and size for placement over a chondral or osteochondral defect. The polymeric sheet defines suture openings therein that allow fixation of the polymeric scaffold. Characteristically, the polymeric sheet includes biocompatible polymer. A method for treating a subject having a chondral or osteochondral defect is also provided.
    Type: Application
    Filed: April 8, 2019
    Publication date: October 10, 2019
    Inventors: Mark S. Humayun, Carlos Eduardo da Silveira Franciozi, Tzu-Chieh Chou, Yu-Chong Tai, Damien C. Rodger, C. Thomas Vangsness, JR.
  • Patent number: 10371640
    Abstract: The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: August 6, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Yu-Chong Tai, Wendian Shi, Harvey Kasdan
  • Publication number: 20190232078
    Abstract: Embodiments of the present disclosure are directed to a wearable phototherapy eye device. In an example, phototherapy can be controlled by varying an emission property of light emitted from the wearable phototherapy eye device to a user eye. In particular, the wearable phototherapy eye device includes a light source oriented to emit the light towards the user eye. The wearable phototherapy eye device also includes controls, such as electrical, mechanical, and/or electro-mechanical controls, to vary the emission property of the light based on an emission target associated with a sleep phase.
    Type: Application
    Filed: January 30, 2019
    Publication date: August 1, 2019
    Applicant: California Institute of Technology
    Inventors: Yu-Chong Tai, Colin A. Cook
  • Publication number: 20190218687
    Abstract: A parylene microcapillary is manufactured by drawing a polyethylene carbonate (PEC) fiber from a 0° C. solution of 12-25% PEC in chloroform to create a PEC fiber that has a constant diameter over several centimeters. Parylene is deposited in a chamber over the PEC fiber, and then the coated PEC fiber is heated above 180° C. This heating melts and decomposes the PEC fiber such that it self-expels from the coating, leaving a microcapillary. The self-expulsion allows for meters-long lengths of microcapillaries. Alternatively, a serpentine fiber channel of PEC is created by deposition, photolithography, and etching within a sandwich of parylene. It is heated above 180° C. to expel the PEC leaving a hollow channel within a mass of parylene. The resulting microcapillaries may have residues of cyclic ethylene carbonate remaining from the decomposed PEC.
    Type: Application
    Filed: January 17, 2019
    Publication date: July 18, 2019
    Applicant: California Institute of Technology
    Inventors: Tzu-Chieh Chou, Yu-Chong Tai, Yudan Pi
  • Patent number: 10342698
    Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: July 9, 2019
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTE
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
  • Publication number: 20190183392
    Abstract: The present invention provides devices for characterizing regions of tissue and methods for using the same. The devices are capable of locating, identifying, and characterizing tissue regions of interest in vivo. In one embodiment, the devices are ultrasound-guided. In one embodiment, the devices use characterize regions of tissue using electrical impedance spectroscopy (EIS) sensors. In one aspect, the devices are useful in predicting plaque rupture, such as by determining the level of oxidized low density lipoprotein (oxLDL) and macrophage/foam cells present in an atheroma. In one aspect, the devices are useful in identifying metabolically active atherosclerotic lesions that are angiographically invisible.
    Type: Application
    Filed: May 9, 2017
    Publication date: June 20, 2019
    Inventors: Tzung K. Hsiai, Yu-Chong Tai, Rene R. Sevag Packard, Yuan Luo, Parinaz Abiri, Jianguo Ma
  • Publication number: 20190151499
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 23, 2019
    Applicants: University of Southern California, California Institute of Technology, The Regents of the University of California
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Patent number: 10287451
    Abstract: A composition of matter is described in which a porous material, such as polydimethylsiloxane (PDMS), is coated with parylene N, C, D, or AF-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: May 14, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Yu-Chong Tai, Dongyang Kang
  • Patent number: 10261088
    Abstract: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 16, 2019
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Amir Goldkorn, Yu-Chong Tai, Tong Xu, Bo Lu
  • Patent number: 10251780
    Abstract: A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: April 9, 2019
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Yu Zhao, Mark S. Humayun, James D. Weiland
  • Patent number: 10240689
    Abstract: Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded o the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: March 26, 2019
    Assignee: MINIPUMPS, LLC
    Inventors: Yu-Chong Tai, Po-Ying Li, Fukang Jiang, Changlin Pang, Natasha Yvette Bouey, Man Ting Chou, Atoosa Lotfi