Abstract: The present disclosure relates to the antibodies specific targeting CD142, antibody-drug conjugates, preparations and uses thereof. The antibody or antigen-binding fragment thereof binding to CD142 is covalently linked to a cytotoxic payload through a linker. The antibody or antigen-binding fragment thereof binding to CD142 and the antibody-drug conjugate exhibit cytotoxic effects on tumor cells.

Abstract: A display panel is provided. The display panel includes a substrate, and a plurality of pixel units and an organic insulating layer disposed on the substrate. The organic insulating layer is disposed between a driver circuit and a light-emitting unit of the pixel unit. A lens assembly is arranged on a surface, away from the substrate, of a portion of the organic insulating layer within a light-emitting region of any of the plurality of pixel units. The lens assembly comprises a plurality of lenses with adjacent lenses forming taper structures. A first surface and a second surface, away from the substrate, of the taper structure are configured to reflect light, that is confined to the interior of the display panel, to a light-emitting side.

Abstract: A general formula for lysins based on which the activity and functionality are further screened and 24 lysins are identified and further investigated, nine of which are characterized. These lysins exhibit potent bactericidal activity, capable of lysing multiple species of Staphylococcus, Streptococcus, and/or Enterococcus; demonstrate robust environmental resistance and stability, retaining activity under varying temperatures, NaCl concentrations, pH levels, and in immune serum; and effectively treat localized and systemic infections. These lysins and their variants are promising as antimicrobial agents for eradicating bacteria, preventing bacterial infections, or treating bacterial infections (caused by genera Staphylococcus, Streptococcus, and/or Enterococcus).

Abstract: The present application relates to a PDU power distribution apparatus, comprising a housing, the housing is provided with a conductor assembly facing a bottom of the housing, a fixing element is provided between the conductor assembly and the housing for fixing the conductor assembly, a protecting seat is provided inside the housing for protecting the conductor assembly, and the protecting seat is provided with a through hole for inserting and connecting a power adapter, a pre-installed seat is provided inside the housing for installing the power adapter, and the pre-installed seat is located on a side of the protecting seat departing from the conductor assembly, the pre-installed seat is provided with a socket for inserting and connecting the power adapter on a side facing the conductor assembly, and the pre-installed seat is connected to the housing.

Abstract: Machine learning, artificial intelligence, and other computer-implemented methods are used to identify various semantically important chunks in documents, automatically label them with appropriate datatypes and semantic roles, and use this enhanced information to assist authors and to support downstream processes. Chunk locations, datatypes, and semantic roles can often be automatically determined from what is here called “context”, to wit, the combination of their formatting, structure, and content; those of adjacent or nearby content; overall patterns of occurrence in a document, and similarities of all these things across documents (mainly but not exclusively among documents in the same document set).

Abstract: Systems and methods for performing a medical imaging analysis task using a foundation model are provided. One or more 3D (three-dimensional) medical images each comprising a plurality of 2D (two-dimensional) slices are received. A first set of features is extracted from the plurality of 2D slices of the one or more 3D medical images using a machine learning based encoding network. Each respective feature of the first set of features is resampled based on a spatial location of one or more pixels of the 2D slices from which the respective feature was extracted. The resampled first set of features is encoded into a second set of features. A medical imaging analysis task is performed based on the second set of features. Results of the medical imaging analysis task are output.

Abstract: Systems and methods for navigating a catheter in a patient using a robotic navigation system with risk management are provided. An input medical image of a patient is received. A trajectory for navigating a catheter from a current position to a target position in the patient is determined based on the input medical image using a trained segmentation network. One or more actions of a robotic navigation system for navigating the catheter from the current position towards the target position and a confidence level associated with the one or more actions are determined by a trained AI (artificial intelligence) agent and based on the generated trajectory and a current view of the catheter. In response to the confidence level satisfying a threshold, the one or more actions are evaluated based on a view of the catheter when navigated according to the one or more actions.

Abstract: Described herein are synthetic promoters and/or enhancers that are specific for cancer cells and methods of engineering synthetic cancer-specific promoters.

Abstract: A bonding tool replacement apparatus for inserting a bonding tool into a retaining hole of a wire bonding apparatus includes a frame, a bonding tool gripper and a compliant structure. The bonding tool gripper is supported by the frame and configured to grip the bonding tool and insert it into the retaining hole at an operation position associated with the wire bonding apparatus by moving the bonding tool toward the retaining hole. The compliant structure flexibly couples the bonding tool gripper to the frame to enable relative movement of the bonding tool gripper with respect to the frame. The compliant structure is configured to deform in response to misalignment between the bonding tool gripped by the bonding tool gripper and the retaining hole during insertion to allow the bonding tool to deflect into alignment with the retaining hole when the bonding tool and the retaining hole are misaligned.

Abstract: The present disclosure discloses a modular smart body fat scale with a pet body configuration detection function, including a main body base and a wireless display. An installing cavity is formed in a front side of the top of the main body base, four weighting sensors arranged at equal intervals are disposed at the inside top of the installing cavity, an installing box is disposed at a top end of the weighting sensor, a matrix grid electrode is disposed inside the installing box, and a cover plate is disposed on the top of the installing box. A support frame bottom groove is formed in the back portion of the top of the main body base, a bottom motor box is disposed in the inside middle portion of the support frame bottom groove, a support upright post is disposed on a top end of the bottom motor box.

Abstract: Provided is a display panel including: a substrate, a plurality of pixels, and a pixel definition layer. In a plurality of sub-pixels contained in each pixel, at least two sub-pixels are disposed in different rows, homochromatic sub-pixels are disposed in a same column, and heterochromatic sub-pixels are disposed in different columns. The pixel definition layer includes a plurality of definition portions and a plurality of communication portions. The plurality of sub-pixels are within a plurality of openings defined by the definition portions and the communication portions. Each definition portion is configured to define, in the pixel row direction and the pixel column direction, the respective heterochromatic sub-pixels adjacent to each other. Each communication portion is configured to be in communication, in the pixel column direction, with the respective homochromatic sub-pixels adjacent to each other. A thickness of the definition portion is greater than a thickness of the communication portion.

Abstract: Described herein are synthetic promoters and/or enhancers that are specific for cancer cells and methods of engineering synthetic cancer-specific promoters.

Abstract: Systems and methods include an optimization-based load planning module including a data-reduction scheme for analyzers of bio-fluid samples. The optimization-based load planning module is executable on a computer server and is configured to optimize assay type assignments across a large number of analyzers based on one or more objectives, such as: load balancing, efficient reagent usage, reduced turn-around-time, reduced quality assurance costs, and/or improved system robustness. The optimization-based load planning module uses a data-reduction scheme to generate a load plan comprising computer-executable instructions configured to cause a system controller of a diagnostic laboratory system to assign each of the requested test types to be performed over the planning period to one or more selected analyzers in accordance with the one or more preferences or priorities. Other aspects are also described.

Abstract: The present disclosure provides an under-wire spray cleaning device for a wire cutting machine including: a spray assembly connected to a trough body, wherein the trough body is entirely disposed in an engaging slot of a nozzle pipe device; wherein the spray assembly includes first nozzles disposed on an inside of the trough body and second nozzles disposed on an outside of the trough body, the first nozzles are configured to clean a feed machine and a clamping mushroom head, and the second nozzles are configured to clean a sheave of the outside of the trough body. An advantage of the present disclosure is changing manually cleaning to cleaning by a spray device, which drastically improves cleaning efficiency and also prevents influence of human factors to cleanliness of the machine.

Abstract: Disclosed herein are methods and systems using artificial intelligence models to predict systematic changes in radiation therapy. The system can generate a first radiotherapy treatment plan using a first medical image depicting at least an anatomical region of a patient. After at least one treatment fraction has been implemented, the system can acquire a second medical image depicting the anatomical region. The system can execute a computer model to compare the first medical image with the second medical image. After at least one subsequent treatment fraction, the system can acquire a third medical image and compare the first medical image with the third medical image. The system can execute, using the medical images, a machine learning model to predict anatomical changes to at least one structure of the patient for the forecasted treatment fraction. The system can transmit the predictions to a radiotherapy treatment planning computer model.

Abstract: The present disclosure relates to the technical field of tests, and in particular, to a thin test strip, a test strip roll, and an application of the thin test strip. The thin test strip includes: a waterproof top layer, a composite layer, and a waterproof bottom layer in sequence from top to bottom, where the composite layer includes a sample collection pad, a colloidal gold conjugate pad, a color developing membrane, and a sample absorption pad, the waterproof top layer does not cover the sample collection pad and completely covers the colloidal gold conjugate pad, the color developing membrane, and the sample absorption pad, and the composite layer is I-shaped. The waterproof top layer and the waterproof bottom layer are made from polyethylene terephthalate (PET) waterproof transparent membranes.

Abstract: A water distribution regulation method for reclaimed waterway landscape environment based on algae risk control, comprising: according to the water source characteristics of seasonal river landscape environment water and the hydraulic characteristics of river water, based on the algae growth curve of indicative algae species, controlling algae risk with nitrogen-phosphorus ratio and water replacement rate as control indicators; based on the nitrogen-phosphorus ratio and water replacement rate, constructing a joint regulation model for water-quantity and water-quality of the river incorporating reclaimed water; based on the joint regulation model, optimizing the nitrogen-phosphorus ratio of the river water environment with the indicative algae species; based on the optimized nitrogen-phosphorus ratio, optimizing the joint regulation model; and utilizing the optimized joint regulation model to perform joint regulation of water quantity and water quality.

Abstract: A content extraction method and apparatus including presenting a document selection interface based on an uploading operation in an information exchange interface, the document selection interface comprising at least one document, based on a selection operation on a first document of the at least one document, presenting, in the information exchange interface, the first document and processing information of the first document in a status area corresponding to the first document, the processing information indicating a current processing stage in a process of performing content extraction on the first document and a corresponding processing status, and after the content extraction on the first document is completed, removing display of the status area, and presenting, in the information exchange interface, a document digest obtained by performing content extraction on the first document.

Abstract: The invention relates to the technical field of bioengineering and provides a method for improving the specificity and affinity of an aptamer. The method includes: S1, screening a target of an aptamer from a compound information database by virtual computing; S2, verifying the screening result in Step S1 through experiments; S3, performing virtual saturation mutation on a site of the aptamer, and screening out a mutation site of the aptamer; S4, performing base substitution to the mutation site of the aptamer; and S5, detecting the binding parameter of the aptamer after base substitution with the target screened in Step S1, and selecting an aptamer with improved specificity and affinity after base substitution. An efficient molecular design-guided method is developed by computer rational calculation, to improve the specificity and binding affinity of the aptamer by directional modification. The present invention is of great significance for the practical application of aptamers.

Abstract: An assessment apparatus and method for objective pain assessment are provided, wherein the apparatus includes a processor comprising a frequency-domain transformation module, a frequency-band segmentation module, a first assessment submodule, and a second assessment submodule. The frequency-domain transformation module generates a global time-frequency feature matrix, which is segmented by the frequency-band segmentation module in a frequency domain into five frequency bands associated with pain perception. The first assessment submodule extracts last time step features and an adjacency matrix from the time-frequency feature matrix and generates a first feature vector representing global association patterns among electrodes used for acquiring EEG signals.