Abstract: A clamp fixture with multi-directional opening comprises a front clamping head, a rear clamping base, a top and a bottom pressing plates and two latching bases. The latching bases are provided on top of the front clamping head and the rear clamping bases respectively. Each of the latching bases further comprises a bracket, a pin shaft, a thumb latch and a torsion spring. The thumb latch can be pressed down to securely position the top pressing plate, cooperating with the bottom pressing plate which feeds through the front clamping head and the rear clamping base to form a space for securely clamping the working objects with multiple panels. The operation is simple and the structure is compact.