Patent number: 12487236
Abstract: Described is a polypeptide magnetic nanoparticle having a specific targeting polypeptide and a magnetic nanoparticle. The amino acid sequence of the specific targeting polypeptide is VRRDAPRFSMQGLDA-X, and the C-terminal X thereof is a sequence of 5 to 20 amino acids. The amino acid in the amino acid sequence of C-terminal X is selected from one or more of: C, G, and N. The polypeptide magnetic nanoparticle can be used for CTC detection and molecular typing of various cancer types, including esophageal cancer, liver cancer, lung cancer, stomach cancer, bladder cancer, skin cancer, melanoma, breast cancer, colorectal cancer, cervical cancer, etc. Biomarkers of CTC molecular typing include PD-L1, HER2, ER, PR, AR, EGFR, VEGFR, CXCR4, etc.
Type:
Grant
Filed:
May 19, 2020
Date of Patent:
December 2, 2025
Assignee:
BEIJING NANOPEP BIOTECH CORPORATION, LTD.
Inventors:
Tao Jiang, Nannan Li, Jian Xue, Xuejiao Bai, Qian Yu, Da Li, Zhen Cai, Qian Cai, An Xu, Haiyan Qiu, Yu Han, Ran Wang