Abstract: A carbon black is provided. The carbon black is produced through heat treatment of recycled carbon black. Since the carbon black is made from recycled carbon black, it is a kind of environmentally friendly carbon black.

Abstract: The present invention provides a detecting system and a detecting method for movement trajectory. The detecting method includes: transmitting a radar signal to a detection area to receive a corresponding reflected signal; obtaining a point cloud according to the reflected signal; generating a movement trajectory according to the point cloud; and displaying information associated with the movement trajectory through a graphical user interface.

Abstract: Adoptive T-cell therapy has shown tantalizing promise as a cancer treatment strategy, with several clinical trials reporting that T cells expressing chimeric antigen receptors (CARs) can eradicate tumors in patients with relapsed disease. However, CAR-T cells rely on receptor-mediated recognition of surface-bound antigens that are seldom tumor-exclusive, resulting in severe on-target, off-tumor toxicities that have led to patient deaths in clinical trials. There is a growing consensus that the lack of suitable antigens poses a major obstacle to the broad application of engineered tumor-targeting T cells. The ability to overcome T cells' reliance on surface antigen presentation and interrogate intracellular disease signatures would significantly expand the pool of detectable tumor markers and improve tumor-targeting specificity. Here, we present a novel strategy to reprogram T-cell-mediated cytotoxicity to interrogate intracellular disease signatures.

Abstract: A device control method, a memory storage device, and a memory control circuit unit are disclosed. The method includes: establishing a connection between the memory storage device and a host system; performing a first communication with the host system based on the connection and a first connection interface standard; performing a data recovery operation between the memory storage device and the host system via the connection during a period of performing the first communication; and switching to perform a second communication with the host system based on the connection and a second connection interface standard in a case that the data recovery operation is successfully performed, wherein the first connection interface standard is different from the second connection interface standard.

Abstract: Aspects of the disclosure relate to novel scFv molecules that are useful for incorporation into novel chimeric antigen receptors with enhance anti-tumor activity. Further aspects relate to a polypeptide comprising a CAR comprising, in order from amino proximal to carboxy proximal end, a scFv, a transmembrane domain, a torsional linker, and a cytoplasmic region comprising a primary intracellular signaling domain, wherein the torsional linker comprises 1-12 alanine residues. Also described are nucleic acids comprising a sequence encoding a polypeptide of the disclosure, vectors, such as lentiviral vectors comprising the nucleic acids of the disclosure, cells comprising and/or expressing nucleic acids and/or polypeptides of the disclosure, and populations of cells comprising the cell embodiments of the disclosure. Also provided are methods of making cells that express a polypeptide and methods of treating patients with the polypeptides and cell compositions of the disclosure.

Abstract: The current application fulfills a need for methods of making bi-specific CAR T-cells that have high efficacy. Aspects of the disclosure relate to a method for manufacturing a CD19/CD20 bi-specific chimeric antigen receptor (CAR) T cell comprising the ordered steps of: (a) providing a composition comprising a population of cells comprising T cells; (b) contacting the composition comprising the population of cells comprising T cells with one or more of a transactivating composition, IL-2, and/or IL-15; (c) transducing the cell composition from (b) with a CD19/CD20 bi-specific CAR nucleic acid; and (d) removing the transactivating composition from the cell composition of (c). Further aspects relate to a population of CD19/CD20 bi-specific CAR-T cells produced by the methods of the disclosure. Yet further aspects describe a method for treating a subject for B-cell lymphoma comprising administering cells of the disclosure.

Abstract: Systems and methods for global positioning satellite (GPS)/global navigation satellite system (GNSS) based real time global asset tracking are described. In an embodiment provides a system for real time, fast, global asset tracking, the system includes: a server with a processor, a memory, and a network interface, wherein the memory includes a tracking application, where the tracking application directs the processor to: receive a message including specific data from a tag; determine a time search window based on the message received from the tag; perform an initial position search; perform calculations for position and time, utilizing the time search window, the initial position search and satellite ephemeris information; and display a position information of the tag.

Abstract: A carrier for solid state devices includes a plurality of panels, at least one gate, and an addition. The plurality of panels includes a first panel, a second panel, and a third panel. The at least one gate is attached to the second panel and the third panel. The at least one gate is configured to be in one of a first position or a second position. When the at least one gate is in the first position, an opening for receiving solid state devices is at least partially occluded to a first width that is smaller than a length of one of the solid state devices. When the at least one gate is in the second position, the opening for receiving the solid state devices is increased to a second width that is larger than the length of the one of the solid state devices.

Abstract: A secondary-side protection and sense circuit for a power converter has a sensing component, an adder amplifying circuit, an electronic switch, and a charge/discharge circuit. The sensing component is connected to an output connecting terminal of the power converter. The adder amplifying circuit has an operational amplifier, a first resistor, and a second resistor. The operational amplifier has an input terminal connected to the sensing component, an output terminal connected to a primary-side control component, and a power terminal. The first resistor and the second resistor are connected in series and between the input terminal and the power terminal of the operational amplifier. The electronic switch is connected between a ground terminal and a connection node between the first resistor and the second resistor. The charge/discharge circuit is connected to the electronic switch and the power terminal of the operational amplifier.

Abstract: A device for encouraging and guiding a spirometer user includes a housing, a main valve, a visual assembly, and a sound making assembly. The housing has a guiding channel, a first outlet channel, a second outlet channel, and an inlet channel. The main valve is disposed in a housing communicating with the guiding channel, the first outlet channel, the second outlet channel or the inlet channel and configured to regulate or control fluid flowing paths. The visual assembly includes a check valve in the second outlet channel, and at least one movable member. The sound making assembly includes a check valve and a sound maker. So, it can generate the visual and sound encouraging effects for learning how to use a spirometer correctly.

Abstract: A jaundice analysis system includes a database and a processing device for accessing the database. The processing device includes: a data processing module for generating a training data according to an image data, correlating the training data with a category data, and storing the training data in the database; and a deep learning module for training a target convolutional neural network module with the training data correlating with the category data to obtain a trained convolutional neural network module. The image data includes a first sclera image. The trained convolutional neural network module of the processing device generates a testing data according to an input image data. The input image data includes a second sclera image of a target subject. The testing data indicates the target subject's bilirubin concentration range.

Abstract: Systems and methods for global positioning satellite (GPS)/global navigation satellite system (GNSS) based real time global asset tracking are described. In an embodiment provides a system for real time, fast, global asset tracking, the system includes: a server with a processor, a memory, and a network interface, wherein the memory includes a tracking application, where the tracking application directs the processor to: receive a message including specific data from a tag; determine a time search window based on the message received from the tag; perform an initial position search; perform calculations for position and time, utilizing the time search window, the initial position search and satellite ephemeris information; and display a position information of the tag.

Abstract: Disclosed are compositions comprising an isolated chimeric interleukin 6 receptor alpha (IL-6R?) binding protein or cells expressing an isolated chimeric IL-6R? binding protein. The isolated IL-6R? chimeric binding protein and cells expressing the protein may be used in methods of treating cancer and reducing the risk of cytokine release syndrome.

Abstract: The current disclosure provides for novel multi-specific CAR molecules for the treatment of glioblastoma (also called GBM or glioblastoma multiforme). This disclosure also describes nucleic acids encoding for the polypeptides, expression vectors comprising the nucleic acids, cells and/or populations of cells expressing the polypeptides and/or comprising the nucleic acids or expression vectors of the disclosure, and compositions comprising the polypeptides, nucleic acids, or cells.

Abstract: Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.

Abstract: The current disclosure provides for novel multi-specific CAR molecules for the treatment of glioblastoma (also called GBM or glioblastoma multiforme). This disclosure also describes nucleic acids encoding for the polypeptides, expression vectors comprising the nucleic acids, cells and/or populations of cells expressing the polypeptides and/or comprising the nucleic acids or expression vectors of the disclosure, and compositions comprising the polypeptides, nucleic acids, or cells.

Abstract: A secondary-side protection and sense circuit for a power converter has a sensing component, an adder amplifying circuit, an electronic switch, and a charge/discharge circuit. The sensing component is connected to an output connecting terminal of the power converter. The adder amplifying circuit has an operational amplifier, a first resistor, and a second resistor. The operational amplifier has an input terminal connected to the sensing component, an output terminal connected to a primary-side control component, and a power terminal. The first resistor and the second resistor are connected in series and between the input terminal and the power terminal of the operational amplifier. The electronic switch is connected between a ground terminal and a connection node between the first resistor and the second resistor. The charge/discharge circuit is connected to the electronic switch and the power terminal of the operational amplifier.

Abstract: Disclosed are compositions comprising an isolated chimeric interleukin 6 receptor alpha (IL-6R?) binding protein or cells expressing an isolated chimeric IL-6R? binding protein. The isolated IL-6R? chimeric binding protein and cells expressing the protein may be used in methods of treating cancer and reducing the risk of cytokine release syndrome.

Abstract: Systems and methods for global positioning satellite (GPS)/global navigation satellite system (GNSS) based real time global asset tracking are described. In an embodiment provides a system for real time, fast, global asset tracking, the system includes: a server with a processor, a memory, and a network interface, wherein the memory includes a tracking application, where the tracking application directs the processor to: receive a message including specific data from a tag; determine a time search window based on the message received from the tag; perform an initial position search; perform calculations for position and time, utilizing the time search window, the initial position search and satellite ephemeris information; and display a position information of the tag.

Abstract: Aspects of the disclosure relate to novel scFv molecules that are useful for incorporation into novel chimeric antigen receptors with enhance anti-tumor activity. Further aspects relate to a polypeptide comprising a CAR comprising, in order from amino proximal to carboxy proximal end, a scFv, a transmembrane domain, a torsional linker, and a cytoplasmic region comprising a primary intracellular signaling domain, wherein the torsional linker comprises 1-12 alanine residues. Also described are nucleic acids comprising a sequence encoding a polypeptide of the disclosure, vectors, such as lentiviral vectors comprising the nucleic acids of the disclosure, cells comprising and/or expressing nucleic acids and/or polypeptides of the disclosure, and populations of cells comprising the cell embodiments of the disclosure. Also provided are methods of making cells that express a polypeptide and methods of treating patients with the polypeptides and cell compositions of the disclosure.