Patents by Inventor Yu-Hsuan SHIH

Yu-Hsuan SHIH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240218856
    Abstract: A force measurement apparatus adapted to be installed on a pile includes at least one pressing ring and a plurality of force sensors. The pressing ring includes a ring body and at least one pressing part. The ring body has at least one end and an inner surface facing the pile. The pressing part is disposed at the end. The force sensor is disposed between the inner surface of the ring body and the pile so as to sense a radial deformation and the degree of eccentricity of the pile.
    Type: Application
    Filed: April 25, 2023
    Publication date: July 4, 2024
    Applicant: Industrial Technology Research Institute
    Inventors: Yu-Hsuan Shih, Che-Kai Yeh, Tzung-Ching Lee, Chao-Ta Huang
  • Patent number: 8722880
    Abstract: A method for preparing 42-(dimethylphosphinate) Rapamycin (Ridaforolimus) (I) is provided, which has advantages of high conversion rate and no 31,42-bis(dimethyl phosphinate) Rapamycin (III) generated. In the method of the present invention, Rapamycin (II) is firstly reacted with triethyl chlorosilane in a base condition to form 31,42-bis(triethylsilylether) Rapamycin (IV-b), followed by a selective deprotection process to obtain 31-triethylsilylether Rapamycin (V-b). Next, a phosphorylation reaction is performed by using dimethylphosphinic chloride under a base solution to obtain a crude product. Finally, a deprotection reaction is performed in a diluted sulfuric acid solution to obtain a crude product of Ridaforolimus (I). Since the conversion rate of each step of the method of the present invention is higher than 98%, it indicates that the method of the present invention is suitable for industrial production.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: May 13, 2014
    Assignee: Chunghwa Chemical Synthesis & Biotech Co., Ltd.
    Inventors: Kwang-Chung Lee, Yen-Shih Tung, Tzu-Ai Lee, Yu-Hsuan Shih
  • Publication number: 20140058081
    Abstract: A method for preparing 42-(dimethylphosphinate) Rapamycin (Ridaforolimus) (I) is provided, which has advantages of high conversion rate and no 31,42-bis(dimethyl phosphinate) Rapamycin (III) generated. In the method of the present invention, Rapamycin (II) is firstly reacted with triethyl chlorosilane in a base condition to form 31,42-bis(triethylsilylether) Rapamycin (IV-b), followed by a selective deprotection process to obtain 31-triethylsilylether Rapamycin (V-b). Next, a phosphorylation reaction is performed by using dimethylphosphinic chloride under a base solution to obtain a crude product. Finally, a deprotection reaction is performed in a diluted sulfuric acid solution to obtain a crude product of Ridaforolimus (I). Since the conversion rate of each step of the method of the present invention is higher than 98%, it indicates that the method of the present invention is suitable for industrial production.
    Type: Application
    Filed: August 15, 2013
    Publication date: February 27, 2014
    Applicant: Chunghwa Chemical Synthesis & Biotech Co., Ltd.
    Inventors: Kwang-Chung LEE, Yen-Shih TUNG, Tzu-Ai LEE, Yu-Hsuan SHIH