Patents by Inventor Yu-Hua Ji

Yu-Hua Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrrolidine and related compounds
    Patent number: 7183292
    Abstract: This invention is directed to compounds of formula I: wherein R1–R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. The invention also directed to pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors using such compounds.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: February 27, 2007
    Assignee: Theravance, Inc.
    Inventors: Mathai Mammen, Adam Hughes, Yu-hua Ji, Li Li, Weijiang Zhang
  • Diphenylmethyl compounds useful as muscarinic receptor antagonists
    Publication number: 20070032524
    Abstract: This invention provides compounds of formula I: wherein a, b, c, e, m, R1, R2, R3, R4a, R4b, R5, R6, R7 and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: October 5, 2006
    Publication date: February 8, 2007
    Inventors: Mathai Mammen, Yu-Hua Ji, Sarah Dunham, Li Li
  • Protein kinase inhibitors
    Patent number: 7173039
    Abstract: Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or more linking groups. Such compounds are useful for treating diseases or medical disorders mediated by protein kinases.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: February 6, 2007
    Assignee: Theravance, Inc.
    Inventors: John H. Griffin, Yu-Hua Ji, Edmund J. Moran, Jonathan W. Wray
  • Diphenylmethyl compounds useful as muscarinic receptor antagonists
    Patent number: 7151115
    Abstract: This invention provides compounds of formula I: wherein a, b, c, e, m, R1, R2, R3, R4a, R4b, R5, R6, R7 and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: December 19, 2006
    Assignee: Theravance, Inc.
    Inventors: Mathai Mammen, Yu-Hua Ji, Sarah Dunham, Li Li
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20060281740
    Abstract: The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: June 12, 2006
    Publication date: December 14, 2006
    Inventors: Yu-Hua Ji, Mathai Mammen, Craig Husfeld, Li Li, YongQi Mu, Aaron Kushner, Eric Stangeland, Trevor Mischki, Adam Hughes, Sarah Dunham
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20060205777
    Abstract: The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 14, 2006
    Inventors: YongQi Mu, Yu-Hua Ji, Mathai Mammen, Viengkham Malathong
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20060205775
    Abstract: The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 14, 2006
    Inventors: Yu-Hua Ji, Craig Husfeld, Li Li, Mathai Mammen, YongQi Mu, Eric Stangeland
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20060205946
    Abstract: The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 14, 2006
    Inventors: Yu-Hua Ji, Craig Husfeld, Mathai Mammen, YongQi Mu, Eric Stangeland
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20060205779
    Abstract: The invention provides compounds of formula I: wherein a, b, c, p, W, A, X1, R1, R2, R3, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 14, 2006
    Inventors: YongQi Mu, Yu-Hua Ji, Mathai Mammen, Eric Stangeland
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20060205784
    Abstract: The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 14, 2006
    Inventors: YongQi Mu, Yu-Hua Ji, Mathai Mammen, Viengkham Malathong
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20060205778
    Abstract: The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 14, 2006
    Inventors: YongQi Mu, Yu-Hua Ji, Mathai Mammen, Viengkham Malathong
  • Calcium channel drugs and uses
    Patent number: 7101909
    Abstract: Novel multibinding compounds are disclosed. The compounds of this invention comprise 2–10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca++ channel, thereby modulating the biological activities thereof.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: September 5, 2006
    Assignee: Theravance, Inc.
    Inventors: Yu-Hua Ji, Maya Natarajan, John H. Griffin, Thomas E. Jenkins
  • Diphenylmethyl compounds useful as muscarinic receptor antagonists
    Patent number: 7071224
    Abstract: This invention provides compounds of formula I: wherein a, b, c, e, m, R1, R2, R3, R4a, R4b, R5, R6, R7 and R8are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: July 4, 2006
    Assignee: Theravance, Inc.
    Inventors: Mathai Mammen, Yu-Hua Ji, Sarah Dunham, Li Li
  • Diphenylmethyl compounds useful as muscarinic receptor antagonists
    Publication number: 20060122182
    Abstract: This invention provides compounds of formula I: wherein a, b, c, e, m, R1, R2, R3, R4a, R4b, R5, R6, R7 and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: January 23, 2006
    Publication date: June 8, 2006
    Inventors: Mathai Mammen, Yu-Hua Ji, Sarah Dunham, Li Li
  • Protein kinase inhibitors
    Patent number: 7037912
    Abstract: Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or more linking groups. Such compounds are useful for treating diseases or medical disorders mediated by protein kinases.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: May 2, 2006
    Assignee: Theravance, Inc.
    Inventors: John H. Griffin, Yu-Hua Ji, Edmund J. Moran, Jonathan W. Wray
  • Compounds having beta adrenergic receptor agonist and muscarinic receptor antagonist activity
    Publication number: 20060035933
    Abstract: This invention provides compounds of formula I: wherein R1, R2, R4, R5, R6, R7, R8a, R8b, W, a, b, c and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both ?2 adrenergic receptor agonist and muscarinic receptor antagonist activity. Accordingly, such compounds are expected to be useful as therapeutic agents for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
    Type: Application
    Filed: August 15, 2005
    Publication date: February 16, 2006
    Inventors: Mathai Mammen, Trevor Mischki, Adam Hughes, Yu-Hua Ji
  • Crystalline form of a substituted pyrrolidine compound
    Publication number: 20050277688
    Abstract: The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of 2-[(S)-1-(8-methylaminooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide or a solvate thereof. This invention also provides pharmaceutical compositions comprising the salt or prepared using the salt; processes and intermediates for preparing the salt; and methods of using the salt to treat a pulmonary disorder.
    Type: Application
    Filed: June 9, 2005
    Publication date: December 15, 2005
    Inventors: Li Li, Robert Chao, Adam Hughes, Yu-Hua Ji, Davar Khossravi, Weijiang Zhang
  • Protein kinase inhibitors
    Publication number: 20050261318
    Abstract: Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or more linking groups. Such compounds are useful for treating diseases or medical disorders mediated by protein kinases.
    Type: Application
    Filed: July 11, 2005
    Publication date: November 24, 2005
    Inventors: John Griffin, Yu-Hua Ji, Edmund Moran, Jonathan Wray
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20050203131
    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: March 10, 2005
    Publication date: September 15, 2005
    Applicant: Theravance, Inc.
    Inventors: Mathai Mammen, Yu-Hua Ji, YongQi Mu, Eric Stangeland, Aaron Kushner, Craig Husfeld
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Publication number: 20050203139
    Abstract: This invention provides compounds of formula I: wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: March 10, 2005
    Publication date: September 15, 2005
    Inventors: Mathai Mammen, Yu-Hua Ji, YongQi Mu, Trevor Mischki, Viengkham Malathong