Abstract: Provided herein are tetravalent antibodies that specifically bind to human PSGL-1. Unlike bivalent antibodies, these tetravalent antibodies contain a dimer of two monomers, with each monomer comprising two light chain variable (VL) domains and two heavy chain variable (VH) domains. This format allows for cross-linker/FcR-expressing cell-independent tetravalent antibodies against PSGL-1 that show enhanced efficacy as compared to bivalent PSGL-1 antibodies. These tetravalent antibodies can be used in a variety of diagnostic and therapeutic methods, including without limitation treating T-cell mediated inflammatory diseases, transplantations, and transfusions.

Abstract: A hand tool includes a plate-like body having a connection end from which a handle is integrally connected there which includes a first section and a second section. A grip is connected to the second section. The first section extends from the connection end by an upward angle and the second section integrally extends from the first section by an angle and toward opposite to the connection end. Each of the first and second sections includes a wall which is a curved wall and faces downward. The hand tool is punched from a metal board and includes a plate-like body and an extension portion which is then bent to form the handle and a grip is connected to the handle.

Abstract: A hand tool includes a plate-like body having a connection end from which a handle is integrally connected there which includes a first section and a second section. A grip is connected to the second section. The first section extends from the connection end by an upward angle and the second section integrally extends from the first section by an angle and toward opposite to the connection end. Each of the first and second sections includes a wall which is a curved wall and faces downward. The hand tool is punched from a metal board and includes a plate-like body and an extension portion which is then bent to form the handle and a grip is connected to the handle.