Patents by Inventor Yu Ishige
Yu Ishige has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11852571Abstract: A sample separation device to introduce a sample to be separated to an inside of the sample separation device, centrifuge the sample, and collect a desired liquid after separation, includes: a sample introducing portion introducing the sample into the sample separation device; a liquid surface defining portion connected to the sample introducing portion; a first separating portion connected to the liquid surface defining portion; a second separating portion connected to the first separating portion; a third separating portion connected to the second separating portion; and a liquid extracting portion including the third separating portion and connected to the third separating portion, in which a tubular flow path is formed by at least the first separating portion and the second separating portion, in which an opening of the sample introducing portion and an opening of the liquid extracting portion are oriented in the same direction.Type: GrantFiled: November 2, 2018Date of Patent: December 26, 2023Assignee: HITACHI, LTD.Inventors: Yu Ishige, Sakuichiro Adachi, Takahiro Ando
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Patent number: 11435373Abstract: An automated analyzer includes a plurality of measurement units including a measurement section which measures a sample, a suction container connected to the plurality of measurement units through a first path, a vacuum exhaust system connected to the suction container through a second path, a discharge section connected to the suction container through a third path, a pressure adjustment mechanism disposed in the second path, and a control section which performs control such that the suction container is vacuum-exhausted by the vacuum exhaust system.Type: GrantFiled: October 6, 2017Date of Patent: September 6, 2022Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Satoshi Ozawa, Kunio Harada, Atsushi Kishioka, Haruyoshi Yamamoto, Yu Ishige, Yoshinobu Kohara, Tetsuyoshi Ono
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Patent number: 11397162Abstract: There is provided an electrolyte measuring device that can decrease a liquid amount used for measurement, in which stable sealing can be provided in connecting passages of ion selective electrodes to each other with no gap, while maintaining high measurement accuracy of an existing ion selective electrode, and a residing sample liquid can be greatly decreased. In a flow-type ion selective electrode, a sealing member is used, which can be brought into intimate contact with a passage connecting unit to near a passage hole. A gap regulating member is provided to keep a gap between the electrodes constant and to prevent the sealing member from being excessively pressed. An electrode case has a structure suitable for the sealing member for allowing the alignment and holding of the sealing member.Type: GrantFiled: September 28, 2020Date of Patent: July 26, 2022Assignee: Hitachi High-Tech CorporationInventors: Atsushi Kishioka, Yu Ishige, Tetsuyoshi Ono
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Publication number: 20210132096Abstract: An automated analyzer includes a plurality of measurement units including a measurement section which measures a sample, a suction container connected to the plurality of measurement units through a first path, a vacuum exhaust system connected to the suction container through a second path, a discharge section connected to the suction container through a third path, a pressure adjustment mechanism disposed in the second path, and a control section which performs control such that the suction container is vacuum-exhausted by the vacuum exhaust system.Type: ApplicationFiled: October 6, 2017Publication date: May 6, 2021Inventors: Satoshi OZAWA, Kunio HARADA, Atsushi KISHIOKA, Haruyoshi YAMAMOTO, Yu ISHIGE, Yoshinobu KOHARA, Tetsuyoshi ONO
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Publication number: 20210010970Abstract: There is provided an electrolyte measuring device that can decrease a liquid amount used for measurement, in which stable sealing can be provided in connecting passages of ion selective electrodes to each other with no gap, while maintaining high measurement accuracy of an existing ion selective electrode, and a residing sample liquid can be greatly decreased. In a flow-type ion selective electrode, a sealing member is used, which can be brought into intimate contact with a passage connecting unit to near a passage hole. A gap regulating member is provided to keep a gap between the electrodes constant and to prevent the sealing member from being excessively pressed. An electrode case has a structure suitable for the sealing member for allowing the alignment and holding of the sealing member.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Inventors: Atsushi KISHIOKA, Yu Ishige, Tetsuyoshi Ono
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Patent number: 10871464Abstract: There is provided a solid-contact ion-selective electrode having a high potential stability and potential reproducibility. The ion-selective electrode includes an ion sensitive film having a Group-1 element ion, a Group-2 element ion, a hydronium ion or an ammonium ion as a target ion, an ion occluding material layer, and a conductive electrode, wherein the ion occluding material contained in the ion occludes material layer occluding the target ion, the ion occluding material being a Prussian blue analog represented by the structure formula AaMx[M?(CN)6]y?z.kH2O. Herein, A is one type or a plurality of types of Group-1 elements, Group-2 elements, hydronium, or ammonium; M and M? are one type or a plurality of types of transition metals; M or M? includes at least one of nickel, cobalt, copper, silver, and cadmium; ? is a vacancy in a porous coordination polymer; x and y are greater than zero; and a, z, and k are numbers equal to or greater than zero.Type: GrantFiled: August 30, 2016Date of Patent: December 22, 2020Assignee: Hitachi High-Tech CorporationInventors: Yu Ishige, Wolfgang Schuhmann, Stefan Klink
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Publication number: 20200355585Abstract: A sample separation device to introduce a sample to be separated to an inside of the sample separation device, centrifuge the sample, and collect a desired liquid after separation, includes: a sample introducing portion introducing the sample into the sample separation device; a liquid surface defining portion connected to the sample introducing portion; a first separating portion connected to the liquid surface defining portion; a second separating portion connected to the first separating portion; a third separating portion connected to the second separating portion; and a liquid extracting portion including the third separating portion and connected to the third separating portion, in which a tubular flow path is formed by at least the first separating portion and the second separating portion, in which an opening of the sample introducing portion and an opening of the liquid extracting portion are oriented in the same direction.Type: ApplicationFiled: November 2, 2018Publication date: November 12, 2020Inventors: Yu ISHIGE, Sakuichiro ADACHI, Takahiro ANDO
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Patent number: 10823695Abstract: There is provided an electrolyte measuring device that can decrease a liquid amount used for measurement, in which stable sealing can be provided in connecting passages of ion selective electrodes to each other with no gap, while maintaining high measurement accuracy of an existing ion selective electrode, and a residing sample liquid can be greatly decreased. In a flow-type ion selective electrode, a sealing member is used, which can be brought into intimate contact with a passage connecting unit to near a passage hole. A gap regulating member is provided to keep a gap between the electrodes constant and to prevent the sealing member from being excessively pressed. An electrode case has a structure suitable for the sealing member for allowing the alignment and holding of the sealing member.Type: GrantFiled: January 22, 2015Date of Patent: November 3, 2020Assignee: Hitachi High-Technologies CorporationInventors: Atsushi Kishioka, Yu Ishige, Tetsuyoshi Ono
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Publication number: 20180298435Abstract: The present invention was made to provide novel methods for detecting DNA and devices therefor. Specifically, the present invention is a method of detecting DNA including the steps of: adding, to an oil, a fluorescently-labeled probe, a DNA intercalator, and a DNA solution containing a target DNA to produce droplets; performing PCR on the droplets; and measuring fluorescence from the fluorescently-labeled probe and fluorescence from the DNA intercalator, wherein the DNA solution has a concentration at which each droplet is produced so as to contain one or less target DNA molecule. In addition, the present invention is a DNA detection device including a droplet production unit, a thermal cycler unit, and a fluorescence detection unit which perform these steps.Type: ApplicationFiled: July 5, 2016Publication date: October 18, 2018Inventors: Junko TANAKA, Yoshinobu KOHARA, Kunio HARADA, Yu ISHIGE
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Publication number: 20180246054Abstract: There is provided a solid-contact ion-selective electrode having a high potential stability and potential reproducibility. The ion-selective electrode includes an ion sensitive film having a Group-1 element ion, a Group-2 element ion, a hydronium ion or an ammonium ion as a target ion, an ion occluding material layer, and a conductive electrode, wherein the ion occluding material contained in the ion occludes material layer occluding the target ion, the ion occluding material being a Prussian blue analog represented by the structure formula AaMx[M?(CN)6]y?z.kH20. Herein, A is one type or a plurality of types of Group-1 elements, Group-2 elements, hydronium, or ammonium; M and M? are one type or a plurality of types of transition metals; M or M? includes at least one of nickel, cobalt, copper, silver, and cadmium; ? is a vacancy in a porous coordination polymer; x and y are greater than zero; and a, z, and k are numbers equal to or greater than zero.Type: ApplicationFiled: August 30, 2016Publication date: August 30, 2018Inventors: Yu ISHIGE, Wolfgang SCHUHMANN, Stefan KLINK
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Patent number: 10018585Abstract: An electrolyte concentration measuring apparatus is provided with: a plurality of ion selective electrodes and one reference electrode; a sample introduction unit that introduces a sample solution to the plurality of ion selective electrodes and the reference electrode; a potential measuring unit that measures a voltage between the plurality of ion selective electrodes and the reference electrode; and a resistance measuring unit that measures a direct-current resistance of the plurality of ion selective electrodes.Type: GrantFiled: April 10, 2014Date of Patent: July 10, 2018Assignee: Hitachi High-Technologies CorporationInventors: Yu Ishige, Masao Kamahori, Atsushi Kishioka, Tetsuyoshi Ono, Masafumi Miyake
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Patent number: 9885683Abstract: To enhance the potential stability of a solid-electrode-type ion-selective electrode and reduce individual variations, the present invention is provided with an ion-sensitive membrane adapted to be in contact with a measurement solution, a mixture of graphite and liquid oil that is in contact with the ion-sensitive membrane, and a conductor that is in contact with the mixture of graphite and liquid oil.Type: GrantFiled: July 28, 2014Date of Patent: February 6, 2018Assignee: Hitachi High-Technologies CorporationInventors: Yu Ishige, Masao Kamahori, Tetsuyoshi Ono, Yusuke Goto
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Patent number: 9658153Abstract: To prevent lowering of sensitivity of a flow cell based on total reflection of light at an outer face of a glass capillary at a joint part with a pipe, the flow cell includes, at joint parts with a pipe 605 to introduce solution to a glass capillary 601 and with a pipe to discharge solution from the capillary, an inorganic material layer 602 that reflects measurement light to modify the outer face of the glass capillary as well as a reinforcement layer 711 to modify the surface thereof.Type: GrantFiled: October 30, 2012Date of Patent: May 23, 2017Assignee: Hitachi High-Technologies CorporationInventors: Yusuke Goto, Masao Kamahori, Yu Ishige, Hiroshi Sasaki, Hideyuki Akiyama, Shintaro Kubo
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Publication number: 20160334358Abstract: There is provided an electrolyte measuring device that can decrease a liquid amount used for measurement, in which stable sealing can be provided in connecting passages of ion selective electrodes to each other with no gap, while maintaining high measurement accuracy of an existing ion selective electrode, and a residing sample liquid can be greatly decreased. In a flow-type ion selective electrode, a sealing member is used, which can be brought into intimate contact with a passage connecting unit to near a passage hole. A gap regulating member is provided to keep a gap between the electrodes constant and to prevent the sealing member from being excessively pressed. An electrode case has a structure suitable for the sealing member for allowing the alignment and holding of the sealing member.Type: ApplicationFiled: January 22, 2015Publication date: November 17, 2016Inventors: Atsushi KISHIOKA, Yu ISHIGE, Tetsuyoshi ONO
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Publication number: 20160223486Abstract: To enhance the potential stability of a solid-electrode-type ion-selective electrode and reduce individual variations, the present invention is provided with an ion-sensitive membrane adapted to be in contact with a measurement solution, a mixture of graphite and liquid oil that is in contact with the ion-sensitive membrane, and a conductor that is in contact with the mixture of graphite and liquid oil.Type: ApplicationFiled: July 28, 2014Publication date: August 4, 2016Inventors: Yu ISHIGE, Masao KAMAHORI, Tetsuyoshi ONO, Yusuke GOTO
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Publication number: 20160054257Abstract: An electrolyte concentration measuring apparatus is provided with: a plurality of ion selective electrodes and one reference electrode; a sample introduction unit that introduces a sample solution to the plurality of ion selective electrodes and the reference electrode; a potential measuring unit that measures a voltage between the plurality of ion selective electrodes and the reference electrode; and a resistance measuring unit that measures a direct-current resistance of the plurality of ion selective electrodes.Type: ApplicationFiled: April 10, 2014Publication date: February 25, 2016Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Yu ISHIGE, Masao KAMAHORI, Atsushi KISHIOKA, Tetsuyoshi ONO, Masafumi MIYAKE
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Publication number: 20140332674Abstract: To prevent lowering of sensitivity of a flow cell based on total reflection of light at an outer face of a glass capillary at a joint part with a pipe, the flow cell includes, at joint parts with a pipe 605 to introduce solution to a glass capillary 601 and with a pipe to discharge solution from the capillary, an inorganic material layer 602 that reflects measurement light to modify the outer face of the glass capillary as well as a reinforcement layer 711 to modify the surface thereof.Type: ApplicationFiled: October 30, 2012Publication date: November 13, 2014Inventors: Yusuke Goto, Masao Kamahori, Yu Ishige, Hiroshi Sasaki, Hideyuki Akiyama, Shintaro Kubo
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Patent number: 8712701Abstract: Provided is a potentiometric sensor chip in which the positional relationship among a reference electrode, a measurement electrode, and a sample inlet which enables measurement from the start of a reaction is defined, and further provided is a method for detecting the start time of the reaction. A very small amount of sample is measured with high accuracy. The very small quantity of sample is measured by a rate assay. When a reference electrode (103) is disposed between a sample inlet (102) and a measurement electrode (104), a sample solution arrives at the reference electrode (103) earlier than at the measurement electrode (104), whereby the surface potential of the measurement electrode (104) can be measured simultaneously when the sample solution arrives at the measurement electrode (104) and dissolves a reagent and thereby a reaction starts.Type: GrantFiled: October 29, 2009Date of Patent: April 29, 2014Assignee: Hitachi, Ltd.Inventors: Yu Ishige, Masao Kamahori, Kuniaki Nagamine
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Patent number: 8702933Abstract: A potentiometric sensor with suppressed leak current on the surface of an electrode and improved for a dynamic range and a response speed, in which a redox compound is immobilized through insulative molecules on the surface of a gold electrode, and a current between a source and drain of an insulated gate field-effect transistor along with reaction between an oxidized substance or a reduced substance produced by the reaction of a measured substance in a sample solution injector for supplying the sample solution containing the measured substance and an enzyme and a redox compound on the surface of the gold electrode, is monitored on real time to measure the change of the surface potential.Type: GrantFiled: June 14, 2012Date of Patent: April 22, 2014Assignee: Hitachi, Ltd.Inventors: Yu Ishige, Masao Kamahori
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Publication number: 20130274126Abstract: Provided is a device that can detect cells or bacteria in units of a single cell or bacterium, and can further measure the amounts of activity of cells or bacteria or responses of the cells or bacteria to drugs in units of a single cell or bacterium. A plurality of partitioned regions each having about the same size as a cell or a bacterium is provided, and a plurality of types of electrical sensors 201 and 202 are arranged in each partitioned region.Type: ApplicationFiled: March 14, 2013Publication date: October 17, 2013Applicant: HITACHI, LTD.Inventors: Yu ISHIGE, Masao KAMAHORI