Abstract: Disclosed herein an isolated neutralizing antibody, which is capable of specifically binding to chitinase-3-like protein-1 (YKL-40) and uses thereof. The neutralizing antibody can further conjugate with a metal chelator to form an antibody complex. Further, labeling the antibody complex with a radioactive metal nuclide results in formation of a radioactive antibody complex, which can be used as a contrast agent and treatment for YKL-40 over-expression-related diseases. The radioactive antibody complex can specifically bind to YKL-40, and can be used for diagnosis and the preparation of the use of the treatment for cancers related to YKL-40 over-expression.

Abstract: A novel fibrous membrane comprises at least one substrate layer comprising at least 80% by weight of microfibers that carry positively charged and/or negatively charged functional groups, and at least one layer of filtration material attached to the substrate layer, wherein the layer of filtration material comprises at least 80% by weight of nanofibers that carry negatively charged and/or positively charged functional groups. The fibrous membrane is able to remove or reduce the concentration of bacteria, viruses and heavy metals while maintaining relatively high water flow. A filter comprising the fibrous membrane and a method for manufacturing the fibrous membrane are also provided.

Abstract: A novel fibrous membrane comprises at least one substrate layer comprising at least 80% by weight of microfibers that carry positively charged and/or negatively charged functional groups, and at least one layer of filtration material attached to the substrate layer, wherein the layer of filtration material comprises at least 80% by weight of nanofibers that carry negatively charged and/or positively charged functional groups. The fibrous membrane is able to remove or reduce the concentration of bacteria, viruses and heavy metals while maintaining relatively high water flow. A filter comprising the fibrous membrane and a method for manufacturing the fibrous membrane are also provided.