Abstract: The present disclosure includes cationic carrier units comprising (i) a water-soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

Abstract: The present disclosure includes cationic carrier units comprising (i) a water soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moeity, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an RNA and/or DNA) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

Abstract: A biodegradable resin composition and a method for making the biodegradable resin composition are disclosed. The biodegradable resin composition has improved biodegradability by including polyethylene, a biodegradable resin, and polybutylene adipate terephthalate (PBAT).

Abstract: A biodegradable resin composition and a method for producing the biodegradable resin composition are disclosed. The biodegradable resin includes three components, polyethylene, a biodegradable resin, and at least one selected from polybutylene adipate terephthalate and maleic anhydride copolymer, thereby providing excellent compatibility and mechanical properties.

Abstract: The present invention relates to a high-density ethylene-based polymer and a pipe using the same, the high-density ethylene-based polymer including: an ethylene homopolymer; or a copolymer of ethylene and at least one comonomer selected from the group consisting of an ?-olefin, a cyclic olefin and linear, branched and cyclic dienes. The pipe using the high-density ethylene-based polymer of the present invention has more superior strain hardening than a conventional polyethylene resin pipe, and thus has excellent long-term pressure resistance characteristics and processability.

Abstract: The invention relates to: a hybrid supported metallocene catalyst includes at least one first metallocene compound among the compounds represented by chemical formula 1, at least one second metallocene compound among the compounds represented by chemical formula 2 and a cocatalyst compound; a method for preparing an ethylene-?-olefin copolymer, comprising polymerizing olefin monomers in the presence thereof; and an ethylene-?-olefin copolymer having improved melt strength.

Abstract: Provided are an ethylene-based polymer having excellent long-term pressure resistance characteristics and a pipe using the ethylene-based polymer. The ethylene-based polymer satisfies the balance of mechanical characteristics and excellent molding processability, as compared with a conventional ethylene-based polymer. Also provided are an ethylene-based polymer having a wide molecular weight distribution and a small lamellar thickness, thereby increasing tie molecules and obtaining excellent long-term pressure resistance characteristics, and a pipe using the same.

Abstract: The present invention relates to a high-density ethylene-based polymer and a pipe using the same, the high-density ethylene-based polymer including: an ethylene homopolymer; or a copolymer of ethylene and at least one comonomer selected from the group consisting of an ?-olefin, a cyclic olefin and linear, branched and cyclic dienes. The pipe using the high-density ethylene-based polymer of the present invention has more superior strain hardening than a conventional polyethylene resin pipe, and thus has excellent long-term pressure resistance characteristics and processability.

Abstract: The invention relates to: a hybrid supported metallocene catalyst includes at least one first metallocene compound among the compounds represented by chemical formula 1, at least one second metallocene compound among the compounds represented by chemical formula 2 and a cocatalyst compound; a method for preparing an ethylene-?-olefin copolymer, comprising polymerizing olefin monomers in the presence thereof; and an ethylene-?-olefin copolymer having improved melt strength.