Abstract: The present disclosure includes cationic carrier units comprising (i) a water soluble polymer, (ii) a positively charged carrier, and (iii) an adjuvant moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

Abstract: The present disclosure includes cationic carrier units comprising (i) a water-soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

Abstract: The present disclosure includes cationic carrier units comprising (i) a water soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moeity, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an RNA and/or DNA) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

Abstract: A system for analyzing a solid-state battery and a lithium rechargeable battery such as a lithium ion battery, and an analysis method using the system are proposed. The analysis system for a lithium secondary battery includes a housing having an accommodation space therein, and a lithium secondary battery accommodated in the accommodation space of the housing and being chargeable and dischargeable, in which the lithium secondary battery includes: an electrolyte part. The system also includes a first electrode part positioned on a side of the electrolyte part, and a second electrode part positioned on another side of the electrolyte part, in which the electrolyte part includes a matrix including a solid electrolyte having conductivity for lithium ions, one or more reference electrodes inserted in the matrix, and one or more SoC adjusters inserted in the matrix at a predetermined distance in a width direction from the reference electrode.

Abstract: Disclosed are an all-solid-state battery including symmetrically arranged reference electrodes, a device for manufacturing the same, and a method of manufacturing using same.

Abstract: The present disclosure relates to an all-solid-state battery analysis system capable of reliably obtaining an electrochemical signal according to the degree of charge of an electrode, and an all-solid-state battery analysis method using the same. The system may include a body member, of cylindrical shape, having a first cavity extending therethrough in a vertical direction and a second cavity extending therethrough in a horizontal direction and communicating with the first cavity. The system may include a first conductive member including a first base having a plate shape and a first protrusion protruding from the first base having a shape corresponding to a shape of the first cavity; and a second conductive member including a second base having a plate shape and a second protrusion protruding from the second base and having a shape corresponding to the shape of the first cavity.