Patents by Inventor Yu-Jie Huang

Yu-Jie Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10533966
    Abstract: Various bioFET sensor readout circuits and their methods of operation are described. A readout circuit includes a plurality of logic gates coupled in cascade, a delay extractor, and a counting module. Each logic gate of the plurality of logic gates includes at least one bioFET sensor. The delay extractor is designed to generate a pulse-width signal based on a time difference between an output signal from the plurality of logic gates and a reference signal. The counting module is designed to receive the pulse-width signal and output a digital count corresponding to a width of the pulse-width signal.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: January 14, 2020
    Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Yu-Jie Huang, Jui-Cheng Huang
  • Patent number: 10502707
    Abstract: A microfluidic system includes a semiconductor substrate having a first surface and an opposite, parallel second surface, a first bioFET sensor and a second bioFET sensor. An isolation layer is disposed on the second surface of the semiconductor substrate and has a first opening over the first bioFET sensor and a second opening over the second bioFET sensor. An interface layer is disposed in at least each of the first opening and the second opening. The system includes a readout circuit having a differential amplifier designed to measure a difference between signals associated with the first bioFET sensor and the second bioFET sensor. The system also includes a microfluidic network designed to deliver fluid to the interface layer disposed in each of the first opening and the second opening.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: December 10, 2019
    Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Allen Timothy Chang, Jui-Cheng Huang, Tung-Tsun Chen, Yu-Jie Huang, Penny Hsiao
  • Publication number: 20190369044
    Abstract: A microfluidic system includes a semiconductor substrate having a first surface and an opposite, parallel second surface, a first bioFET sensor and a second bioFET sensor. An isolation layer is disposed on the second surface of the semiconductor substrate and has a first opening over the first bioFET sensor and a second opening over the second bioFET sensor. An interface layer is disposed in at least each of the first opening and the second opening. The system includes a readout circuit having a differential amplifier designed to measure a difference between signals associated with the first bioFET sensor and the second bioFET sensor. The system also includes a microfluidic network designed to deliver fluid to the interface layer disposed in each of the first opening and the second opening.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 5, 2019
    Applicant: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Allen Timothy Chang, Jui-Cheng Huang, Tung-Tsun Chen, Yu-Jie Huang, Penny Hsiao
  • Publication number: 20190145927
    Abstract: A biologically sensitive field effect transistor includes a substrate, a first control gate and a second control gate. The substrate has a first side and a second side opposite to the first side, a source region and a drain region. The first control gate is disposed on the first side of the substrate. The second control gate is disposed on the second side of the substrate. The second control gate includes a sensing film disposed on the second side of the substrate. A voltage biasing between the source region and the second control gate is smaller than a threshold voltage of the second control gate.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 16, 2019
    Applicant: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Yu-Jie HUANG, Jui-Cheng Huang, Cheng-Hsiang Hsieh
  • Publication number: 20190033251
    Abstract: Various bioFET sensor readout circuits and their methods of operation are described. A readout circuit includes a plurality of logic gates coupled in cascade, a delay extractor, and a counting module. Each logic gate of the plurality of logic gates includes at least one bioFET sensor. The delay extractor is designed to generate a pulse-width signal based on a time difference between an output signal from the plurality of logic gates and a reference signal. The counting module is designed to receive the pulse-width signal and output a digital count corresponding to a width of the pulse-width signal.
    Type: Application
    Filed: July 27, 2017
    Publication date: January 31, 2019
    Inventors: Yu-Jie HUANG, Jui-Cheng Huang
  • Publication number: 20190033252
    Abstract: A bioFET device includes a semiconductor substrate having a first surface and an opposite, parallel second surface and a plurality of bioFET sensors on the semiconductor substrate. Each of the bioFET sensors includes a gate formed on the first surface of the semiconductor substrate and a channel region formed within the semiconductor substrate beneath the gate and between source/drain (S/D) regions in the semiconductor substrate. The channel region includes a portion of the second surface of the semiconductor substrate. An isolation layer is disposed on the second surface of the semiconductor substrate. The isolation layer has an opening positioned over the channel region of more than one bioFET sensor of the plurality of bioFET sensors. An interface layer is disposed on the channel region of the more than one bioFET sensor in the opening.
    Type: Application
    Filed: July 27, 2017
    Publication date: January 31, 2019
    Inventors: Jui-Cheng HUANG, Yi-Hsien CHANG, Chin-Hua WEN, Chun-Ren CHENG, Shih-Fen HUANG, Tung-Tsun CHEN, Yu-Jie HUANG, Ching-Hui LIN, Sean CHENG, Hector CHANG
  • Publication number: 20190004027
    Abstract: A semiconductor device includes a circuit layer and a nanopore layer. The nanopore layer is formed on the circuit layer and is formed with a pore therethrough. The circuit layer includes a circuit unit configured to drive a biomolecule through the pore and to detect a current associated with a resistance of the nanopore layer, whereby a characteristic of the biomolecule can be determined using the currents detected by the circuit unit.
    Type: Application
    Filed: May 31, 2018
    Publication date: January 3, 2019
    Inventors: Kun-Lung Chen, Tung-Tsun Chen, Cheng-Hsiang Hsieh, Yu-Jie Huang, Jui-Cheng Huang
  • Patent number: 10161901
    Abstract: A biologically sensitive field effect transistor includes a substrate, a first control gate and a second control gate. The substrate has a first side and a second side opposite to the first side, a source region and a drain region. The first control gate is disposed on the first side of the substrate. The second control gate is disposed on the second side of the substrate. The second control gate includes a sensing film disposed on the second side of the substrate. A voltage biasing between the source region and the second control gate is smaller than a threshold voltage of the second control gate.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: December 25, 2018
    Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Yu-Jie Huang, Jui-Cheng Huang, Cheng-Hsiang Hsieh
  • Publication number: 20180203006
    Abstract: A fluidic cartridge and methods of operation are described. The fluidic cartridge includes a substrate having a plurality of contact pads designed to electrically couple with an analyzer, a semiconductor chip having a sensor array, and a reference electrode. The fluidic cartridge includes a first fluidic channel having an inlet and coupled to a second fluidic channel, the second fluidic channel being aligned such that the sensor array and the reference electrode are disposed within the second fluidic channel. A first plug is disposed at the first inlet. The first plug includes a compliant material configured to be punctured by a capillary without leaking fluid through the first plug.
    Type: Application
    Filed: January 13, 2017
    Publication date: July 19, 2018
    Inventors: JUI-CHENG HUANG, CHIN-HUA WEN, TUNG-TSUN CHEN, CHENG-HSIANG HSIEH, YU-JIE HUANG, CHING-HUI LIN
  • Publication number: 20170160226
    Abstract: A biologically sensitive field effect transistor includes a substrate, a first control gate and a second control gate. The substrate has a first side and a second side opposite to the first side, a source region and a drain region. The first control gate is disposed on the first side of the substrate. The second control gate is disposed on the second side of the substrate. The second control gate includes a sensing film disposed on the second side of the substrate. A voltage biasing between the source region and the second control gate is smaller than a threshold voltage of the second control gate.
    Type: Application
    Filed: December 7, 2015
    Publication date: June 8, 2017
    Inventors: Yu-Jie HUANG, Jui-Cheng HUANG, Cheng-Hsiang HSIEH
  • Publication number: 20130334578
    Abstract: A molecule sensor included in a molecule sensor device has a semiconductor substrate, a bottom gate, a source portion, a drain portion, and a nano-scale semiconductor wire. The bottom gate is for example a poly-silicon layer formed on the semiconductor substrate and electrically insulated from the semiconductor substrate. The source portion is formed on the semiconductor substrate and insulated from the semiconductor substrate. The drain portion is formed on the semiconductor substrate and insulated from the semiconductor substrate. The nano-scale semiconductor wire is connected between the source portion and the drain portion, formed on the bottom gate, insulated from the bottom gate, and has a decoration layer thereon for capturing a molecular. The source portion, drain portion, and nano-wire semiconductor wire are for example another poly-silicon layer. The bottom gate receives a specified voltage to change an amount of surface charge carriers of the nano-scale semiconductor wire.
    Type: Application
    Filed: April 25, 2013
    Publication date: December 19, 2013
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: CHE-WEI HUANG, YU-JIE HUANG, PEI-WEN YEN, HSIAO-TING HSUEH, SHEY-SHI LU, CHIH-TING LIN
  • Publication number: 20130274665
    Abstract: A drug-delivery chip and a method of fabricating the same are provided. The drug-delivery chip has a main body having at least one drug receiving space individually formed with an opening for storing drugs therein; a thin film for sealing up the at least one drug receiving space; a first conductive wire connecting to one end of the thin film; a second conductive wire connecting to another end of the thin film; a signal-receiving module for receiving actuated signals; and a control module for applying voltages to first and second wire conductive s according to the actuated signal, thereby generating heat to break off the thin film for the release of a drug or drugs received in the at least one drug receiving space.
    Type: Application
    Filed: June 10, 2013
    Publication date: October 17, 2013
    Inventors: Shey-Shi Lu, Yao-Joe Yang, Yu-Jie Huang, Chii-Wann Lin, Hsin-Hung Liao, Tao Wang, Pen-Li Huang, Yao-Hong Wang
  • Patent number: 8460564
    Abstract: A drug-delivery chip and a method of fabricating the same are provided. The drug-delivery chip has a main body having at least one drug receiving space individually formed with an opening for storing drugs therein; a thin film for sealing up the at least one drug receiving space; a first conductive wire connecting to one end of the thin film; a second conductive wire connecting to another end of the thin film; a signal-receiving module for receiving actuated signals; and a control module for applying voltages to first and second wire conductive s according to the actuated signal, thereby generating heat to break off the thin film for the release of a drug or drugs received in the at least one drug receiving space.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: June 11, 2013
    Assignee: National Taiwan University
    Inventors: Shey-Shi Lu, Yao-Joe Yang, Yu-Jie Huang, Chii-Wann Lin, Hsin-Hung Liao, Tao Wang, Pen-Li Huang, Yao-Hong Wang
  • Publication number: 20100312229
    Abstract: A drug-delivery chip and a method of fabricating the same are provided. The drug-delivery chip has a main body having at least one drug receiving space individually formed with an opening for storing drugs therein; a thin film for sealing up the at least one drug receiving space; a first conductive wire connecting to one end of the thin film; a second conductive wire connecting to another end of the thin film; a signal-receiving module for receiving actuated signals; and a control module for applying voltages to first and second wire conductive s according to the actuated signal, thereby generating heat to break off the thin film for the release of a drug or drugs received in the at least one drug receiving space.
    Type: Application
    Filed: January 28, 2010
    Publication date: December 9, 2010
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: Shey-Shi Lu, Yao-Joe Yang, Yu-Jie Huang, Chii-Wann Lin, Hsin-Hung Liao, Tao Wang, Pen-Li Huang, Yao-Hong Wang
  • Publication number: 20090267759
    Abstract: A method for controlling a wireless smart display panel. The method uses a sensor to monitor environmental information, such as temperature or humidity, and the information is transmitted to a processor by using a wireless communication device that is compatible with IEEE 802.15.4. Moreover, the environmental information is converted to image information and displayed on a display device through the processor. Consequently, users understand outward environmental information in time.
    Type: Application
    Filed: July 30, 2008
    Publication date: October 29, 2009
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: Shey-Shy LU, Yu-Jie Huang, Tse-Yuan Chen, Shun-Yang Ko