Abstract: The present invention provides compositions and methods comprising conjugates with a polymeric backbone, e.g., polyvinyl alcohol (PVA), covalently linked histone deacetylase (HDAC) inhibitors, such as butyrate or propionate, and covalently linked retinoids, such as all-trans retinoic acid (RA). The methods and compositions of the invention are useful for the treatment or prevention of cancer or metabolic diseases in tissues such as the colon or liver.

Abstract: The invention provides methods and pharmaceutical compositions for treating a metabolic disease in a subject. In some aspects, the invention comprises administering to the subject a therapeutically effective amount of a miR-22 inhibitor. In some embodiments, the invention further comprises administering to the subject a metabolism-enhancing agent such as a miR-22 inducer.

Abstract: The invention provides methods and pharmaceutical compositions for treating cancer or a metabolic disease in a subject. In some aspects, the invention comprises administering to the subject a therapeutically effective amount of a retinoid and a histone deacetylase (HDAC) inhibitor. In some embodiments, the HDAC inhibitor is a short-chain fatty acid and/or suberanilohydroxamic acid (SAHA). In other aspects, the invention comprises administering to the subject a therapeutically effective amount of a microRNA. Pharmaceutical compositions and kits for treating a subject with cancer or a metabolic disease are also provided herein.