Patents by Inventor Yu L. Kong

Yu L. Kong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biologically active compounds isolated from aerobic fermentation of Trichoderma viride
    Patent number: 5364948
    Abstract: This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compounds are also potent antifungal agents. Additionally, they inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras and are thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: November 15, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Guy H. Harris, Deborah Zink, E. Tracy T. Jones, Yu L. Kong
  • Process for the production of a novel endothelin antagonist
    Patent number: 5352800
    Abstract: Fermentation processes for the production of a compound of the Structural Formula I ##STR1## The compound of Structural Formula I has been shown to have endothelin antagonist activity and is therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure vasospasm, cerebral and cardia ischemia, myocardial infarction inflammatory diseases, Raynaud's disease, endotoxin shock and asthma.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: October 4, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Gerard F. Bills, Michael A. Goetz, Robert A. Giacobbe, Lucia Herranz, E. Tracy Turner Jones, Fernando Pelaez, Yu L. Kong, Sheo B. Singh, Siobhan Stevens-Miles
  • Anthelmintic milbemycin analogs of novel microorganisms
    Patent number: 5290804
    Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of microorganisms identified as MA-6825, MA-6864 and MA-6865. The structure of the novel compounds isolated from the microorganisms is presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents and are related to the class of macrolides known as milbemycins. Compositions for such uses are also disclosed.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: March 1, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert T. Goegelman, Elvira Munguira, Maria T. Diez Matas, Ruth S. Sykes, Yu L. Kong, Jerrold M. Liesch, Gregory L. Helms, E. Tracy Turner Jones
  • Cholesterol-lowering agents
    Patent number: 5283256
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).
    Type: Grant
    Filed: July 22, 1992
    Date of Patent: February 1, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Claude Dufresne, Josep Guarro, Leeyuan Huang, Yu L. Kong, Russell B. Lingham, Maria S. Meinz, Keith C. Silverman, Sheo B. Singh
  • Substituted hexahydrobenzopyran derivatives as angiotensin II antagonists
    Patent number: 5276054
    Abstract: Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: January 4, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Maria T. Diez, Michael A. Goetz, Robert A. Giacobbe, Otto D. Hensens, Leeyan Huang, Isabel Martin, E. Tracy T. Jones, Siobhan Stevens-Miles, Yu L. Kong
  • Fungal microorganism ATCC 74167 capable of producing cholesterol lowering compounds
    Patent number: 5260215
    Abstract: This invention relates to a fungal microorganism MF5757 (ATCC 74167) isolated from bark discs of Quercus prinus L. (Chestnut Oak) and useful in a fermentation process to form a compound of formula (I): ##STR1## which is a squalene synthetase inhibitor and thus useful as a cholesterol lowering agent.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: November 9, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Wendy H. Clapp, Yu L. Kong, Jon D. Polishook
  • Drug for treating manic depression
    Patent number: 4981980
    Abstract: Fermentation of a nutrient medium by a Hypomycetes fungus of the genus Memnoniella or Stachybotrys yields a product with a major component of structural formula I: ##STR1## which is an inositol monophosphate phosphatase inhibitor and thereby useful in the treatment of manic depression.
    Type: Grant
    Filed: September 14, 1989
    Date of Patent: January 1, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Robert A. Giocobbe, Leeyuan Huang, Yu L. Kong, Yiu-Kuen T. Lam, Sagrario M. Del Val, Carol F. Wichmann, Deborah L. Zink