Abstract: A bispecific antibody and a monoclonal antibody against human thymic stromal lymphopoietin (TSLP), and a use thereof.

Abstract: The present invention relates to methods and compositions for treating an LRRK2-associate disorder or condition, e.g., Parkinson's Disease, methods for reducing or preventing neuronal cell death, and methods for reducing neurodegeneration and/or neuroinflammation, in a subject in need thereof, by an agent that decreases the expression of LRRK2, e.g., an agent that induces LRRK2 mRNA decay.

Abstract: Disclosed in the present application are an antibody or an antigen-binding portion thereof binding to human IL-4R, a polynucleotide encoding the antibody or antigen-binding portion thereof, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or vector, a method for preparing and purifying the antibody, and the use of the antibody or antigen-binding portion thereof.

Abstract: A waterproof protective case for a smart watch, comprising a main body, a transparent cover, a waterproof ring and a bottom cover. The transparent cover is bonded to an opening on top of the main body by glue. Directly bonding with glue not only has the function of installing the transparent cover, but the cured glue forms an apron and has the function of waterproofing. A waterproof ring is additionally arranged on an inner wail surface of the main body, and is combined with the inner wall surface by means of integral inlay molding, which does not need to be installed separately, does not have the problem of falling off The function of the waterproof ring is to press the glass surface of the smart watch to prevent water vapor from seeping into the inside of the watch, so that the protective case can achieve a better waterproof effect.

Abstract: Apparatus and methods are provided for enhanced AM RLC for NB-IoT UE in the NTN. In one novel aspect, the UE is configured with HARQ disabled, and configured with fast polling and/or fast status report for AM RLC enhancement. In one embodiment, the UE is configured with shortened AM window size, and wherein the shortened window size is smaller than an AM window size for an NB-IoT device. In other embodiments, the fast polling is triggered based on PDU threshold or byte threshold, or triggered based on an NTN polling timer, or triggered based on a combination of an NTN polling timer and one or more threshold triggers. In one embodiment, UE is configured to autonomously send a status report when a reception failure of an RLC PDU is detected, and wherein the status report is sent by a semi-persistent scheduling (SPS) uplink resource.

Abstract: The present application provides a bispecific antibody against rabies virus, and an application thereof. The bispecific antibody comprises two antigen-binding fragments binding to different epitopes of G protein of rabies virus, and has rabies virus neutralization activity.

Abstract: A bispecific antibody, which comprises an antigen-binding portion against human CD3E and/or an antigen-binding portion against human BCMA. Additionally, provided are medical and biological uses of the bispecific antibody.

Abstract: Provided is a bispecific antibody comprising an antigen-binding portion for human CD3E and/or an antigen-binding portion for human CD123. Further provided are the medical and biological uses of the bispecific antibody.

Abstract: Disclosed in the present application are an antibody or an antigen-binding portion thereof binding to human IL-4R, a polynucleotide encoding the antibody or antigen-binding portion thereof, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or vector, a method for preparing and purifying the antibody, and the use of the antibody or antigen-binding portion thereof.

Abstract: The present application provides a bispecific antibody against rabies virus, and an application thereof. The bispecific antibody comprises two antigen-binding fragments binding to different epitopes of G protein of rabies virus, and has rabies virus neutralization activity.

Abstract: The present application discloses a novel anti-human IL-17 monoclonal antibody obtained by phage antibody library screening and genetic engineering, or a functional fragment thereof, a polynucleotide encoding the monoclonal antibody or the functional fragment thereof, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or vector, a method for preparing and purifying the antibody, and use of the antibody or the functional fragment thereof.

Abstract: Disclosed are methods for receiving device discovery information and sending device discovery information, and UE. The method for receiving the device discovery information includes that: first UE receives device discovery information sent by second UE, wherein the device discovery information contains at least one piece of the following information: UE identification information and attribute information of the UE; and the first UE performs D2D discovery and/or D2D communication under the condition that the device discovery information is consistent with a preset condition. By the disclosure, the technical problem of difficulty in meeting a requirement on D2D communication diversity caused by containing of only an ID in the device discovery information in the related technology is effectively solved, and the technical effect of improving D2D communication effectiveness and flexibility is achieved.

Abstract: The embodiments of the present document disclose a mobile relay, and a method for enhancing and processing an X2 interface proxy. The method for enhancing an X2 interface proxy comprises: triggering an X2 proxy to relocate from a first node to a second node, or triggering to set up an X2 interface between a third node and the second node; and using the second node as an X2 proxy of the third node and a base station adjacent to the third node.

Abstract: A device-to-device (D2D) discovery method, an eNodeB and a user equipment are disclosed. The method includes: a user equipment acquiring discovery signal resources allocated by an eNodeB (eNB) to the user equipment, wherein the discovery signal resources include time-frequency domain resources used for sending or monitoring a discovery signal; and when the user equipment performs a D2D discovery operation, sending or monitoring the discovery signal according to acquired discovery signal resources to perform D2D discovery.

Abstract: A method and device for mode switching includes: a first base station sending a message including mode switching information to a first User Equipment (UE) to trigger the first UE to perform mode switching according to indication information of a mode in the mode switching information. The problem of poorer service continuity caused by mode switching inflexibility in the related is solved, and the effect of improving overall throughput of a system is further achieved.

Abstract: The present application discloses a novel anti-human IL-17 monoclonal antibody obtained by phage antibody library screening and genetic engineering, or a functional fragment thereof, a polynucleotide encoding the monoclonal antibody or the functional fragment thereof, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or vector, a method for preparing and purifying the antibody, and use of the antibody or the functional fragment thereof.