Abstract: The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.

Abstract: The present invention discloses a bidirectional moving children's rocking frame, comprising a base, a longitudinal frame, a transverse frame, and a bracket, wherein the longitudinal frame and the vertical frame are tangent at a right angle, and the bracket can be disassembled from and installed on the transverse seat. When the longitudinal seat and transverse seat move, the bracket moves along the longitudinal and transverse directions, and simulate the walking steps of the human body, and based on the combined movement of the first driving device and the second driving device, the size or frequency of the stroke can be adjusted to regulate the movement of the bracket.

Abstract: A discrete cosine transform processing device includes an adder, a register, multiple multiply-accumulate operation circuits, an accumulator, an operation control circuit and an output circuit. The adder processes first input data based on a first permutation matrix to generate second input data. The register stores an operation matrix. The operation control circuit configures the multiply-accumulate operation circuits and the accumulator based on a matrix multiplication operation corresponding to a unit dimension, such that the operation matrix and the second input data are multiplied and accumulated by the multiply-accumulate operation circuits and the accumulator to generate a first operation result. The output circuit processes the first operation result based on a second permutation matrix to generate a second operation result, wherein the first permutation matrix, the operation matrix, and the second permutation matrix are derived from decomposition of a discrete cosine transform matrix.

Abstract: A data transmission method includes: displaying, in an acceleration function interface of a first application, a second application to be accelerated, the first application configured to reduce a network latency between the second application and a corresponding target server, and the second application configured to provide a virtual scene; determining a target transmission link based on a network latency of a mobile communication link and a network latency of a wireless communication link in response to a trigger operation on the second application, the target transmission link including at least one of the mobile communication link or the wireless communication link; and performing data transmission with the target server corresponding to the second application based on the target transmission link.

Abstract: Disclosed is a mutant of a wild-type RSV F protein. The binding experiment of a pre-fusion conformation trimer-specific monoclonal antibody AM14 shows that the mutant provided in embodiments can have strong activity of binding to the AM14 monoclonal antibody, while the wild-type RSV F protein before artificial mutation has no activity of binding to the AM14 monoclonal antibody. The accelerated stability test result shows that the activity of binding of the mutant provided in the embodiments when placed in a 37° C. environment for four weeks to the AM14 monoclonal antibody does not change obviously. The animal immune experiment result shows that compared with the wild-type RSV F protein before artificial mutation, the mutant provided in the embodiments can induce production of a neutralizing antibody having a higher titer.

Abstract: This invention presents an enhanced micro-operation target segmentation method utilizing improved Otsu and edge operators, addressing the limitations of conventional techniques in microscopic visual environments. The proposed approach effectively mitigates accuracy constraints caused by image noise and shadow effects from uneven illumination. The methodology comprises three key phases: Applying an optimized bilateral filtering algorithm to perform noise reduction on grayscale images, producing denoised images; Segmenting micro-operation targets using the refined Otsu algorithm on these denoised images to obtain initial segmentation results; Directly applying the final segmentation result when meeting predefined criteria, or conducting iterative segmentation through the enhanced edge operator and Otsu algorithm if necessary.

Abstract: A method for recognition and positioning of micro-operation objects under deflection and occlusion belongs to the technical field of micro-operation object recognition and positioning under microscopic vision. The present invention solves the problem of low positioning accuracy of micro-operation objects by existing methods when the micro-operation objects are deflected or occluded.

Abstract: This disclosure provides an integrated circuit, a chip, and an electronic device. The chip includes D dice, where D is a positive integer greater than or equal to 2, the D dice include a first die and a second die, and the first die and the second die are rotationally symmetrical.

Abstract: The present invention relates to a network automatic train supervision (NATS) system for urban rail transit based on a cloud platform, the NATS system is disposed in a network center cloud platform to collect line ATS data for analysis and provide a network operation management function; and the NATS system has functions of running command, operation index analysis, fully automated mapping, network and line collaborative command, transport organization, and aided decision. Compared with the prior art, the present invention has an advantage that information about full-road networks is displayed for large cities, so that the network center performs overall operation command and dispatching for the cities.

Abstract: A data transmission method includes: displaying, in an acceleration function interface of a first application, a second application to be accelerated, the first application configured to reduce a network latency between the second application and a corresponding target server, and the second application configured to provide a virtual scene; determining a target transmission link based on a network latency of a mobile communication link and a network latency of a wireless communication link in response to a trigger operation on the second application, the target transmission link including at least one of the mobile communication link or the wireless communication link; and performing data transmission with the target server corresponding to the second application based on the target transmission link.

Abstract: A photographing method, including: obtaining a preview stream; detecting a movement speed of a photographed subject according to the preview stream; obtaining a first exposure time by shortening, according to the movement speed, an initial exposure time for preview frames in the preview stream, in response to determining that the movement speed is higher than a preset speed threshold; and capturing a picture based on the first exposure time.

Abstract: The present disclosure provides a pet care machine, including a machine housing, internally provided with an air channel having at least one air channel inlet and at least one air channel outlet; an electric fan, configured to stir air and form an air flow flowing into at least one air channel inlet and out of at least one air channel outlet; a combing member, comprising at least one group of comb teeth, wherein the comb teeth has a received state and an extended state; a motion area, located outside the air channel and communicating at least one air channel outlet with at least one air channel inlet and providing a space for transition of the comb teeth between the extended state and the received state.

Abstract: The present invention discloses an S-RBD trimer protein for a novel coronavirus. The trimer protein is composed of amino acid fragments at positions 319-537 in an RBD domain of an S protein of the novel coronavirus n a trimer form. A body is immunized with a vaccine prepared in the present invention taking the S-RBD trimer protein as an antigen and supplemented by an adjuvant, and then a hic neutralizing antibody for the novel coronavirus may be produced and may be used for treating and/or preventing novel coronavirus (SARS-CoV-2) infection and/or a novel coronavirus disease.

Abstract: The application provides guidance and navigation control (GNC) proteins. In one embodiment, the GNC protein Comprises a T-cell binding moiety and a cancer-targeting moiety, wherein the T-cell binding moiety has a binding specificity to a T-cell receptor comprising CD3, CD28, PDL1, PD1, OX40, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, VISTA, ICOS, BTLA, Light, NKp30, CD28H, CD27, CD226, CD96, CD112R, A2AR, CD160, CD244, CECAM1, CD200R, TNFRSF25 (DR3), or a combination thereof, and wherein the cancer targeting moiety has a binding specificity to a cancer cell receptor.

Abstract: The present invention discloses a control apparatus and method for buoyancy adjustment of shield tunnel segments, wherein the inner end wall of anchor rod accommodating cavity is provided with a first slurry channel extending forward to the outer peripheral wall of anchor rod, the countersunk bolt is provided with a second slurry channel passing through the front and rear end faces of the countersunk bolt, and a locking structure is disposed in the accommodating cavity to lock the countersunk bolt in the accommodating cavity and connect the first slurry channel and second slurry channel. The entire construction process which can be carried out during the construction or operation period greatly reduces construction costs and space.

Abstract: The present disclosure provides a pet care machine, including a machine housing, internally provided with an air channel having at least one air channel inlet and at least one air channel outlet; an electric fan, configured to stir air and form an air flow flowing into at least one air channel inlet and out of at least one air channel outlet; a combing member, comprising at least one group of comb teeth, wherein the comb teeth has a received state and an extended state; a motion area, located outside the air channel and communicating at least one air channel outlet with at least one air channel inlet and providing a space for transition of the comb teeth between the extended state and the received state.

Abstract: An image edge detection method for processing an image including multiple pixels includes performing a convolution operation on the image by a gradient operator in a first direction and a gradient operator in a second direction to obtain a first-direction gradient data and a second-direction gradient data, wherein the first direction is perpendicular to the second direction, performing a gradient statistical calculation within a neighboring area of a target pixel of the image according to the first-direction gradient data and the second-direction gradient data to obtain a gradient statistic, and determining an edge significance corresponding to the target pixel according to the gradient statistic.

Abstract: The present invention provides a recombinant RBD trimer protein capable of simultaneously generating cross neutralization activity for various severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) epidemic strains. The RBD trimer protein is taken as an antigen and supplemented with an adjuvant to immunize an organism, so that a high-titer neutralizing antibody aiming at various SARS-COV-2 epidemic strains can be generated at the same time, and the antibody has a certain broad-spectrum property and can be used for treating and/or preventing SARS-COV-2 infection and/or coronavirus disease 2019.

Abstract: The present disclosure relates to bifunctional compounds comprising targeting moiety that binds SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4 (SMARCA4) or SMARCA2 and SMARCA4, and a degron that binds an E3 ubiquitin ligase. The disclosure further provides compositions and methods for treating diseases or conditions mediated by aberrant activity of SMARCA4 or SMARCA2 and SMARCA4, including diffuse midline glioma harboring a H3K27M mutation.

Abstract: Provided in the present disclosure are IL-15 variants, IL-15/IL-15R?-Fc fusion proteins comprising the IL-15 variants and IL-15/IL-15R? fusion protein comprising the IL-15 variants the methods of producing the same and the uses thereof. The IL-15 variants, fusion proteins, and polypeptide complexes of the disclosure can be used as a potent agent for the treatment of cancers and infectious diseases.