Abstract: Described herein are compounds that are RAF inhibitors and their use in the treatment of disorders such as cancers.

Abstract: Described herein are compounds that are inhibitors of autophagy and their use in the treatment of disorders such as cancers.

Abstract: Provided are a high-strength galvanized steel sheet having excellent distinctness of image after painting and a manufacturing method therefor. The steel sheet includes: by mass %, 0.003 to 0.005% of C, 0.05% or less of Si, 0.4 to 1.0% of Mn, 0.04 to 0.06% of P, 0.01% or less of S, 0.005% or less of N, 0.1% or less of S. Al, 0.05 to 0.08% of Mo, 0.005 to 0.03% of Ti, 0.02 to 0.035% of Nb, 0.06 to 0.1% of Cu, 0.0015% or less of B, and a balance of Fe and inevitable impurities. The alloy microstructure has ferrite in an amount of 95% by area fraction or greater, and the ferrite has a grain average size of 15 ?m or less, with the ultra-fine grain 5 ?m or less having an occupancy ratio to 7 to 10% within 1 mm×1 mm area.

Abstract: Provided are a high-strength hot-dip galvanized steel sheet with excellent formability and a process for producing same. The steel sheet comprises, in mass %: 0.005 to 0.009% of C; 0.05% or less of Si; 0.3 to 0.8% of Mn; 0.06 to 0.09% of P; 0.01% or less of S; 0.005% or less of N; 0.1% or less of Al; 0.05 to 0.08% of Mo; 0.01 to 0.03% of Ti; 0.03 to 0.045% of Nb; 0.06 to 0.1% of Cu; 0.0015% or less of B; and a balance of Fe and inevitable impurities, and 95% or more of ferrite in terms of area fraction. The ferrite has an average grain size of 15 ?m or less, with ultrafine grains of 6 ?m or less occupying 5 to 10% in a 1 mm×1 mm, and the steel sheet has a surface nanohardness value of 1 to 1.5 GPa.

Abstract: A design method for placing and routing a semiconductor device in a computer system includes placing, by the computer system, a plurality of semiconductor devices in a design region, calculating and evaluating, by the computer system, a routing path between the plurality of semiconductor devices, based on a first algorithm, calculating, by the computer system, the routing path between the plurality of semiconductor devices based on a result calculated through the first algorithm and a second algorithm, based on an evaluation result, and comparing the result calculated through the first algorithm with a result calculated through the second algorithm, and verifying the result calculated through the first algorithm, based on a comparison result.

Abstract: Multi-coated nanoparticles including multiple coating layers of chitosan and polyglutamic acid, composition for skin care including the same, and method of manufacturing the same are provided. The nanoparticles have a liposome core layer and coating layers. The core layer includes a bioactive particle and a core hydrogel. Not only is it easy to mass-produce, but also has the effect of steadily releasing bioactive particles for a long period of time due to its high sealing rate and high stability.

Abstract: A chatbot server that provides an instant messaging service using a relay chatbot linked to multiple chatbots includes a receiving unit that receives, from a messenger server, a question message relevant to a service selected from multiple services and service account information corresponding to the selected service; a derivation unit that derives an answer to the question message using the relay chatbot corresponding to the service account information; and a transmission unit that transmits the answer to the messenger server, wherein the relay chatbot relays a user device to the multiple chatbots linked to the relay chatbot to derive the answer through at least one of the multiple chatbots.

Abstract: The present invention relates to compounds of formula (I) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.

Abstract: A preparation process of 5-ethylidene-2-norbornene, including: introducing dicyclopentadiene into a dicyclopentadiene decomposition reactor to thermally decompose the dicyclopentadiene; introducing a product of the above step into a cyclopentadiene purification tower; introducing 1,3-butadiene, a solvent, and cyclopentadiene separated from the top of the cyclopentadiene purification tower into a Diels-Alder reactor to react the same; introducing a product of the immediate above step into a 1,3-butadiene removal tower to recover 1,3-butadiene from the top; introducing a mixture at the bottom of the 1,3-butadiene removal tower into a desolvation tower, and recycling a solvent and unreacted raw materials recovered from the top of the desolvation tower to the dicyclopentadiene decomposition reactor; introducing a mixture at the bottom of the desolvation tower into a 5-vinyl-2-norbornene separation tower to separate 5-vinyl-2-norbornene; and introducing the 5-vinyl-2-norbornene into an isomerization reactor to rea

Abstract: A camera module is provided. The camera module includes a carrier in which a lens barrel is disposed, the carrier configured to move in an optical axis direction, a frame at least partially disposed inside the carrier, a housing which accommodates the carrier, and a buffer member, wherein the frame includes a coupling portion that is exposed to an external area of the carrier, and the buffer member is configured to be coupled to the coupling portion, and a side of the buffer member is disposed to be closer to an internal surface of the housing than a side of the carrier.

Abstract: Provided are a method and apparatus for providing a counseling service. A method of operating a counseling center server interworking with an instant messaging service includes providing a profile of at least one expert account for counseling linked to a channel of a second user to a terminal of a first user, identifying an initiation condition for a counseling ticket for counseling with a first expert account, creating a counseling ticket to be allocated to the first expert account, and transmitting counseling content through a chat room for counseling of the channel in which the first expert account and an account of the first user participate.

Abstract: In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Abstract: A thermodynamic study is performed to identify suitable refrigeration cycles for emerging application to a high-temperature superconductor (HTS) fusion system. According to recent reports on a compact and efficient fusion system, HTS magnets are supposed to operate at about 20 K by forced-flow cooling of helium gas. In addition to the main cryogenic load for the magnets, there are other cooling requirements, including the refrigeration of a thermal shield and current leads. In order to compose a closed refrigeration system without liquid-nitrogen supply or any boil-off loss, modified Brayton cycles are designed to cover the cooling loads with a circulation loop of a coolant for the magnets, the thermal shield, and the current leads. Innovative design is also proposed to integrate the cooling loop with the refrigeration cycle, as helium gas is used as a coolant and a refrigerant.

Abstract: A thermodynamic study is performed to identify suitable refrigeration cycles for emerging application to a high-temperature superconductor (HTS) fusion system. According to recent reports on a compact and efficient fusion system, HTS magnets are supposed to operate at about 20 K by forced-flow cooling of helium gas. In addition to the main cryogenic load for the magnets, there are other cooling requirements, including the refrigeration of a thermal shield and current leads. In order to compose a closed refrigeration system without liquid-nitrogen supply or any boil-off loss, modified Brayton cycles are designed to cover the cooling loads with a circulation loop of a coolant for the magnets, the thermal shield, and the current leads. Innovative design is also proposed to integrate the cooling loop with the refrigeration cycle, as helium gas is used as a coolant and a refrigerant.

Abstract: Proposed is a method of providing internet resource address information using dynamic QR codes. In one embodiment, the method includes the following steps, receiving a first protocol request and extracts a QR code label identification number contained within the first URL from the received first protocol request, using the extracted QR code label identification number as a search key to retrieve redirection link address information from a QR code identification table, extracting redirection code information contained in the second URL upon receiving the forwarded second protocol request, and consulting the redirection link table using the extracted redirection code information as a search key to fetch the internet resource address information.

Abstract: The present invention pertains to a method for producing terephthalic acid in an eco-friendly manner using waste polyester. Specifically, according to an embodiment of the present invention, the method for producing terephthalic acid comprises the steps of: (1) subjecting waste polyester to alcoholysis using a C4 or higher alcohol to produce a liquid composition containing a compound represented by formula 1; and (2) subjecting the liquid composition to hydrolysis, and thus can produce terephthalic acid in an eco-friendly manner, as well as improve processability and reduce process costs.

Abstract: The present invention relates to a method for preparing terephthalic acid, and terephthalic acid prepared therefrom. Specifically, according to one embodiment of the present invention, by including the step of hydrolyzing a compound prepared by depolymerizing a waste polyester using a specific hydrolysis catalyst, terephthalic acid can be prepared in an environmentally friendly manner, and high purity terephthalic acid can be provided.

Abstract: Provided is a method for manufacturing a plated steel sheet. The method includes: performing continuous casting on steel containing, by wt %, 0.003 to 0.009% of C, 0.05% or less of Si, 0.4 to 1.0% of Mn, 0.04 to 0.09% of P, 0.01% or less of S, 0.005% or less of N, 0.1% or less of S·Al, 0.03 to 0.08% of Mo, 0.005 to 0.03% of Ti, 0.02 to 0.045% of Nb, 0.06 to 0.15% of Cu, 0.003% or less of B, and a balance of Fe and unavoidable impurities; reheating a slab obtained by the continuous casting; providing a hot-rolled steel sheet by hot rolling the reheated slab; coiling the hot-rolled steel sheet; providing a cold-rolled steel sheet by cold rolling the hot-rolled steel sheet; annealing the cold-rolled steel sheet; and hot-dip galvanizing the annealed cold-rolled steel sheet by immersing the annealed cold-rolled steel sheet in a zinc-based plating bath.

Abstract: Described herein are compounds that are inhibitors of autophagy and their use in the treatment of disorders such as cancers.

Abstract: A binder for a lithium-sulfur secondary battery cathode, a composition containing the same, and an acrylic binder capable of forming a cross-linked network and a use thereof. The binder contains a polar functional group capable of strongly interacting with sulfur.