Abstract: In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: Leaf nodes of a tree structure, also having a root node and intermediate nodes, communicate with endpoints via access networks and store mappings from permanent virtual IP (VIP) addresses for the endpoints to physical IP (PIP) addresses for the endpoints on the access networks. The root node and intermediate nodes store pointers for the endpoints' leaf nodes and associated access networks. When a connection setup request (CSR) for a destination endpoint is received from a corresponding node, the receiving leaf node passes the CSR up through the tree structure to a lowest common ancestor (LCA) node for the receiving leaf node and one or more destination leaf nodes associated with the destination endpoint. The LCA node uses its pointers to pass the CSR down towards the one or more destination leaf nodes, which use the corresponding VIP-to-PIP mappings to forward the CSR to the destination endpoint.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: Disclosed are micro/nano composite drug delivery compositions for use in diagnosis, prophylaxis, treatment and/or amelioration of one or more symptoms of a mammalian disease, disorder, dysfunction, or abnormal condition. In illustrative embodiments, pharmaceutical formulations comprising these composites are provided that are useful in methods for targeting selected mammalian cells and tissues, particularly human lung tissue, and delivering one or more therapeutic agents, particularly in the treatment of human lung cancers, such as melanoma lung metastases.