Patents by Inventor Yuqiang Wang

Yuqiang Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12187688
    Abstract: A crystal form of tetramethylpyrazine nitrone (TBN), and a preparation method and use thereof is provided. A crystal form A of TBN has characteristic diffraction peaks in the XRPD pattern at 2?°: 10.60±0.2, 11.03±0.2, 15.31±0.2, 15.55±0.2, 17.14±0.2, 17.93±0.2, and 23.81±0.2. The crystal form A has low risk of polymorphism transformation and good stability, which contribute to the stability of the preparations during the production and storage processes, and effectively guarantee the consistency of the content of the crystal form in the preparations. Therefore, the preparations are safe, effective, and controllable in quality. Also, the crystal form A has high biological activity, good druggability, and high bioavailability, fast onset of action.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: January 7, 2025
    Assignee: GUANGZHOU MAGPIE PHARMACEUTICALS CO., LTD.
    Inventors: Wei Liu, Yewei Sun, Yuqiang Wang
  • Publication number: 20240386539
    Abstract: The present application provides a pavement technical condition detection method and device based on a three-dimensional contour. The method includes: acquiring three-dimensional contour data and grayscale data of a pavement on the basis of a line scanning three-dimensional measurement sensor; preprocessing the three-dimensional contour data and the grayscale data, where the preprocessing includes performing three-dimensional modeling according to the three-dimensional contour data to acquire three-dimensional modeling data and correcting the grayscale data; and extracting a key contour of each cross section in the three-dimensional modeling data, and performing pavement technical condition index detection on the pavement according to the three-dimensional modeling data, the key contour, and the corrected grayscale data to acquire a technical condition index of the pavement.
    Type: Application
    Filed: April 7, 2022
    Publication date: November 21, 2024
    Inventors: Min Cao, Hong Lin, Xinlin Wang, Xuan Qu, Yuqiang Wang, Chao Gao, Qi Chen, Xukai Xing
  • Publication number: 20240377459
    Abstract: Provided are method and device for determining grade of energy storage station based on index evaluation system, including for indicator score of at least one of evaluation indicators for each energy storage station, utilizing objective weighting method based on the indicator score of each evaluation indicator of energy storage station to determine objective weight of each evaluation indicator of the energy storage station; utilizing mixed decision-making model based on the indicator score of each evaluation indicator of energy storage station to determine subjective weight of each evaluation indicator of energy storage station; determining comprehensive weight of each evaluation indicator of the energy storage station based on the objective weight and the subjective weight of each evaluation indicator of energy storage station; and utilizing, based on the comprehensive weight of each evaluation indicator of each energy storage station, the TOPSIS method to determine evaluation grade of each energy storage st
    Type: Application
    Filed: January 4, 2024
    Publication date: November 14, 2024
    Applicant: INNER MONGOLIA POWER (GROUP) CO., LTD INNER MONGOLIA POWER RESEARCH INSTITUTE
    Inventors: Zaixin YANG, Baiqing YIN, Minfu A., Yunmin WANG, Yuzhu WU, Jun TAO, Yuqiang WANG, Tao HAN, Feng LIU
  • Publication number: 20240330801
    Abstract: A system and method that includes displaying a graphical depiction of projected demand, with values of the projected demand calculated using a constraint, over a future period of time; displaying, over the graphical depiction, a selectable graphical element at a first position that is associated with a first value of the constraint; and wherein the selectable graphical element is adjustable to change the value of the constraint; receiving an indication that the selectable graphical element has been adjusted to a second position associated with a second value of the constraint; and updating the graphical depiction using updated values for projected demand over the future period of time. Projected demand may be part of transportation-related data, on which basis a recommended management plan for a disruption may be identified, the plan being identified with a network model and including strategic travel leg delays and strategic travel leg cancellations.
    Type: Application
    Filed: October 5, 2023
    Publication date: October 3, 2024
    Inventors: Yuqiang Wang, Shouvik Dutta, Sheng Xu, Duaa Serhan, Sharadha Raghunathan, Denise Gonzales, Steven Olson, Robert Shirley
  • Patent number: 11903923
    Abstract: The present invention provides uses of an andrographolide derivative in preparation of a medicament for preventing and treating inflammatory bowel disease. The andrographolide derivative AL-1 has the mechanisms, for the treatment of ulcerative colitis, of scavenging of free radicals, inhibition of NF-?B signaling pathway activation and COX-2 expression, activation of PPAR-? expression, and thus can prevent the transcription and expression of inflammatory-related genes to improve the conditions of inflammation. AL-1 can be used as a medicine for the treatment of inflammatory bowel disease and can be formulated to various dosage forms with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: February 20, 2024
    Inventors: Yuqiang Wang, Lipeng Xu, Pei Yu, Yewei Sun, Zaijun Zhang, Gaoxiao Zhang, Peng Yi
  • Publication number: 20220371987
    Abstract: The present invention provided a process for manufacture of amantadine nitrate derivatives, and the process comprises using adamantane as the raw material to prepare amantadine nitrate derivatives via the following steps: (1) synthesis of adamantanol; (2) carboxylation of adamantanol; (3) acetylation of adamantanoic acid; (4) reduction; (5) hydrolysis of amido adamantanol and Boc protection of amino group; (6) crystallization of Boc protected amantadinol; (7) nitrate esterification of Boc protected amantadinol; (8) refining of the product of nitrate esterification; (9) Boc deprotection and salt formation; and (10) refining of amantadine nitrate hydrochloride. The amantadine nitrate derivatives have the struction of: wherein, R1 and R2 are each independently hydrogen, straight-chain or branched-chain alkyl, or substituted or unsubstituted aryl or heteroaryl. The process of this invention is efficient, cost effective, environmentally friendly, safe, reliable, and suitable for industrial production.
    Type: Application
    Filed: September 11, 2019
    Publication date: November 24, 2022
    Applicant: QINGDAO HAILAN PHARMACEUTICALS CO., LTD.
    Inventors: Yuqiang WANG, Zheng LIU, Yewei SUN, Zaijun ZHANG, Gaoxiao ZHANG
  • Patent number: 11486393
    Abstract: A scroll compressor of vehicles includes a housing including a first opening to form a receiving space, a compressing mechanism, and an electrical machinery mechanism including a rotor and a stator. The electrical machinery mechanism, located in the receiving space, drives the compressing mechanism to rotates. A lower holder is fixed to an upper holder via the stator. The stator is coupled to a binding post by lead-out wires, and the binding post, away from a bottom wall of the housing, is located between an inner wall of the housing and an outer wall of the stator. The stator and the binding post are directly or indirectly installed to a same component, and a distance between an outlet of the lead-out wires and the binding post is constant during the assembling process of the binding post and the lead-out wires.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: November 1, 2022
    Assignee: SHANGHAI HIGHLY NEW ENERGY TECHNOLOGY CO., LTD.
    Inventors: Xuefeng Song, Yuqiang Wang
  • Publication number: 20220313269
    Abstract: A distal portion (16) of an elongated body (12) is configured to mate with a distal portion (20) of an interface member (18) mechanically connected to an embolization device (22). The embolization device (22) is additionally attached to the elongated body (12). The elongated body distal portion (16) and the interface member proximal portion (19) may collectively define a protrusion and a recess configured to receive the protrusion to provide the mating. The elongated body (12), interface member (18), and embolization device (22) may be configured for delivery to a vasculature target site, and manipulation of the deployed embolization device (22) may be facilitated by the mating between the elongated body (12) and the interface member (18).
    Type: Application
    Filed: July 19, 2019
    Publication date: October 6, 2022
    Inventors: Yihan Wang, Yuqiang Wang, Yunguo Qin, Junmin Guo, Shengfeng Shi
  • Publication number: 20220202812
    Abstract: The present invention relates to the use of ligustrazine nitrone derivatives and pharmaceutical composition thereof for the treatment and prevention of diseases of diabetic complications, which include renal anemia. The ligustrazine nitrone derivatives have the structure of the general formula (I). Experimental results indicated that the ligustrazine nitrone derivatives can significantly increase the levels of serum iron and erythropoietin in STZ induced SD rats and spontaneously hypertensive rats, and can be used for treating and preventing renal anemia caused by decrease in renal EPO production and/or concomitant iron deficiency. Therefore, the ligustrazine nitrone derivatives can be made into various dosage forms with a drug carrier. The derivatives can be prepared into various dose forms together with drug carriers.
    Type: Application
    Filed: November 3, 2021
    Publication date: June 30, 2022
    Applicant: QINGDAO HAILAN PHARMACEUTICALS CO., LTD.
    Inventors: Yuqiang Wang, Yewei Sun, Lipeng Xu, Mei Jing, Zaijun Zhang, Gaoxiao Zhang, Pei Yu, Peng Yi
  • Patent number: 11359628
    Abstract: A compressor comprises a housing including a first opening to form a receiving space and a retaining wall, wherein the receiving space is divided, by the retaining wall, a low-pressure chamber and a controller chamber. A compressing mechanism further comprises a fixed scroll plate including a low-pressure side of scroll wraps and a high-pressure side, opposite to the scroll wraps; an orbiting scroll plate, located in the receiving space, including a side, facing the scroll wraps of the fixed scroll plate, of scroll wraps and a compression chamber is formed by the scroll wraps of the fixed scroll plate and the scroll wraps of the orbiting scroll plate; an electrical machinery mechanism, located in the low-pressure chamber, including a rotor and a stator, wherein the electrical machinery mechanism drives the compressing mechanism to rotates to compress refrigerant in the compression chamber.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: June 14, 2022
    Assignee: SHANGHAI HIGHLY NEW ENERGY TECHNOLOGY CO., LTD.
    Inventors: Xuefeng Song, Yuqiang Wang, Yingtao Mou
  • Publication number: 20220168299
    Abstract: The present invention discloses a pharmaceutical composition comprising TBN, or a salt or a hydrate thereof, and a preparation method therefor. The pharmaceutical composition comprises (1) a tablet core comprising the active ingredient TBN or a pharmaceutically acceptable salt or hydrate thereof and an alkalizing agent; and (2) an enteric layer outside the tablet core, comprising an opaquer and a coating material. The pharmaceutical composition has the enteric layer with good film-forming ability, which improves the bioavailability of TBN in the body; and is useful in the treatment of diseases caused by overproduction of free radicals/thrombosis in clinic.
    Type: Application
    Filed: July 31, 2019
    Publication date: June 2, 2022
    Applicant: GUANGZHOU MAGPIE PHARMACEUTICALS CO., LTD.
    Inventors: Wei LIU, Yewei SUN, Yuqiang WANG
  • Publication number: 20220153707
    Abstract: A crystal form of tetramethylpyrazine nitrone (TBN), and a preparation method and use thereof is provided. A crystal form A of TBN has characteristic diffraction peaks in the XRPD pattern at 2?°: 10.60±0.2, 11.03±0.2, 15.31±0.2, 15.55±0.2, 17.14±0.2, 17.93±0.2, and 23.81±0.2. The crystal form A has low risk of polymorphism transformation and good stability, which contribute to the stability of the preparations during the production and storage processes, and effectively guarantee the consistency of the content of the crystal form in the preparations. Therefore, the preparations are safe, effective, and controllable in quality. Also, the crystal form A has high biological activity, good druggability, and high bioavailability, fast onset of action.
    Type: Application
    Filed: July 31, 2019
    Publication date: May 19, 2022
    Applicant: GUANGZHOU MAGPIE PHARMACEUTICALS CO., LTD.
    Inventors: Wei LIU, Yewei SUN, Yuqiang WANG
  • Patent number: 11197855
    Abstract: A use of of ligustrazine nitrone derivatives and a pharmaceutical composition thereof in the preparation of medicine for preventing and treating diabetic complication diseases. The ligustrazine nitrone derivatives can be prepared into various dose forms together with drug carriers.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: December 14, 2021
    Inventors: Yuqiang Wang, Yewei Sun, Lipeng Xu, Mei Jing, Zaijun Zhang, Gaoxiao Zhang, Pei Yu, Peng Yi
  • Patent number: 11181356
    Abstract: A three-coordinate measuring system includes a three-coordinate measuring apparatus, and a type collector for a product to be measured; the apparatus is provided with a probe, and a control component which controls motion of the probe through a measuring program preset according to product type of the product to be measured, the control component is electrically connected to the probe; the type collector includes an optical collecting head capable of scanning a graphic identifier, the optical collecting head is electrically connected to the control component; the control component acquires the product type of the product to be measured according to the graphic identifier scanned by the optical collecting head, and call a corresponding measuring program to control the motion of the probe in order to measure the product to be measured and acquire measuring data, a method for three-coordinate measuring is also provided.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: November 23, 2021
    Assignee: CITIC Dicastal CO., LTD.
    Inventors: Zuo Xu, Liang Huang, Yuqiang Wang, Honglei Liu, Bao Zhang, Jinqi Lyu, Qingbo Kong
  • Patent number: 11161800
    Abstract: The present invention relates to amantadine nitrate compounds having neural protective effect, and preparation method and medical use thereof. The compounds have the structure of the general formula (II). The compounds have multifunctional mechanisms, including inhibiting NMDA receptors, releasing NO, inhibiting calcium influxes, and having protective effects on cells particularly neurocytes. The compounds can be used in the preparation of medicaments having a cellular protective effect, for prevention or treatment of the diseases related to such as NMDA receptors and elevation of calcium anions in cells, including the diseases related to neurodegeneration such as Alzheimer's disease, Parkinson's disease, cerebral paralysis and glaucoma, and the diseases related to cardio-cerebral-vascular system such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as respiratory tract infections caused by influenza virus.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: November 2, 2021
    Inventors: Yuqiang Wang, Zheng Liu, Pei Yu, Yewei Sun, Zaijun Zhang, Gaoxiao Zhang, Luchen Shan, Peng Yi, James Larrick
  • Patent number: 10703730
    Abstract: The present invention relates to trifluoroacetyl hydrazide compounds and medical uses thereof. The compounds have a structure of the following formula: The compounds showed multifunctional mechanisms, including inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, clearance of free radicals, and promotion of nerve differentiation, and has a better protective effect on cells especially nerve cells. The compound can be used to prepare prophylactic or therapeutic medicaments with cytoprotective effects, for the prevention or treatment of diseases related to glutamate receptor activation, MEF2 disorders or excessive free radicals generation. The diseases include, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson and stroke, and the free radicals related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: July 7, 2020
    Inventors: Yuqiang Wang, Haiyun Chen, Zaijun Zhang, Gaoxiao Zhang, Pei Yu, Yewei Sun, Luchen Shan, Liang Tao
  • Patent number: 10703729
    Abstract: The present invention relates to a pyrazine derivative, and preparation method and medical use thereof. The pyrazine derivative can remove free radicals and suppress calcium overload and has cytoprotective effects, and can be used for the prevention and treatment of cardiovascular and cerebrovascular diseases, neurodegenerative diseases and other related diseases.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: July 7, 2020
    Inventors: Yuqiang Wang, Pei Yu, Yewei Sun, Luchen Shan, Gaoxiao Zhang, Zaijun Zhang, Peng Yi
  • Publication number: 20200155548
    Abstract: A use of of ligustrazine nitrone derivatives and a pharmaceutical composition thereof in the preparation of medicine for preventing and treating diabetic complication diseases. The ligustrazine nitrone derivatives can be prepared into various dose forms together with drug carriers.
    Type: Application
    Filed: May 25, 2018
    Publication date: May 21, 2020
    Applicant: QINGDAO HAILAN PHARMACEUTICALS CO., LTD.
    Inventors: Yuqiang Wang, Yewei Sun, Lipeng Xu, Mei Jing, Zaijun Zhang, Gaoxiao Zhang, Pei Yu, Peng Yi
  • Publication number: 20200149858
    Abstract: A three-coordinate measuring system includes a three-coordinate measuring apparatus, and a type collector for a product to be measured; the apparatus is provided with a probe, and a control component which controls motion of the probe through a measuring program preset according to product type of the product to be measured, the control component is electrically connected to the probe; the type collector includes an optical collecting head capable of scanning a graphic identifier, the optical collecting head is electrically connected to the control component; the control component acquires the product type of the product to be measured according to the graphic identifier scanned by the optical collecting head, and call a corresponding measuring program to control the motion of the probe in order to measure the product to be measured and acquire measuring data, a method for three-coordinate measuring is also provided.
    Type: Application
    Filed: June 27, 2019
    Publication date: May 14, 2020
    Applicant: CITIC Dicastal CO., LTD.
    Inventors: Liang HUANG, Yuqiang WANG, Honglei LIU, Bao ZHANG, Jinqi LYU, Qingbo KONG
  • Publication number: 20200132072
    Abstract: A compressor comprises a housing including a first opening to form a receiving space and a retaining wall, wherein the receiving space is divided, by the retaining wall, a low-pressure chamber and a controller chamber. A compressing mechanism further comprises a fixed scroll plate including a low-pressure side of scroll wraps and a high-pressure side, opposite to the scroll wraps; an orbiting scroll plate, located in the receiving space, including a side, facing the scroll wraps of the fixed scroll plate, of scroll wraps and a compression chamber is formed by the scroll wraps of the fixed scroll plate and the scroll wraps of the orbiting scroll plate; an electrical machinery mechanism, located in the low-pressure chamber, including a rotor and a stator, wherein the electrical machinery mechanism drives the compressing mechanism to rotates to compress refrigerant in the compression chamber.
    Type: Application
    Filed: March 7, 2018
    Publication date: April 30, 2020
    Applicant: SHANGHAI HIGHLY NEW ENERGY TECHNOLOGY CO., LTD.
    Inventors: Xuefeng SONG, Yuqiang WANG, Yingtao MOU